A Synthetic Route to Epoxyalkyl β-Laminaribiosides, Especially Suitable for Radiolabeling

1994 ◽  
Vol 47 (9) ◽  
pp. 1805 ◽  
Author(s):  
WM Best ◽  
RV Stick ◽  
DMG Tilbrook
Keyword(s):  
Synthetic Route ◽  
Benzyl Ethers ◽  
Derivatives Of

The major products in the controlled benzylation (NaH/PhCH2Cl) of allyl and but-3-enyl β-D-glucopyranosides were the 2,4,6-tri-O-benzyl ethers. Subsequent glycosidations of these tribenzyl ethers gave derivatives of allyl and but-3-enyl β- laminaribioside, the latter being subsequently transformed into 3,4-epoxybutyl β- laminaribioside.

scholarly journals α,ß-Didehydrosuberoylanilide hydroxamic acid (DDSAHA) as precursor and possible analogue of the anticancer drug SAHA

2019 ◽  
Vol 15 ◽  
pp. 2524-2533 ◽  
Author(s):  
Shital K Chattopadhyay ◽  
Subhankar Ghosh ◽  
Sarita Sarkar ◽  
Kakali Bhadra
Keyword(s):  
Anticancer Drug ◽  
Hela Cells ◽  
Hydroxamic Acid ◽  
Suberoylanilide Hydroxamic Acid ◽  
Oxygen Species ◽  
Synthetic Route ◽  
Metathesis Reaction ◽  
Cross Metathesis ◽  
Terminal Alkene ◽  
Derivatives Of

An alternate synthetic route to the important anticancer drug suberoylanilide hydroxamic acid (SAHA) from its α,ß-didehydro derivative is described. The didehydro derivative is obtained through a cross metathesis reaction between a suitable terminal alkene and N-benzyloxyacrylamide. Some of the didehydro derivatives of SAHA were preliminarily evaluated for anticancer activity towards HeLa cells. The administration of the analogues caused a significant decrease in the proliferation of HeLa cells. Furthermore, one of the analogues showed a maximum cytotoxicity with a minimum GI50 value of 2.5 µg/mL and the generation of reactive oxygen species (ROS) as some apoptotic features.

ChemInform Abstract: A Convenient Synthetic Route from Isatin N-Mannich Bases to Nitrogen-Containing Derivatives of Isoindigo.

ChemInform ◽  
2011 ◽  
Vol 42 (17) ◽  
pp. no-no
Author(s):  
Andrei V. Bogdanov ◽  
Vladimir F. Mironov ◽  
Lenar I. Musin ◽  
Rashid Z. Musin ◽  
Dmitry B. Krivolapov ◽  
...  
Keyword(s):  
Mannich Bases ◽  
Synthetic Route ◽  
Derivatives Of

scholarly journals Coupling of C-nitro-NH-azoles with arylboronic acids. A route to N-aryl-C-nitroazoles

2013 ◽  
Vol 9 ◽  
pp. 1517-1525 ◽  
Author(s):  
Marta K Kurpet ◽  
Aleksandra Dąbrowska ◽  
Małgorzata M Jarosz ◽  
Katarzyna Kajewska-Kania ◽  
Nikodem Kuźnik ◽  
...  
Keyword(s):  
Sodium Hydroxide ◽  
Coupling Reaction ◽  
Copper Salt ◽  
Synthetic Route ◽  
Arylboronic Acids ◽  
Derivatives Of

A method for the synthesis of N-aryl-C-nitroazoles is presented. A coupling reaction between variously substituted arylboronic acids and 3(5)-nitro-1H-pyrazole catalyzed by copper salt has been carried out in methanol in the presence of sodium hydroxide to afford the desired N-aryl-C-nitroazoles in good yields. This synthetic route has also been successfully applied to obtain N-phenyl derivatives of 4-nitropyrazole, 2-nitroimidazole, 4(5)-nitroimidazole and 3-nitro-1,2,4-triazole.

scholarly journals Solid-Phase Synthetic Route to Multiple Derivatives of a Fundamental Peptide Unit

Molecules ◽  
2010 ◽  
Vol 15 (7) ◽  
pp. 4961-4983 ◽  
Author(s):  
William L. Scott ◽  
Ziniu Zhou ◽  
Paweł Zajdel ◽  
Maciej Pawłowski ◽  
Martin J. O’Donnell
Keyword(s):  
Solid Phase ◽  
Synthetic Route ◽  
Peptide Unit ◽  
Derivatives Of

A novel synthetic route to 2-alkylpropane-1,3-sultones and its application to the synthesis of 2-alkyl derivatives of tramiprosate

2007 ◽  
Vol 48 (49) ◽  
pp. 8587-8589 ◽  
Author(s):  
Benoit Bachand ◽  
Mohamed Atfani ◽  
Bita Samim ◽  
Sophie Lévesque ◽  
Daniel Simard ◽  
...  
Keyword(s):  
Synthetic Route ◽  
Alkyl Derivatives ◽  
Derivatives Of

A Practical Synthesis of 3β-Amino-5-Cholestene

2013 ◽  
Vol 830 ◽  
pp. 151-154 ◽  
Author(s):  
Yue Hai You ◽  
Shan Shan Gong ◽  
Qi Sun
Keyword(s):  
Practical Method ◽  
Synthetic Route ◽  
Medicinal Value ◽  
Practical Synthesis ◽  
Derivatives Of ◽  
Substantial Interest

Derivatives of 3β-amino-5-cholestene are of substantial interest to chemical biologists and have potential medicinal value. A novel and practical method for the preparation of 3β-amino-5-cholestene from inexpensive cholesterol has been developed. To synthesize the epicholesterol intermediate, the KO2 method reported by Corey and coworkers was applied in this synthetic route and solved the problems of the known synthetic route involving epicholesterol intermediate.

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