Design and performance of an integrated fluorescence, polarized fluorescence, and Brewster angle microscope/Langmuir trough assembly for the study of lung surfactant monolayers

1997 ◽  
Vol 68 (6) ◽  
pp. 2574-2582 ◽  
Author(s):  
Michael M. Lipp ◽  
Ka Yee C. Lee ◽  
Joseph A. Zasadzinski ◽  
Alan J. Waring
Keyword(s):  
Lung Surfactant ◽  
Brewster Angle ◽  
Langmuir Trough ◽  
Polarized Fluorescence ◽  
Surfactant Monolayers ◽  
And Performance

scholarly journals Interfacial curvature effects on the monolayer morphology and dynamics of a clinical lung surfactant

2017 ◽  
Vol 115 (2) ◽  
pp. E134-E143 ◽  
Author(s):  
Amit Kumar Sachan ◽  
Joseph A. Zasadzinski
Keyword(s):  
Lung Surfactant ◽  
Morphological Transition ◽  
Surfactant Adsorption ◽  
Langmuir Trough ◽  
Planar Surface ◽  
Lung Surfactants ◽  
Surfactant Monolayers ◽  
Curvature Effects ◽  
And Function ◽  
Micrometer Scale

The morphology of surfactant monolayers is typically studied on the planar surface of a Langmuir trough, even though most physiological interfaces are curved at the micrometer scale. Here, we show that, as the radius of a clinical lung surfactant monolayer-covered bubble decreases to ∼100 µm, the monolayer morphology changes from dispersed circular liquid-condensed (LC) domains in a continuous liquid-expanded (LE) matrix to a continuous LC linear mesh separating discontinuous LE domains. The curvature-associated morphological transition cannot be readily explained by current liquid crystal theories based on isotropic domains. It is likely due to the anisotropic bending energy of the LC phase of the saturated phospholipids that are common to all natural and clinical lung surfactants. This continuous LC linear mesh morphology is also present on bilayer vesicles in solution. Surfactant adsorption and the dilatational modulus are also strongly influenced by the changes in morphology induced by interfacial curvature. The changes in morphology and dynamics may have physiological consequences for lung stability and function as the morphological transition occurs at alveolar dimensions.

scholarly journals The role of SP-B1–25 peptides in lung surfactant monolayers exposed to gold nanoparticles

2020 ◽  
Vol 22 (27) ◽  
pp. 15231-15241
Author(s):  
Sheikh I. Hossain ◽  
Neha S. Gandhi ◽  
Zak E. Hughes ◽  
Suvash C. Saha
Keyword(s):  
Gold Nanoparticles ◽  
Lung Surfactant ◽  
Breathing Cycle ◽  
First Line ◽  
Surfactant Monolayers ◽  
Inhaled Nanoparticles

Lung surfactant monolayer’s (acts as the first line barrier for inhaled nanoparticles) components (lipids and peptides) rearrange themselves by the influence of exposed gold nanoparticles at various stages of the breathing cycle.

The model of the action mechanism of SP-C in the lung surfactant monolayers

2007 ◽  
Vol 57 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Dan Li ◽  
Zuoxiang Zeng ◽  
Weilan Xue ◽  
Yali Yao
Keyword(s):  
Lung Surfactant ◽  
Action Mechanism ◽  
Surfactant Monolayers
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