scholarly journals Evidence for a protective role of metallothionein-1 in focal cerebral ischemia

1999 ◽  
Vol 96 (22) ◽  
pp. 12870-12875 ◽  
Author(s):  
M. van Lookeren Campagne ◽  
H. Thibodeaux ◽  
N. van Bruggen ◽  
B. Cairns ◽  
R. Gerlai ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Protective Role

scholarly journals Angiopoietin-2 is Vasoprotective in the Acute Phase of Cerebral Ischemia

2012 ◽  
Vol 33 (3) ◽  
pp. 389-395 ◽  
Author(s):  
Léna Marteau ◽  
Samuel Valable ◽  
Didier Divoux ◽  
Simon A Roussel ◽  
Omar Touzani ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Acute Phase ◽  
Focal Cerebral Ischemia ◽  
Neurovascular Unit ◽  
Protective Role ◽  
Lesion Volume ◽  
Ischemic Lesion ◽  
Vessel Growth ◽  
Angiopoietin 2

Most forms of cerebral ischemia are characterized by damage to the entire neurovascular unit, which leads to an increase in the permeability of the blood–brain barrier (BBB). In response to permanent focal cerebral ischemia in mice, we detected an early concomitant increase in the expression of the vascular endothelial growth factor (VEGF), a key inducer of vascular leakage and pathological blood vessel growth, and of angiopoietin-2 (Ang2), which is closely associated with VEGF in vascular remodeling. Thus, the aim of this study was to evaluate the role of Ang2 alone, or in combination with VEGF, in the acute phase of cerebral ischemia. The effect of these angiogenic factors on the ischemic lesion volume was evaluated by magnetic resonance imaging. We observed that timely administration of VEGF exacerbates ischemic damage. In contrast, Ang2 decreases the ischemic volume and this beneficial effect is maintained in the presence of VEGF. This investigation reports, for the first time, a protective role of Ang2 following cerebral ischemia, an action associated with a reduced BBB permeability. We propose that Ang2 represents a pertinent molecular target for the treatment of cerebral ischemia since acute brain damage may be limited by a pharmacological protection of the vascular compartment.

scholarly journals Protective role of isoflurane pretreatment in rats with focal cerebral ischemia and the underlying molecular mechanism

2012 ◽  
Vol 12 (1) ◽  
pp. 675-683 ◽  
Author(s):  
ZHIBIN XIAO ◽  
PENGCHENG REN ◽  
YANG CHAO ◽  
QIANYUN WANG ◽  
JIANKE KUAI ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Molecular Mechanism ◽  
Focal Cerebral Ischemia ◽  
Protective Role

scholarly journals The protective role of verbenalin in rat model of focal cerebral ischemia reperfusion

2018 ◽  
Vol 25 (6) ◽  
pp. 1170-1177 ◽  
Author(s):  
Lihua Cao ◽  
Mingsan Miao ◽  
Jingyi Qiao ◽  
Ming Bai ◽  
Ruiqi Li
Keyword(s):  
Cerebral Ischemia ◽  
Rat Model ◽  
Focal Cerebral Ischemia ◽  
Ischemia Reperfusion ◽  
Protective Role ◽  
Cerebral Ischemia Reperfusion

Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice

Neuroscience ◽  
2009 ◽  
Vol 163 (1) ◽  
pp. 296-307 ◽  
Author(s):  
M. Liu ◽  
N. Eguchi ◽  
Y. Yamasaki ◽  
Y. Urade ◽  
N. Hattori ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Protective Role ◽  
Transient Focal Cerebral Ischemia ◽  
Prostaglandin D Synthase

scholarly journals Differential role of SIRT1/MAPK pathway during cerebral ischemia in rats and humans

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sireesh Kumar Teertam ◽  
Phanithi Prakash Babu
Keyword(s):  
Cerebral Ischemia ◽  
Caspase 3 ◽  
Mapk Pathway ◽  
Protective Role ◽  
Akt Signaling ◽  
Sirtuin 1 ◽  
Neurological Dysfunction ◽  
Dependent Manner ◽  
Erk Mapk

AbstractCerebral ischemia (CI) is a severe cause of neurological dysfunction and mortality. Sirtuin-1 (Silent information regulator family protein 1, SIRT1), an oxidized nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase, plays an important role in protection against several neurodegenerative disorders. The present study aims to investigate the protective role of SIRT1 after CI in experimental young and aged rats and humans. Also, the study examines the possible regulatory mechanisms of neuronal death in CI settings. Immunoblotting and immunohistochemistry were used to evaluate changes in the expression of SIRT1, JNK/ERK/MAPK/AKT signaling, and pro-apoptotic caspase-3 in experimental rats and CI patients. The study findings demonstrated that, in aged experimental rats, SIRT1 activation positively influenced JNK and ERK phosphorylation and modulated neuronal survival in AKT-dependent manner. Further, the protection conferred by SIRT1 was effectively reversed by JNK inhibition and increased pro-apoptotic caspase-3 expression. In young experimental rats, SIRT1 activation decreased the phosphorylation of stress-induced JNK, ERK, caspase-3, and increased the phosphorylation of AKT after CI. Inhibition of SIRT1 reversed the protective effect of resveratrol. More importantly, in human patients, SIRT1 expression, phosphorylation of JNK/ERK/MAPK/AKT signaling and caspase-3 were up-regulated. In conclusion, SIRT1 could possibly be involved in the modulation of JNK/ERK/MAPK/AKT signaling pathway in experimental rats and humans after CI.

scholarly journals The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice

Neuroscience ◽  
2013 ◽  
Vol 244 ◽  
pp. 16-30 ◽  
Author(s):  
W.-L. Li ◽  
S.P. Yu ◽  
D. Chen ◽  
S.S. Yu ◽  
Y.-J. Jiang ◽  
...  
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Regulatory Role

scholarly journals Retraction notice to “The role of ASIC1a in neuroprotection elicited by quercetin in focal cerebral ischemia” [Brain Res. Vol. 1383 (2011) 289–299]

2022 ◽  
Vol 1775 ◽  
pp. 147729
Author(s):  
Anand Kumar Pandey ◽  
Puja Panwar Hazari ◽  
Ranjana Patnaik ◽  
Anil Kumar Mishra
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Retraction Notice

scholarly journals Dual Role of Fcγ Receptor in Transient Focal Cerebral Ischemia in Mice

Stroke ◽  
2004 ◽  
Vol 35 (4) ◽  
pp. 958-963 ◽  
Author(s):  
Miki Komine-Kobayashi ◽  
Nei Chou ◽  
Hideki Mochizuki ◽  
Atsuhito Nakao ◽  
Yoshikuni Mizuno ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Dual Role ◽  
Fcγ Receptor ◽  
Transient Focal Cerebral Ischemia
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