Asymptomatic Hypoxemia as a Characteristic Symptom of Coronavirus Disease: A Narrative Review of Its Pathophysiology

Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a pandemic and caused a huge burden to healthcare systems worldwide. One of the characteristic symptoms of COVID-19 is asymptomatic hypoxemia, also called happy hypoxia, silent hypoxemia, or asymptomatic hypoxemia. Patients with asymptomatic hypoxemia often have no subjective symptoms, such as dyspnea, even though hypoxemia is judged by objective tests, such as blood gas analysis and pulse oximetry. Asymptomatic hypoxemia can lead to acute respiratory distress syndrome, and the delay in making a diagnosis and providing initial treatment can have fatal outcomes, especially during the COVID-19 pandemic. Thus far, not many studies have covered asymptomatic hypoxemia. We present a review on the human response to hypoxemia, focusing on the respiratory response to hypoxemia rather than the pathophysiology of lung injury arising from SARS-CoV-2 infection. We have also discussed whether asymptomatic hypoxemia is specific to SARS-CoV-2 infection or a common phenomenon in lung-targeted viral infections.

Floral Aromatics of Ptelea: Chemical Identification and Human Response

Many members of the citrus family (Rutaceae) are valued for the aromatic compounds emitted by their flowers. Ptelea species are unusually cold-hardy members of the Rutaceae, but conflicting descriptions of the fragrance of their unisexual flowers may discourage the use of these trees. We analyzed floral volatiles and human response to these chemicals to test the hypothesis that the fragrance of staminate and pistillate flowers of these species differs. Gas chromatography and mass spectrometry showed that most volatile chemicals emitted by flowers of Ptelea trifoliata and Ptelea crenulata are monoterpenes, sesquiterpenes, and esters. Most volatiles were emitted from flowers of both sexes, but ethyl benzoate and estragole were emitted only from pistillate flowers. When concentrations of aromatics differed between sexes, they were higher for pistillate flowers, except for cis-3-hexenyl butanoate and an unidentified terpene. For P. crenulata and P. trifoliata, respectively, 81% and 77% of survey responses were from volunteers who liked the fragrance. Panelists most frequently described the scent of flowers of P. crenulata of both sexes with the words citrus, lime, and sweet. Panelists distinguished between pistillate and staminate flowers of P. trifoliata, describing the odor of pistillate flowers most frequently with the words damp-earthy, spicy, and sweet; staminate flowers were perceived as light, fresh, grassy, and pleasant. This work represents the first analysis of floral volatiles of P. crenulata and resolves conflicting prior reports regarding the floral fragrance of P. trifoliata. We conclude that differences among people rather than the sex of flowers account for conflicting prior reports of floral fragrance. The scents of flowers of P. crenulata and P. trifoliata appeal to most people and are horticultural assets of these trees.

Káromkodásból katedrálist: lelkigondozás és spiritualitás összefüggései Jób könyvében

A Cathedral Built on Swearing? Interrelations between Counselling and Spirituality in the Book of Job. Given its enormous exegetical potential, pastoral care could clearly lay hold more of the Book of Job’s kerygmatic rather than its psychological certainties. In addition to the Book of Job being often read as a case study about the suffering person’s sense of justice and quest for meaning, Job’s experience has a spiritual overtone as well: he is faced with the question of the true nature of God and the need to find an adequate human response to it. Also, the Book is indicative of how people respond to the suffering and what witness and support they offer. In this paper, I evaluate the counselling strategies in the Book of Job identified by Manfred Oeming. I pay special attention to Job’s wife, and I argue that she should not be considered a proper counsellor, as she herself is stricken by the same tragic events as is Job. Instead, she is a fellow sufferer, although acknowledged as such only by extracanonical literature. What is more, she may be identified as the partner or the first and foremost caregiver of the sufferer whose challenges and difficulties remain unidentified, unspoken of, and unaddressed most of the time. As for the spiritual issues aroused by suffering, I suggest that both counsellor and counsellee must reach spiritual maturity to be able to understand and accept their experience of suffering as a genuine experience of God, and so, given time, this may make space for God’s theophany and healing presence. Keywords: Book of Job, suffering, spirituality, pastoral care, counselling, fellow sufferer, caregiver

Bee Positive: Design for Awareness

<p>This thesis aims to create a museum dedicated to awareness, research, and education, in an attempt to preserve the declining bee population. It focuses on the Native Bees of New Zealand in conjunction with introduced bees. The architectural design intention for the bee museum aims to encapsulate the life and biology of the bee through an informative experience of current issues, by delving into the current world in which bees exist, as well as an ephemeral architectural expression based on organic elements occurring in nature. The aim is to adhere to an emotional as well as a cognitive human response for the sake of forming an empathetic connection between the occupier and the architectural subject. This has the potential to aid the bee population through a captivating and informative design, raising further awareness as to what the issue is and how it can potentially be resolved through public initiative. The promotion of bee conservation in New Zealand may have a prospective ecological impact on a national scale and may subsequently have the potential to work as an example for other countries in their approach to this global concern.</p>

Bee Positive: Design for Awareness

<p>This thesis aims to create a museum dedicated to awareness, research, and education, in an attempt to preserve the declining bee population. It focuses on the Native Bees of New Zealand in conjunction with introduced bees. The architectural design intention for the bee museum aims to encapsulate the life and biology of the bee through an informative experience of current issues, by delving into the current world in which bees exist, as well as an ephemeral architectural expression based on organic elements occurring in nature. The aim is to adhere to an emotional as well as a cognitive human response for the sake of forming an empathetic connection between the occupier and the architectural subject. This has the potential to aid the bee population through a captivating and informative design, raising further awareness as to what the issue is and how it can potentially be resolved through public initiative. The promotion of bee conservation in New Zealand may have a prospective ecological impact on a national scale and may subsequently have the potential to work as an example for other countries in their approach to this global concern.</p>

Effects of Auditory Stimuli on Beat-Synchronized Long Distance Walking: Part A - Energize on Country Music

In well documented studies, walking and music have independently shown substantial medical, health, productivity, and other human benefits. When music is combined with walking, and especially when the walking is done in synchrony to the beat, the music can stimulate faster walking without apparent awareness, the “velocity effect”. Some studies have reported that music that is either familiar, more enjoyable, and/or has higher “groove” tends to be more stimulating, and that some music can actually be sedating resulting in a slower speed relative to that of walking to a metronome at the same cadence. Research illuminating the velocity effect has mostly been conducted over relatively short stepping distances in a laboratory or similar outdoor setting. The current study examines walking on a real-world long distance outdoor track with a single genre of music that was at least somewhat familiar and somewhat enjoyable to the test subject. In this study, the test subject stepped in self-instructed synchrony with confirmed high accuracy to two types of auditory stimuli – either to the beat of a metronome (a presumed neutral source or what might be considered a most rudimentary form of music), or to the beat of a broad-spectrum of country music continuously over a 2-mile course. Nine metronome tempos and twenty-one country music tempos were examined in a walkable range of 90 to 130 beats per minute (BPM), and the effects of the music and metronome on walking performance were examined and quantified. Overall, the mix of country music was significantly more energizing than the metronome providing a relatively consistent 10% increase in step length and a resulting 10% increase in speed over the entire tempo/cadence range. Speed as a function of tempo was essentially linear in the beat range for both auditory stimuli with an apparent increase in speed relative to the trendlines occurring near 120 BPM, a preferred human response frequency reported in some prior investigations.

Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly manifestation. This perspective focuses on the contribution of the recently discovered interaction of SARS-CoV-2 Spike protein with neuropilin 1 (NRP1) receptor, NRP1 as a virus entry receptor for SARS-CoV-2, its role in different physiologic and pathologic conditions, and the potential to target the Spike–NRP1 interaction to combat virus infectivity and severe disease manifestations.