This paper deals with an isolation design methods of buried segment pipeline for large ground displacement in earthquake. The buried pipeline is always damaged due to the strong shaking and earthquake-induced large or permant ground displacement and deformation (PGD), including liquefaction, rock and soil slope failure, fault and fissure. Based on the seismic response analysis for buried segment pipeline, the isolation mechanism and an equipment for resisting ground displacement trigged by liquefaction and fault is presented in this paper. Some related parameters to isolation system like stiffness and damp of isolator, soil types and its displacement, depth of pipeline, are discussed for developing a reliable isolation system fitting the buried segment pipeline.