scholarly journals CMS: An adapter molecule involved in cytoskeletal rearrangements

1999 ◽  
Vol 96 (11) ◽  
pp. 6211-6216 ◽  
Author(s):  
K. H. Kirsch ◽  
M.-M. Georgescu ◽  
S. Ishimaru ◽  
H. Hanafusa
Keyword(s):  
Adapter Molecule ◽  
Cytoskeletal Rearrangements

scholarly journals Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats’ Brain and Heart

2021 ◽  
Vol 22 (13) ◽  
pp. 6839
Author(s):  
Ali H. El-Far ◽  
Yaser H. A. Elewa ◽  
Elsayeda-Zeinab A. Abdelfattah ◽  
Abdel-Wahab A. Alsenosy ◽  
Mustafa S. Atta ◽  
...  
Keyword(s):  
Animal Models ◽  
Calcium Binding ◽  
Caspase 3 ◽  
Combination Group ◽  
Preventive Effect ◽  
Group Data ◽  
Adapter Molecule ◽  
The Brain ◽  
Bcl2 Expression

D-galactose (D-gal) administration causes oxidative disorder and is widely utilized in aging animal models. Therefore, we subcutaneously injected D-gal at 200 mg/kg BW dose to assess the potential preventive effect of thymoquinone (TQ) and curcumin (Cur) against the oxidative alterations induced by D-gal. Other than the control, vehicle, and D-gal groups, the TQ and Cur treated groups were orally supplemented at 20 mg/kg BW of each alone or combined. TQ and Cur effectively suppressed the oxidative alterations induced by D-gal in brain and heart tissues. The TQ and Cur combination significantly decreased the elevated necrosis in the brain and heart by D-gal. It significantly reduced brain caspase 3, calbindin, and calcium-binding adapter molecule 1 (IBA1), heart caspase 3, and BCL2. Expression of mRNA of the brain and heart TP53, p21, Bax, and CASP-3 were significantly downregulated in the TQ and Cur combination group along with upregulation of BCL2 in comparison with the D-gal group. Data suggested that the TQ and Cur combination is a promising approach in aging prevention.

scholarly journals Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila

2010 ◽  
Vol 9 (1) ◽  
pp. 9 ◽  
Author(s):  
Silvia Gluderer ◽  
Erich Brunner ◽  
Markus Germann ◽  
Virginija Jovaisaite ◽  
Changqing Li ◽  
...  
Keyword(s):  
Adapter Molecule

scholarly journals Mycobacteria directly induce cytoskeletal rearrangements for macrophage spreading and polarization through TLR2-dependent PI3K signaling

2006 ◽  
Vol 80 (6) ◽  
pp. 1480-1490 ◽  
Author(s):  
Elena B. Lasunskaia ◽  
Mariana N. N. Campos ◽  
Marcelle R. M. de Andrade ◽  
Renato A. DaMatta ◽  
Thereza L. Kipnis ◽  
...  
Keyword(s):  
Pi3k Signaling ◽  
Cytoskeletal Rearrangements

TIR-Domain-Containing Adapter Molecule 2

2012 ◽  
pp. 1866-1866
Author(s):  
João Gonçalves ◽  
Helena Soares ◽  
Norman L. Eberhardt ◽  
Sarah C. R. Lummis ◽  
David R. Soto-Pantoja ◽  
...  
Keyword(s):  
Tir Domain ◽  
Adapter Molecule

scholarly journals SREBP1 drives KRT80-dependent cytoskeletal changes and invasive behavior in endocrine resistant ERα breast cancer

2018 ◽  
Author(s):  
Ylenia Perone ◽  
Aaron J. Farrugia ◽  
Alba Rodriguez Meira ◽  
Balázs Győrffy ◽  
Charlotte Ion ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Invasion ◽  
De Novo ◽  
Regulatory Element ◽  
Leading Edge ◽  
Clinical Endpoints ◽  
Breast Cancer Relapse ◽  
Element Binding Protein ◽  
Cytoskeletal Rearrangements

AbstractApproximately 30% of women diagnosed with ERα breast cancer relapse with metastatic disease following adjuvant treatment with endocrine therapies1,2. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain (TAD)3 undergoes epigenetic reprogramming in cells that develop resistance to aromatase inhibitors (AI), leading to keratin 80 (KRT80) upregulation. In agreement, an increased number of KRT80-positive cells are observed at relapse in vivo while KRT80 expression associates with poor outcome using several clinical endpoints. KRT80 expression is driven by de novo enhancer activation by sterol regulatory element-binding protein 14 (SREBP1). KRT80 upregulation directly promotes cytoskeletal rearrangements at the leading edge, increased focal adhesion maturation and cellular stiffening, which collectively promote cancer cell invasion. Shear-wave elasticity imaging of prospective patients shows that KRT80 levels correlate with stiffer tumors in vivo. Collectively, our data uncover an unpredicted and potentially targetable direct link between epigenetic and cytoskeletal reprogramming promoting cell invasion in response to chronic AI treatment.

Cytoskeletal Rearrangements in Adult Rat Cardiomyocytes in Culture

1995 ◽  
Vol 752 (1 Cardiac Growt) ◽  
pp. 128-130 ◽  
Author(s):  
HANS M. EPPENBERGER ◽  
MONIKA EPPENBERGER-EBERHARDT ◽  
CECILIA HERTIG
Keyword(s):  
Rat Cardiomyocytes ◽  
Adult Rat ◽  
Cytoskeletal Rearrangements
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