In order to break through the limitation of the width of river, depth of water, channel and etc., it is an optimal choice to construct a long-span suspension bridge. In a suspension bridge, the main cable is the major bearing member; and the use of super high strength cable wire can lighten the dead weight and obtain an economical design. 1960 Mpa cable wire is adopted by an under-construction suspension bridge, namely Ni-Zhou Channel Bridge, for the first time in China. In this paper, taking the Ni-Zhou Channel Bridge as a case-study, comparative analyses on dynamic characteristic and seismic response of long-span suspension bridge with 1960 Mpa cable wire are performed. Firstly, dynamic calculating model for Ni-Zhou Channel Bridge is built and its dynamic characteristics are studied; then by using response spectrum and time history analysis method, seismic response of Ni-Zhou Channel Bridge is investigated on the basis of design response spectrum and artificial seismic ground motions; finally, the energy dissipation performances of a seismic protection devices (viscous damper) are also discussed. The results show that long-span suspension bridge with 1960 Mpa cable wire has a longer natural vibration period; the use of viscous damper can effectively reduce the peak value of bending moment in stiffening girder. This paper can provide references for the project’s construction.