scholarly journals Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice

2012 ◽  
Vol 109 (27) ◽  
pp. 10885-10890 ◽  
Author(s):  
T. Masuda ◽  
K. Itoh ◽  
H. Higashitsuji ◽  
H. Higashitsuji ◽  
N. Nakazawa ◽  
...  
Keyword(s):  
Germ Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Male Germ Cells ◽  
Immature Male

DECREASED EXPRESSION OF COLD-INDUCIBLE RNA-BINDING PROTEIN (CIRP) IN MALE GERM CELLS AT ELEVATED TEMPERATURE

1999 ◽  
pp. 343 ◽  
Author(s):  
Shozo Danno ◽  
Tadashi Matsuda ◽  
Hiroyuki Nishiyama ◽  
Hiromu Tokuchi ◽  
Osamu Yoshida ◽  
...  
Keyword(s):  
Elevated Temperature ◽  
Germ Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Male Germ Cells

scholarly journals The RNA Binding Protein SAM68 Transiently Localizes in the Chromatoid Body of Male Germ Cells and Influences Expression of Select MicroRNAs

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39729 ◽  
Author(s):  
Valeria Messina ◽  
Oliver Meikar ◽  
Maria Paola Paronetto ◽  
Sara Calabretta ◽  
Raffaele Geremia ◽  
...  
Keyword(s):  
Germ Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Chromatoid Body ◽  
Male Germ Cells

scholarly journals The DNA/RNA-binding protein MSY2 marks specific transcripts for cytoplasmic storage in mouse male germ cells

2005 ◽  
Vol 102 (5) ◽  
pp. 1513-1518 ◽  
Author(s):  
J. Yang ◽  
S. Medvedev ◽  
P. P. Reddi ◽  
R. M. Schultz ◽  
N. B. Hecht
Keyword(s):  
Germ Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Male Germ Cells

scholarly journals MIWI-independent small RNAs (MSY-RNAs) bind to the RNA-binding protein, MSY2, in male germ cells

2009 ◽  
Vol 106 (30) ◽  
pp. 12371-12376 ◽  
Author(s):  
M. Xu ◽  
S. Medvedev ◽  
J. Yang ◽  
N. B. Hecht
Keyword(s):  
Germ Cells ◽  
Small Rnas ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Male Germ Cells

scholarly journals The Relative Levels of Translin-associated Factor X (TRAX) and Testis Brain RNA-binding Protein Determine Their Nucleocytoplasmic Distribution in Male Germ Cells

2004 ◽  
Vol 279 (30) ◽  
pp. 31514-31523 ◽  
Author(s):  
Yoon Shin Cho ◽  
Vargheese M. Chennathukuzhi ◽  
Mary Ann Handel ◽  
John Eppig ◽  
Norman B. Hecht
Keyword(s):  
Germ Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Factor X ◽  
Male Germ Cells ◽  
Associated Factor ◽  
Nucleocytoplasmic Distribution

scholarly journals The RNA-Binding Protein DND1 Acts Sequentially as a Negative Regulator of Pluripotency and a Positive Regulator of Epigenetic Modifiers Required for Germ Cell Reprogramming

2018 ◽  
Author(s):  
Victor A. Ruthig ◽  
Matthew B. Friedersdorf ◽  
Jason A. Garness ◽  
Steve C. Munger ◽  
Corey Bunce ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Germ Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Embryonic Cell ◽  
Negative Regulator ◽  
Stem Cell Population ◽  
Male Germ Cells ◽  
Mitotic Proliferation

AbstractThe adult spermatogonial stem cell population arises from pluripotent primordial germ cells (PGCs) that enter the fetal testis around embryonic day 10.5 (E10.5). These cells undergo rapid mitotic proliferation, then enter a prolonged period of cell cycle arrest (G1/G0) during which they transition to pro-spermatogonia. In mice homozygous for the Ter mutation in the RNA-binding protein DND1 (DND1Ter/Ter), many germ cells fail to enter G1/G0, and give rise to teratomas, tumors in which many embryonic cell types are represented. To investigate the origin of these tumors, we sequenced the transcriptome of male germ cells in DND1Ter/Ter mutants at E12.5, E13.5, and E14.5, just prior to the formation of teratomas, and correlated this information with direct targets of DND1 identified by DO-RIP-Seq. Consistent with previous results, we found that DND1 controls the down regulation of many genes associated with pluripotency and active cell cycle, including elements of the mTor, Hippo and Bmp/Nodal signaling pathways. However, DND1 targets also include genes associated with male differentiation including a large group of chromatin regulators activated in wild type but not mutant germ cells during the transition between E13.5 and E14.5. These results suggest multiple functions of DND1, and link DND1 to the initiation of epigenetic modifications in male germ cells.

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