scholarly journals Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons

2012 ◽  
Vol 109 (45) ◽  
pp. 18589-18594 ◽  
Author(s):  
S.-Z. Wang ◽  
J. Ou ◽  
L. J. Zhu ◽  
M. R. Green
Keyword(s):  
Transcription Factor ◽  
Sensory Neurons ◽  
Terminal Differentiation ◽  
Olfactory Sensory Neurons

scholarly journals Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
J Roman Arguello ◽  
Liliane Abuin ◽  
Jan Armida ◽  
Kaan Mika ◽  
Phing Chian Chai ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Rna Polymerase Ii ◽  
Sensory Neurons ◽  
Chromatin Accessibility ◽  
Olfactory Sensory Neurons ◽  
Ionotropic Receptor ◽  
Genetic Switch ◽  
Pou Domain ◽  
Guidance Molecule ◽  
Neuronal Guidance

Determining the molecular properties of neurons is essential to understand their development, function and evolution. Using Targeted DamID (TaDa), we characterize RNA polymerase II occupancy and chromatin accessibility in selectedIonotropic receptor(Ir)-expressing olfactory sensory neurons inDrosophila. Although individual populations represent a minute fraction of cells, TaDa is sufficiently sensitive and specific to identify the expected receptor genes. UniqueIrexpression is not consistently associated with differences in chromatin accessibility, but rather to distinct transcription factor profiles. Genes that are heterogeneously expressed across populations are enriched for neurodevelopmental factors, and we identify functions for the POU-domain protein Pdm3 as a genetic switch of Ir neuron fate, and the atypical cadherin Flamingo in segregation of neurons into discrete glomeruli. Together this study reveals the effectiveness of TaDa in profiling rare neural populations, identifies new roles for a transcription factor and a neuronal guidance molecule, and provides valuable datasets for future exploration.

scholarly journals Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons

2019 ◽  
Vol 77 (18) ◽  
pp. 3597-3609 ◽  
Author(s):  
Ya-Zhou Wang ◽  
Hong Fan ◽  
Yu Ji ◽  
Kurt Reynolds ◽  
Ran Gu ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Terminal Differentiation ◽  
Olfactory Sensory Neurons

Identification of genes regulated by transcription factor KLF7 in differentiating olfactory sensory neurons

Gene ◽  
2007 ◽  
Vol 388 (1-2) ◽  
pp. 34-42 ◽  
Author(s):  
Daisuke Kajimura ◽  
Cecilia Dragomir ◽  
Francesco Ramirez ◽  
Friedrich Laub
Keyword(s):  
Transcription Factor ◽  
Sensory Neurons ◽  
Olfactory Sensory Neurons

scholarly journals A critical period terminates the differentiation of olfactory sensory neurons

2020 ◽  
Author(s):  
Shadi Jafari ◽  
Mattias Alenius
Keyword(s):  
Gene Regulation ◽  
Sensory Neurons ◽  
Critical Period ◽  
Odorant Receptor ◽  
Terminal Differentiation ◽  
Olfactory Sensory Neurons ◽  
Genetic Studies ◽  
Vast Number ◽  
Gene Regulatory ◽  
Or Gene

AbstractDevelopment generates a vast number of neuron types and classes. When and how neuronal differentiation end is poorly understood. Here, we show that Drosophila olfactory sensory neurons (OSNs) matures during a critical period and reveal that the differentiation termination mechanism is similar to the mammalian odorant receptor (OR) choice mechanism. We first showed that initiation of Drosophila OR expression required heterochromatin opening and a H3K9me3 demethylase, Kdm4b. Further genetic studies demonstrated that Lsd1 and su(var)3-9, similar to mouse, were required to balance heterochromatin in order to stabilize OR expression. Expression analysis showed that Lsd1, su(var)3-9 increased and Kdm4b decreased during the first two days after eclosion. We further showed that environment changes during the period, but not after, caused permanent transformed Lsd1, su(var)3-9 and Kdm4b expression and altered OR gene regulation. These results together suggest the last step in OSN terminal differentiation to be a gene regulatory critical period.

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