Studies of Australian soft corals. IX. A novel nor-diterpene from the soft coral Sinularia leptoclados

1978 ◽  
Vol 31 (9) ◽  
pp. 2049 ◽  
Author(s):  
BF Bowden ◽  
JC Coll ◽  
SJ Mitchell ◽  
J Mulder ◽  
GJ Stokie
Keyword(s):  
Single Crystal ◽  
Spectroscopic Data ◽  
Soft Coral ◽  
Parent Compound ◽  
Soft Corals ◽  
X Ray

The structure of a novel nor-cembranoid diterpene of formula C19H24O6 (1) is reported. The compound was extracted from the soft coral Sinularia leptoclados, and spectroscopic data were collected on the parent compound (1) and a series of derivatives. It was not possible to assign an unambiguous structure on purely spectroscopic grounds, and so single-crystal X-ray analysis was used to prove the structure (1): (4R*,8S*,11R*,13S*,14R*)-14-hydroxy-4-isopropenyl-11-methyl-6,9-dioxo-8,11-epoxycyclotetradec-1-ene-1,13-carbolactone.

Studies of Australian Soft Corals. XV. The Structure of Pachyclavulariadiol, a Novel Furano-Diterpene from Pachyclavularia violacea

1979 ◽  
Vol 32 (10) ◽  
pp. 2265 ◽  
Author(s):  
BF Bowden ◽  
JC Coll ◽  
SJ Mitchell ◽  
CL Raston ◽  
GJ Stokie ◽  
...  
Keyword(s):  
Single Crystal ◽  
Diffraction Study ◽  
Furan Ring ◽  
Soft Coral ◽  
Soft Corals ◽  
X Ray Diffraction ◽  
Isopropyl Group ◽  
X Ray ◽  
Naturally Occurring

.Pachyclavulariadiol (3) and its naturally occurring mono-(4) and di-acetylated (5) derivatives have been isolated from the soft coral Pachyclavularia violacea. Their structures were deduced spectroscopically and confirmed by a single-crystal X-ray diffraction study on the diol(3). Each compound is shown to be a highly functionalized cembranoid diterpene with the isopropyl group elaborated as a furan ring.

Studies of Australian Soft Corals. XLI. Structure Determination of a New Sesquiterpene From Xenia novae-britanniae and an Investigation of a Xenia Species

1987 ◽  
Vol 40 (8) ◽  
pp. 1483 ◽  
Author(s):  
BF Bowden ◽  
JC Coll ◽  
LM Engelhardt ◽  
A Heaton ◽  
AH White
Keyword(s):  
Single Crystal ◽  
Structure Determination ◽  
Soft Coral ◽  
Soft Corals ◽  
X Ray ◽  
X Ray Crystallography ◽  
Relative Stereochemistry

.A novel sesquiterpene (1 Z,2R*,4R*,7S*,11S*)-3,3,7,11-tetramethyltricyclo[6.3.0.02,4]undec-1(8)-en-4-ol (3) was isolated from the soft coral Xenia novae-britanniae. Its structure was tentatively deduced by n.m.r. spectroscopy, and the structure with relative stereochemistry was confirmed by single-crystal X-ray crystallography. Investigation of a Xenia species afforded the known metabolite waixenicin -A previously isolated from Anthelia edmondsoni .

Studies of Australian soft corals. VIII. A chemical and crystallographic study of a novel bicyclic diterpene alcohol with a rearranged skeleton from an unknown species of soft coral

1978 ◽  
Vol 31 (9) ◽  
pp. 2039 ◽  
Author(s):  
BF Bowden ◽  
JC Coll ◽  
SJ Mitchell ◽  
GJ Stokie ◽  
JF Blount
Keyword(s):  
Single Crystal ◽  
Spectroscopic Analysis ◽  
Soft Coral ◽  
Soft Corals ◽  
X Ray ◽  
Crystallographic Study ◽  
Unknown Species ◽  
Diterpene Alcohol

The structure of a novel bicyclic diterpene alcohol is reported and shown to be (3Z,5E,9E,1R*,-7R*,12aR*)-1-isopropyl-6,10,12a-trimethyl- 1,2,4,7,8,11,12,12a-octahydrocyclopentacycloundecen-7-ol(1a). It is structurally related to the known diterpene (2) from Dollabella californica. However, in (1a), there has been a methyl migration resulting in a rearranged isoprenoid skeleton. The structure was solved by single-crystal X-ray analysis, after spectroscopic analysis failed to yield an unambiguous structure.

New iboga-type alkaloids from Ervatamia hainanensis

RSC Advances ◽  
2016 ◽  
Vol 6 (36) ◽  
pp. 30277-30284 ◽  
Author(s):  
Zhi-Wen Liu ◽  
Xiao-Jun Huang ◽  
Han-Lin Xiao ◽  
Guo Liu ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Single Crystal ◽  
Spectroscopic Data ◽  
X Ray Diffraction ◽  
X Ray

The structures and absolute configurations of seven new iboga-type alkaloids 1–7 were determined by spectroscopic data, Mosher's method, single crystal X-ray diffraction and ECD analyses.

Studies of Australian soft corals. XXXII. The structure determination of degraded xenicin-type diterpenes from several Efflatounaria species

1983 ◽  
Vol 36 (11) ◽  
pp. 2279 ◽  
Author(s):  
BF Bowden ◽  
JC Coll ◽  
VA Patrick ◽  
DM Tapiolas
Keyword(s):  
Single Crystal ◽  
Chemical Transformation ◽  
Structure Determination ◽  
High Field ◽  
Soft Corals ◽  
X Ray ◽  
The Third

Three new diterpenes have been isolated from soft corals of the genus Efflatounaria (Coelenterata, Octocorallia, Alcyonacea, Xeniidae). The structure of the first compound (4) was elucidated on the basis of high-field 1H n.m.r. spectroscopy while that of the second metabolite (5) was determined by single-crystal X-ray analysis. The third diterpene (6) was structurally related to (5), and its structure was confirmed by chemical transformation. All three diterpenes can be derived from xenicin-type precursors, by cleavage and recyclization.

scholarly journals The structure of fusarochromanone: new mycotoxin from Fusariumroseum, "Graminearum"

1986 ◽  
Vol 64 (7) ◽  
pp. 1258-1261 ◽  
Author(s):  
Sadanand V. Pathre ◽  
William B. Gleason ◽  
Yin-Wan Lee ◽  
Chester J. Mirocha
Keyword(s):  
Single Crystal ◽  
Spectroscopic Data ◽  
Ring Structure ◽  
Toxic Principle ◽  
X Ray ◽  
Tibial Dyschondroplasia ◽  
Toxic Cultures

An isolate of Fusariumroseum "Graminearum" obtained from overwintered oats in Alaska produced toxic cultures when grown on rice. The toxic principle called fusarochromanone isolated from these cultures reproduced the signs of tibial dyschondroplasia in poultry and also reduced hatchability of fertile eggs. Spectroscopic data (nmr, ir, and ms) indicated the mycotoxin to be a chromanone derivative. The chromanone ring structure was also confirmed by single crystal X-ray.

New quinolinone alkaloids from the heartwood of, Euxylophora paraensis

1981 ◽  
Vol 34 (8) ◽  
pp. 1625 ◽  
Author(s):  
L Jurd ◽  
RY Wong
Keyword(s):  
Single Crystal ◽  
Spectroscopic Data ◽  
X Ray Diffraction ◽  
X Ray

The heartwood of Euxylophora paraensis Hub. (Rutaceae) has given N-methylflindersine (2),spectabiline (3), skimmianine (4) and two new alkaloids, identified from spectroscopic data as 4-hydroxy-2,2,6-trimethyl-3,4,5,6-tetrahydro-2H-pyrano[3,2-c]quinolin-5-one (5) and 4-(2,3-dihydroxy-3-methylbutoxy)-1-methylquinolin-2(1H)-one (6). Five new dimeric quinolinone alkaloids, C30H30N2O4, were isolated. The structure of one of these, paraensidimerin D, has now been shown by single-crystal X-ray diffraction methods to be (11), viz. (6aα,7α,14aα)-6,6,9,16- tetramethyl-7-(2-methylprop-1-enyl)-6,6a,7,9,14a,16-hexahydro-8H,15H- quino[3'',4'':5',6'] pyrano [2',3':4,5] pyrano-[3,2-c]quinoline-8,15- dione.

scholarly journals ISOLATION AND STRUCTURAL ELUCIDATION OF A NEW DEPSIDE OF LICHEN Everniopsis trulla

2021 ◽  
Vol 87 (2) ◽  
pp. 97-106
Author(s):  
Olivio Nino Castro ◽  
Jesús López Rodilla ◽  
Sofia Pombal ◽  
Francisca Sanz González ◽  
Julio Santiago Contreras
Keyword(s):  
Mass Spectrometry ◽  
Melting Point ◽  
Hydrogen Bonds ◽  
Single Crystal ◽  
Spectroscopic Data ◽  
Intermolecular Forces ◽  
X Ray Diffraction ◽  
Intermolecular Hydrogen Bonds ◽  
X Ray ◽  
Uv Visible

In this research, a new depside of the lichen Everniopsis trulla has been isolated. The extraction was carried out to 400 g of dry sample and ground with ethanol for 3 repetitions, then, it was fractionated by applying column chromatography with the CHCl3-MeOH system and purified by recrystallization with MeOH-Acetone (1: 1); Finally, white crystals in the form of needles (solid C) with a melting point of 198 ° C were obtained, whose structure was elucidated based on spectroscopic data (UV-Visible, IR, NMR-H1, NMR-C13, mass spectrometry and single crystal X-ray diffraction). According to the Science Finder databases, it is a new depside, called trullarin, and it is observed that molecular packing is influenced by both intramolecular and intermolecular forces. Intermolecular hydrogen bonds of O - H -O type binds neighboring molecules forming dimers.

scholarly journals Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01

Marine Drugs ◽  
2019 ◽  
Vol 17 (8) ◽  
pp. 483 ◽  
Author(s):  
Pei Qiu ◽  
Zhaoming Liu ◽  
Yan Chen ◽  
Runlin Cai ◽  
Guangying Chen ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Secondary Metabolites ◽  
Single Crystal ◽  
Absolute Configuration ◽  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
X Ray Diffraction ◽  
X Ray ◽  
Ic50 Values ◽  
New Metabolites

Four new metabolites, asperchalasine I (1), dibefurin B (2) and two epicoccine derivatives (3 and 4), together with seven known compounds (5–11) were isolated from a mangrove fungus Mycosphaerella sp. SYSU-DZG01. The structures of compounds 1–4 were established from extensive spectroscopic data and HRESIMS analysis. The absolute configuration of 1 was deduced by comparison of ECD data with that of a known structure. The stereostructures of 2–4 were further confirmed by single-crystal X-ray diffraction. Compounds 1, 8 and 9 exhibited significant α-glucosidase inhibitory activity with IC50 values of 17.1, 26.7 and 15.7 μM, respectively. Compounds 1, 4, 6 and 8 showed antioxidant activity by scavenging DPPH· with EC50 values ranging from 16.3 to 85.8 μM.

scholarly journals Anti-inflammatory Anthraquinones from the Crinoid Himerometra magnipinna

2015 ◽  
Vol 10 (2) ◽  
pp. 1934578X1501000
Author(s):  
Yen-You Lin ◽  
Su-June Tsai ◽  
Michael Y. Chiang ◽  
Zhi-Hong Wen ◽  
Jui-Hsin Su
Keyword(s):  
Single Crystal ◽  
Diffraction Analysis ◽  
Absolute Configuration ◽  
Spectroscopic Data ◽  
Test Compound ◽  
X Ray Diffraction ◽  
X Ray ◽  
Anti Inflammatory ◽  
Raw264.7 Macrophage

Chemical investigation of a crinoid Himerometra magnipinna has afforded three anthraquinones (1–3), including one new metabolite, (+)-rhodoptilometrin (1). The structures of these compounds were elucidated on the basis of their spectroscopic data and the absolute configuration of 1 was further confirmed by single-crystal X-ray diffraction analysis. In the in vitro anti-inflammatory effects test, compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells.

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