scholarly journals Continuous perfusion of pulmonary arteries during total cardiopulmonary bypass favorably affects levels of circulating adhesion molecules and lung function

2001 ◽  
Vol 122 (2) ◽  
pp. 242-248 ◽  
Author(s):  
Takaaki Suzuki ◽  
Tsutomu Ito ◽  
Ichiro Kashima ◽  
Koji Teruya ◽  
Toyoki Fukuda
Author(s):  
Renata Calciolari Rossi ◽  
Raquel Anonni ◽  
Diogenes Seraphim Ferreira ◽  
Luiz Fernando Ferraz da Silva ◽  
Thais Mauad

Abstract Background There is interest in better understanding vessel pathology in asthma, given the findings of loss of peripheral vasculature associated with disease severity by imaging and altered markers of endothelial activation. To date, vascular changes in asthma have been described mainly at the submucosal capillary level of the bronchial microcirculation, with sparse information available on the pathology of bronchial and pulmonary arteries. The aim of this study was to describe structural and endothelial activation markers in bronchial arteries (BAs) and pulmonary arteries (PAs) of asthma patients who died during a fatal asthma attack. Methods Autopsy lung tissue was obtained from 21 smoking and non-smoking patients who died of an asthma attack and nine non-smoking control patients. Verhoeff–Masson trichrome staining was used to analyse the structure of arteries. Using immuno-histochemistry and image analyses, we quantified extracellular matrix (ECM) components (collagen I, collagen III, versican, tenascin, fibronectin, elastic fibres), adhesion molecules [vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1)] and markers of vascular tone/dysfunction [endothelin-1 (ET-1) and angiotensin II type 2 receptor (AT2)] in PAs and BAs. Results There were no significant differences in ECM components, ICAM-1, ET-1 or AT2 between asthma patients and controls. Smoking asthma patients presented with decreased content of collagen III in both BA (p = 0.046) and PA (p = 0.010) walls compared to non-smoking asthma patients. Asthma patients had increased VCAM-1 content in the BA wall (p = 0.026) but not in the PA wall. Conclusion Our data suggest that the mechanisms linking asthma and arterial functional abnormalities might involve systemic rather than local mediators. Loss of collagen III in the PA was observed in smoking asthma patients, and this was compatible with the degradative environment induced by cigarette smoking. Our data also reinforce the idea that the mechanisms of leukocyte efflux via adhesion molecules differ between bronchial and pulmonary circulation, which might be relevant to understanding and treating the distal lung in asthma.


1999 ◽  
Vol 20 (2) ◽  
pp. 113-125 ◽  
Author(s):  
A. Tárnok ◽  
J. Hambsch ◽  
F. Emmrich ◽  
U. Sack ◽  
J. van Son ◽  
...  

2000 ◽  
Vol 9 (3) ◽  
pp. A185
Author(s):  
Michael P. Vallely ◽  
Paul G. Bannon ◽  
Clifford F. Hughes ◽  
Leonard Kritharides

2003 ◽  
Vol 11 (3) ◽  
pp. 198-202 ◽  
Author(s):  
Minxin Wei ◽  
Jari Laurikka ◽  
Pekka Kuukasjärvi ◽  
Erkki Pehkonen ◽  
Matti Tarkka

Plasma levels of sE-selectin, sP-selectin, and sICAM-1 were measured before anesthesia and at 0.5, 4, and 20 hours after cardiopulmonary bypass in 37 men undergoing coronary artery bypass surgery. Plasma sE-selectin remained close to the preoperative levels. The levels of sP-selectin increased significantly from 46.5 ± 15.3 ng·mL−1 to 69.3 ± 39.6 ng·mL−1 at 0.5 hours, 84.1 ± 45.5 ng·mL−1 at 4 hours, and 79.6 ± 35.5 ng·mL−1 at 20 hours. Plasma sICAM-1 levels decreased 0.5 hours after cardiopulmonary bypass, recovered at 4 hours, and showed a significant increase at 20 hours. The changes in plasma levels of adhesion molecules did not correlate with the duration of bypass or aortic crossclamping, hemodynamics, or creatine kinase-MB levels. However, sE-selectin and sICAM-1 levels increased considerably more in patients who needed norepinephrine in the intensive care unit. These results indicate that the transient changes in plasma levels of soluble adhesion molecules are not associated with postoperative myocardial injury in low-risk coronary grafting, although they correlate with the need for a vasopressor.


2006 ◽  
Vol 81 (3) ◽  
pp. 896-901 ◽  
Author(s):  
Xiangming Fan ◽  
Yinglong Liu ◽  
Qiang Wang ◽  
Cuntao Yu ◽  
Bo Wei ◽  
...  

2011 ◽  
Vol 25 (3) ◽  
pp. S27
Author(s):  
Zsófia Csorba ◽  
Dorottya Czövek ◽  
Gábor Bogáts ◽  
Ferenc Peták ◽  
Barna Babik

1999 ◽  
Vol 118 (5) ◽  
pp. 930-937 ◽  
Author(s):  
Marcus K. Ilton ◽  
Paul E. Langton ◽  
Marcia L. Taylor ◽  
Neil L.A. Misso ◽  
Mark Newman ◽  
...  

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