Strategies to reverse lung function deterioration to cardiopulmonary bypass: Comparison of ventilation management and/or bronchodilator therapies

2016 ◽  
Author(s):  
Ferenc Peták ◽  
Adam L. Balogh ◽  
Gergely H. Fodor ◽  
Edit Vigh ◽  
Roberta Sudy ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Lung Function ◽  
Ventilation Management

Lung Perfusion With Clarithromycin Ameliorates Lung Function After Cardiopulmonary Bypass

2006 ◽  
Vol 81 (3) ◽  
pp. 896-901 ◽  
Author(s):  
Xiangming Fan ◽  
Yinglong Liu ◽  
Qiang Wang ◽  
Cuntao Yu ◽  
Bo Wei ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Lung Function ◽  
Lung Perfusion

O-63 Sevoflurane diminishes lung function deterioration caused by cardiopulmonary bypass

2011 ◽  
Vol 25 (3) ◽  
pp. S27
Author(s):  
Zsófia Csorba ◽  
Dorottya Czövek ◽  
Gábor Bogáts ◽  
Ferenc Peták ◽  
Barna Babik
Keyword(s):  
Cardiopulmonary Bypass ◽  
Lung Function ◽  
O 63

scholarly journals The Effect of Optimized Ultrafiltration on Perioperative Pulmonary Function During Cardiopulmonary Bypass in Infants Under 10 kg

2021 ◽  
Vol 9 ◽  
Author(s):  
Jianhong Niu ◽  
Guangdi Zhai ◽  
Aibin Zheng ◽  
Juanying Zhou ◽  
Shengqi Jiang ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Treatment Group ◽  
Lung Function ◽  
Pulmonary Function ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Combination Method ◽  
Control Group ◽  
Acid Base Balance ◽  
Significant Difference

Objective: This study aims to investigate the effect of optimized ultrafiltration on perioperative electrolytes, acid–base balance, and pulmonary function during cardiopulmonary bypass (CPB) in infants with low body weight (under 10 kg), using traditional balanced ultrafiltration and modified ultrafiltration.Methods: A total of 30 children who underwent surgical correction for congenital heart disease in Changzhou Children's Hospital between January 2018 and December 2019 were randomly divided into two groups. In the treatment group, ultrafiltration pre-treatment was carried out with blood-containing priming fluid prior to CPB. Balanced ultrafiltration was performed during the operation, and optimized and modified ultrafiltration were conducted before closing and extubation. In the control group, traditional balanced ultrafiltration was used during the operation, and a modified ultrafiltration combination was used before closing and extubation. Indexes such as blood gas analysis and electrolytes were measured perioperatively, and pulmonary function was observed.Results: No deaths were reported in either group. The ventilator-assisted breathing time was shorter in the treatment group than in the control group (P < 0.05). The indexes of the treatment group were closer than those of the control group to the optimal physiological values. The concentrations of potassium ion (K+), lactate (Lac), and blood glucose (Glu) decreased, and there was significant difference between the two groups (P < 0.05) at the end of CPB. Hemoglobin (Hb) and hematocrit (HCT) in the treatment group increased (P < 0.01). Alveolar-arterial differences for oxygen (A-aDO2) and respiratory index (RI) increased significantly in both groups after operation. Children in the treatment group began to recover lung function earlier than children in the control group. Both A-aDO2 and RI were lower in the treatment group than in the control group at each time point after operation (P < 0.05).Conclusion: Optimizing and modifying the traditional ultrafiltration combination method can effectively shorten the ultrafiltration time, reduce the adverse impacts of the ultrafiltration technique, and improve the lung function of infants after operation.

Extracorporeal respiratory and cardiac support techniques in the ICU

2016 ◽  
Author(s):  
Claire Westrope ◽  
Giles Peek
Keyword(s):  
Cardiopulmonary Bypass ◽  
Lung Function ◽  
Cardiac Failure ◽  
Life Support ◽  
General Term ◽  
Swine Flu ◽  
Extra Corporeal Membrane Oxygenation ◽  
Temporary Support ◽  
Extracorporeal Therapy ◽  
Mechanical Devices

Extra corporeal life support (ECLS) is an essential tool for the modern intensivist and surgeon. The addition of extracorporeal therapy should be considered in all cases when pathology is potentially reversible and conventional therapy is clearly failing. ECLS is a general term to describe prolonged, but temporary support of heart and lung function using mechanical devices, which has developed as an extension of cardiopulmonary bypass techniques used in the operating theatre. Use in adult severe respiratory and cardiac failure is increasing following significant advances in ECLS techniques learnt from paediatric and neonatal experiences, and successful use of extra corporeal membrane oxygenation in the 2009 and 2001 H1N1 (swine flu) outbreaks. This chapter describes the techniques required for providing successful ECLS in adult respiratory and cardiac failure.

DOPAMINE REVERSES LUNG FUNCTION DETERIORATION AFTER CARDIOPULMONARY BYPASS WITHOUT AFFECTING GAS EXCHANGE

2021 ◽  
Author(s):  
Ferenc Peták ◽  
Ádám L. Balogh ◽  
Péter Hankovszky ◽  
Gergely H. Fodor ◽  
József Tolnai ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Lung Function ◽  
Gas Exchange

Chest X-ray Image Analysis and Penehyclidine Hydrochloride Postconditioning Influence of Lung Ischemia Reperfusion Injury

2020 ◽  
Vol 10 (12) ◽  
pp. 2834-2841
Author(s):  
Chunlei Zhang ◽  
Jun Ma
Keyword(s):  
Image Analysis ◽  
Cardiopulmonary Bypass ◽  
Lung Function ◽  
Heart Surgery ◽  
Mapk Pathway ◽  
Medical Image Analysis ◽  
High Dose ◽  
X Ray ◽  
Chest X Ray ◽  
Penehyclidine Hydrochloride

Purpose: We analyze chest X-ray diagnosis results of patients undergoing cardiopulmonary bypass heart surgery in intensive care unit (ICU). In our previous study, we found that penehyclidine hydrochloride (PHC) preconditioning pretects lung function and reduced the apoptosis. Although preconditioning is effective, this clinical treatment is often given only when symptoms appear, when postconditioning is easier to administer. In this study, after confirming the lung condition via medical image analysis, we aimed to look the effect of high-dose penehyclidine hydrochloride postconditioning in lung after I/R in rats, and the apoptosis mechanisms involved. Methods: Chest X-ray was taken in 256 adult patients under cardiopulmonary bypass with heart syurery. Medical image analysis was preliminarily performed, the diagnostic results were analyzed. Rats were subjected to ischemia in left lung 45 min, and then 2 h reperfusion, and treated with PHC. We then observed the effects of PHC on the following: lung function, lung injury, oxidative stress, rate of apoptosis of lung cells, apoptosis-related proteins, and the p38 MAPK pathway. Results: Analysis results of chest X-ray suggest multiple pulmonary complications after cardiopulmonary bypass heart surgery. The laboratory results showed that high-dose penehyclidine hydrochloride postconditioning significantly protected lung function, reduced oxidative stress and apoptosis of the lungs caused by reperfusion, and inhibited activation of the p38 MAPK pathway. Conclusion: Analysis results of chest X-ray show multiple pulmonary complications after cardiopulmonary bypass heart surgery. This study suggests that high-dose penehyclidine hydrochloride can treat lung I/R injury.

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