A COMPARISON OF ATRIO-VENTRICULAR CONDUCTION IN NORMAL CHILDREN AND IN PATIENTS WITH RHEUMATIC FEVER, GLOMERULONEPHRITIS, AND ACUTE FEBRILE ILLNESSES

PEDIATRICS ◽  
1964 ◽  
Vol 33 (3) ◽  
pp. 334-340
Author(s):  
M. Mirowski ◽  
Beryl J. Rosenstein ◽  
Milton Markowitz
Keyword(s):  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Clinical Evidence ◽  
Acute Glomerulonephritis ◽  
Normal Children ◽  
Quantitative Measurements ◽  
Myocardial Involvement ◽  
The Mean ◽  
Post Streptococcal Glomerulonephritis ◽  
Ventricular Conduction

1. Atrio-ventricular conduction was studied in 50 normal children, 25 children with acute febrile illnesses, 50 patients with an initial episode of active rheumatic carditis, 46 patients with acute rheumatic fever without clinical evidence of carditis, and 39 children with acute post-streptococcal glomerulonephritis. 2. Quantitative measurements of A-V conduction were obtained by calculating the P-R index, the ratio between the recorded P-R interval (numerator) and the upper limit of normal for the age and heart rate as given in standard tables (denominator). 3. The mean P-R indices were similar in patients with acute rheumatic fever without clinical evidence of myocardial involvement and in children with overt carditis, and were significantly higher than in normal children, children with acute febrile illnesses of patients with acute glomerulonephritis. 4. The frequency with which high P-R indices were found in patients with acute rheumatic fever suggests that disturbances in A-V conduction are even more common than has been previously recognized from conventional P-R interval determinations. 5. The data suggest also that A-V conduction abnormalities in acute rheumatic fever occur independent of other signs of myocardial involvement and are not related to the ultimate prognosis.

QT dispersion in acute rheumatic fever

2006 ◽  
Vol 16 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Tugcin Bora Polat ◽  
Yalim Yalcin ◽  
Celal Akdeniz ◽  
Cenap Zeybek ◽  
Abdullah Erdem ◽  
...  
Keyword(s):  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Qt Dispersion ◽  
Control Group ◽  
Healthy Children ◽  
Rheumatic Carditis ◽  
Normal Children ◽  
A Value ◽  
The Mean

Background:Disturbances of conduction are well known in the setting of acute rheumatic fever. The aim of this study is to investigate the QT dispersion as seen in the surface electrocardiogram of children with acute rheumatic fever.Methods:QT dispersion was quantitatively evaluated in 88 children with acute rheumatic fever. Patients were divided into two groups based on the absence or presence of carditis. As a control group, we studied 36 healthy children free of any disease, and matched for age with both groups. Repeat echocardiographic examinations were routinely scheduled in all patients at 3 months after the initial attack to study the evolution of valvar lesions.Results:The mean QT dispersion was significantly higher in children with rheumatic carditis. But there was no statistical difference between children without carditis and normal children. Among the children with carditis, the mean dispersion was higher in those with significant valvar regurgitation. Dispersion of greater than 55 milliseconds had a sensitivity of 85%, and specificity of 70%, in predicting rheumatic carditis, while a value of 65 milliseconds or greater had sensitivity of 81% specificity of 85% in predicting severe valvar lesions in acute rheumatic carditis. At follow-up examination, a clear reduction on the QT dispersion was the main finding, reflecting an electrophysiological improvement.Conclusions:These observations suggest that QT dispersion is increased in association with cardiac involvement in children with acute rheumatic fever.

Bacterial Aetiology of Pharyngotonsillitis in Paediatric Age Group in a Tertiary Care Hospital in Kerala

2021 ◽  
Vol 8 (39) ◽  
pp. 3441-3447
Author(s):  
Thushara Ushakumari Bhuvanendran ◽  
Beena V.G.
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Rheumatic Fever ◽  
Streptococcus Pyogenes ◽  
Acute Rheumatic Fever ◽  
Bacterial Pathogens ◽  
Antibiotic Sensitivity ◽  
Acute Glomerulonephritis ◽  
Age Group ◽  
Common Organism

BACKGROUND Pharyngotonsillitis is defined as a spectrum of conditions ranging from inflammation primarily confined to the tonsils to pharyngitis implying generalized inflammation of the whole of pharynx. Children are more prone to get several episodes of pharyngotonsillitis per year during their school years. Pharyngitis caused by Streptococcus pyogenes can cause two non-suppurative complications, acute rheumatic fever and acute glomerulonephritis which is responsible for significant morbidity and mortality. The present study was conducted to identify the prevalence of bacterial pathogens causing pharyngotonsillitis and to study their antibiotic sensitivity pattern that would indicate the optimum line of treatment. METHOD A total of 200 children at the age group of 2 - 12 years who had clinical features of pharyngotonsillitis according to the inclusion criteria were recruited for this study over a period of one year. With the help of a disposable wooden spatula, pus from the pharyngo tonsillar region was collected and processed. Predominant isolates obtained were identified and antibiotic sensitivity was done. RESULTS Bacteria was isolated from 70 samples. Pharyngotonsillitis was found most prevalent at the age group of 8 – 10 years. Intake of cold food stuffs and passive smoking at home was found to have statistically significant association as risk factor for pharyngotonsillitis. Staphylococcus aureus was the most common organism isolated followed by Streptococcus pyogenes. The other organisms isolated were group G and C streptococci, Streptococcus pneumoniae, Pseudomonas aeruginosa and Klebsiella pneumonia sub species (spp) aerogenes. CONCLUSIONS Staphylococcus aureus was the most common organism isolated, followed by Streptococcus pyogenes. All the isolates of beta haemolytic streptococci were found to be sensitive to penicillin. There was increased incidence of resistance to macrolides among the gram-positive isolates except Streptococcus pneumoniae and it may be due to the wide spread use of macrolides injudiciously. All the bacterial pharyngotonsillitis cases were cured with the antibiotic given according to the sensitivity except one case. KEYWORDS Pharyngotonsillitis, Acute Rheumatic Fever, Acute Glomerulonephritis, Bacterial Pathogens, Antibiogram

scholarly journals Group G streptococci in healthy school-children and in patients with glomerulonephritis in Trinidad

1985 ◽  
Vol 94 (1) ◽  
pp. 61-68 ◽  
Author(s):  
H. F. M. Reid ◽  
D. C. J. Bassett ◽  
T. Poon-King ◽  
J. B. Zabriskie ◽  
S. E. Read
Keyword(s):  
Rheumatic Fever ◽  
Hospital Admissions ◽  
Skin Lesions ◽  
High Rate ◽  
Colonization Rate ◽  
Acute Glomerulonephritis ◽  
Healthy Children ◽  
Group G Streptococci ◽  
Post Streptococcal Glomerulonephritis ◽  
School Surveys

SUMMARYThe group G streptococcus has generally not been considered a prominent pathogen. In a 1982 study of the colonization rate by β-haemoly tic streptococci in apparently healthy children, age 5–11 years, 25 of 69 isolates belonged to group G. This surprisingly high rate of group G colonization (14·3%) led to a retrospective study of school surveys in 1967 which showed that the colonization rate with this organism was 2·3% (range 1·3–3·5%). A review of bacitracin-sensitive streptococcal isolates from hospital admissions of patients with acute glomerulonephritis (AGN), rheumatic fever, and their siblings, between January 1967 and July 1980, was conducted. Of 1063 bacitracin-sensitive isolates, 63 were group G, and 52 of these were isolated from AGN patients and their siblings, i.e. 7 from skin lesions of AGN patients, 40 from the throats of siblings and only 5 from the skins of the siblings. The other 11 group G isolates were from rheumatic-fever patients and their siblings. Thus, the group G colonization rate fluctuates in the population. The isolation of only group G streptococci from skin lesions of patients with AGN suggests a possible association between group G streptococcal pyoderma and acute post-streptococcal glomerulonephritis.

Acute rheumatic fever in the paediatric population: a descriptive study in the Malaysian state of Sabah

2021 ◽  
pp. 1-5
Author(s):  
Farul R Patel ◽  
Jason Wy Tan ◽  
Siva Rao
Keyword(s):  
Heart Disease ◽  
Rheumatic Fever ◽  
Rheumatic Heart Disease ◽  
Acute Rheumatic Fever ◽  
Paediatric Population ◽  
Disease Registry ◽  
Male Patients ◽  
The Mean ◽  
Time Of Presentation ◽  
Rheumatic Heart

Abstract Introduction: Rheumatic heart disease is among the leading causes of acquired valvular heart disease in the developing world. However, there is no data available for rheumatic heart disease in the paediatric population of Sabah. This study collected data for acute rheumatic fever admissions among the paediatric population in Sabah over a period of 3 years. Methods: This is a retrospective cohort study. All records for admissions to paediatric wards in Sabah for acute rheumatic fever from January 2016 to December 2018 were collected. The patient records were then traced and required information were collected. Results: A total of 52 cases of acute rheumatic fever were admitted. It was observed that the incidence of acute rheumatic fever was 74.4 per 100,000 paediatric admissions. Patients from the West Coast Division made up most of the admissions (n = 24, 46.2%). Male patients (n = 35, 67.3%) of the indigenous Kadazan-Dusun ethnicity (n = 21, 40.4%) were most commonly encountered. The mean age at time of presentation was 9.58 years. Most cases admitted (n = 38, 73.1%) were categorised as Priority 1 (severe rheumatic heart disease). Conclusion: Most patients who were admitted had symptoms of heart failure and were diagnosed with severe rheumatic heart disease. Although this disease is preventable, the incidence in Sabah remains high. This study was limited as we only looked at patients who were admitted and we foresee the real incidence to be higher. Hence, there is an urgent need for a rheumatic heart disease registry in Malaysia to gather more data for prevention and early intervention.

Contrasting Epidemiology of Acute Rheumatic Fever and Acute Glomerulonephritis

1970 ◽  
Vol 283 (11) ◽  
pp. 561-565 ◽  
Author(s):  
Alan L. Bisno ◽  
Iris A. Pearce ◽  
Hershel P Wall ◽  
Max D. Moody ◽  
Gene H. Stollerman
Keyword(s):  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Acute Glomerulonephritis

Relationship of Acute Rheumatic Fever to Acute Glomerulonephritis in Trinidad

1972 ◽  
Vol 125 (6) ◽  
pp. 619-625 ◽  
Author(s):  
E. V. Potter ◽  
M. Svartman ◽  
E. G. Burt ◽  
J. F. Finklea ◽  
T. Poon-King ◽  
...  
Keyword(s):  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Acute Glomerulonephritis ◽  
Relationship Of

EVALUATION OF THE STREPTOCOCCAL DESOXYRIBO-NUCLEASE B AND DIPHOSPHOPYRIDINE NUCLEOTIDASE ANTIBODY TESTS IN ACUTE RHEUMATIC FEVER AND ACUTE GLOMERULONEPHRITIS

PEDIATRICS ◽  
1962 ◽  
Vol 29 (4) ◽  
pp. 527-538
Author(s):  
Elia M. Ayoub ◽  
Lewis W. Wannamaker
Keyword(s):  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Streptococcal Infection ◽  
Acute Glomerulonephritis ◽  
Streptococcal Infections ◽  
Antibody Titers ◽  
Streptococcal Antigens ◽  
Anti Body ◽  
Antibody Tests ◽  
Normal Controls

Antibody titers for two recently described streptococcal antigens, desoxyribonuclease B (DNase B) and diphosphopyridine nucleotidase (DPNase) have been compared with antistreptolysin O (ASO) titers in patients with acute rheumatic fever, in patients with acute nephritis, and in normal controls. Like the ASO, elevated titers for the two new antibodies are commonly found in patients with complications of streptococcal infections. The titers for anti-DPNase tend to be higher in acute nephritis than in acute rheumatic fever. These two new anti-body tests are particularly useful in providing evidence of a preceding streptococcal infection in those patients with manifestations of acute rheumatic fever or acute nephritis who fail to show an elevated ASO titer.

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