Contrasting Epidemiology of Acute Rheumatic Fever and Acute Glomerulonephritis

1970 ◽  
Vol 283 (11) ◽  
pp. 561-565 ◽  
Author(s):  
Alan L. Bisno ◽  
Iris A. Pearce ◽  
Hershel P Wall ◽  
Max D. Moody ◽  
Gene H. Stollerman
2021 ◽  
Vol 8 (39) ◽  
pp. 3441-3447
Author(s):  
Thushara Ushakumari Bhuvanendran ◽  
Beena V.G.

BACKGROUND Pharyngotonsillitis is defined as a spectrum of conditions ranging from inflammation primarily confined to the tonsils to pharyngitis implying generalized inflammation of the whole of pharynx. Children are more prone to get several episodes of pharyngotonsillitis per year during their school years. Pharyngitis caused by Streptococcus pyogenes can cause two non-suppurative complications, acute rheumatic fever and acute glomerulonephritis which is responsible for significant morbidity and mortality. The present study was conducted to identify the prevalence of bacterial pathogens causing pharyngotonsillitis and to study their antibiotic sensitivity pattern that would indicate the optimum line of treatment. METHOD A total of 200 children at the age group of 2 - 12 years who had clinical features of pharyngotonsillitis according to the inclusion criteria were recruited for this study over a period of one year. With the help of a disposable wooden spatula, pus from the pharyngo tonsillar region was collected and processed. Predominant isolates obtained were identified and antibiotic sensitivity was done. RESULTS Bacteria was isolated from 70 samples. Pharyngotonsillitis was found most prevalent at the age group of 8 – 10 years. Intake of cold food stuffs and passive smoking at home was found to have statistically significant association as risk factor for pharyngotonsillitis. Staphylococcus aureus was the most common organism isolated followed by Streptococcus pyogenes. The other organisms isolated were group G and C streptococci, Streptococcus pneumoniae, Pseudomonas aeruginosa and Klebsiella pneumonia sub species (spp) aerogenes. CONCLUSIONS Staphylococcus aureus was the most common organism isolated, followed by Streptococcus pyogenes. All the isolates of beta haemolytic streptococci were found to be sensitive to penicillin. There was increased incidence of resistance to macrolides among the gram-positive isolates except Streptococcus pneumoniae and it may be due to the wide spread use of macrolides injudiciously. All the bacterial pharyngotonsillitis cases were cured with the antibiotic given according to the sensitivity except one case. KEYWORDS Pharyngotonsillitis, Acute Rheumatic Fever, Acute Glomerulonephritis, Bacterial Pathogens, Antibiogram


1972 ◽  
Vol 125 (6) ◽  
pp. 619-625 ◽  
Author(s):  
E. V. Potter ◽  
M. Svartman ◽  
E. G. Burt ◽  
J. F. Finklea ◽  
T. Poon-King ◽  
...  

PEDIATRICS ◽  
1962 ◽  
Vol 29 (4) ◽  
pp. 527-538
Author(s):  
Elia M. Ayoub ◽  
Lewis W. Wannamaker

Antibody titers for two recently described streptococcal antigens, desoxyribonuclease B (DNase B) and diphosphopyridine nucleotidase (DPNase) have been compared with antistreptolysin O (ASO) titers in patients with acute rheumatic fever, in patients with acute nephritis, and in normal controls. Like the ASO, elevated titers for the two new antibodies are commonly found in patients with complications of streptococcal infections. The titers for anti-DPNase tend to be higher in acute nephritis than in acute rheumatic fever. These two new anti-body tests are particularly useful in providing evidence of a preceding streptococcal infection in those patients with manifestations of acute rheumatic fever or acute nephritis who fail to show an elevated ASO titer.


1995 ◽  
Vol 37 (3) ◽  
pp. 381-383 ◽  
Author(s):  
HIROYUKI IMANAKA ◽  
SUGURU ETO ◽  
SYUJI TAKEI ◽  
MASAO YOSHINAGA ◽  
MASASHI HOKONOHARA ◽  
...  

1978 ◽  
Vol 92 (2) ◽  
pp. 325-333 ◽  
Author(s):  
Elizabeth V. Potter ◽  
Mauri Svartman ◽  
Isahak Mohammed ◽  
Reginald Cox ◽  
Theo Poon-King ◽  
...  

1986 ◽  
Vol 32 (5) ◽  
pp. 225-229 ◽  
Author(s):  
J. McCusker ◽  
A. Al-Omair ◽  
A.M. Al-Swailem ◽  
T. Sweeny

PEDIATRICS ◽  
1964 ◽  
Vol 33 (3) ◽  
pp. 334-340
Author(s):  
M. Mirowski ◽  
Beryl J. Rosenstein ◽  
Milton Markowitz

1. Atrio-ventricular conduction was studied in 50 normal children, 25 children with acute febrile illnesses, 50 patients with an initial episode of active rheumatic carditis, 46 patients with acute rheumatic fever without clinical evidence of carditis, and 39 children with acute post-streptococcal glomerulonephritis. 2. Quantitative measurements of A-V conduction were obtained by calculating the P-R index, the ratio between the recorded P-R interval (numerator) and the upper limit of normal for the age and heart rate as given in standard tables (denominator). 3. The mean P-R indices were similar in patients with acute rheumatic fever without clinical evidence of myocardial involvement and in children with overt carditis, and were significantly higher than in normal children, children with acute febrile illnesses of patients with acute glomerulonephritis. 4. The frequency with which high P-R indices were found in patients with acute rheumatic fever suggests that disturbances in A-V conduction are even more common than has been previously recognized from conventional P-R interval determinations. 5. The data suggest also that A-V conduction abnormalities in acute rheumatic fever occur independent of other signs of myocardial involvement and are not related to the ultimate prognosis.


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