scholarly journals Lateral Growth Limitation of Corneal Fibrils and Their Lamellar Stacking Depend on Covalent Collagen Cross-linking by Transglutaminase-2 and Lysyl Oxidases, Respectively

2013 ◽  
Vol 289 (2) ◽  
pp. 921-929 ◽  
Author(s):  
Lei Wang ◽  
Philipp C. Uhlig ◽  
Eric F. Eikenberry ◽  
Horst Robenek ◽  
Peter Bruckner ◽  
...  
Keyword(s):  
Transglutaminase 2 ◽  
Cross Linking ◽  
Lateral Growth ◽  
Growth Limitation ◽  
Lysyl Oxidases ◽  
Collagen Cross Linking

scholarly journals Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Marwa Kamel ◽  
Mohamed Wagih ◽  
Gokhan S. Kilic ◽  
Concepcion R. Diaz-Arrastia ◽  
Mohamed A. Baraka ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Cross Linking ◽  
Ki 67 ◽  
Subsequent Formation ◽  
Lysyl Oxidases ◽  
Cross Links ◽  
Collagen Cross Linking

The role of the extracellular matrix (ECM) in uterine fibroids (UF) has recently been appreciated. Overhydroxylation of lysine residues and the subsequent formation of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) cross-links underlie the ECM stiffness and profoundly affect tumor progression. The aim of the current study was to investigate the relationship between ECM of UF, collagen and collagen cross-linking enzymes [lysyl hydroxylases (LH) and lysyl oxidases (LOX)], and the development and progression of UF. Our results indicated that hydroxyl lysine (Hyl) and HP cross-links are significantly higher in UF compared to the normal myometrial tissues accompanied by increased expression of LH (LH2b) and LOX. Also, increased resistance to matrix metalloproteinases (MMP) proteolytic degradation activity was observed. Furthermore, the extent of collagen cross-links was positively correlated with the expression of myofibroblast marker (α-SMA), growth-promoting markers (PCNA; pERK1/2;FAKpY397; Ki-67; and Cyclin D1), and the size of UF. In conclusion, our study defines the role of overhydroxylation of collagen and collagen cross-linking enzymes in modulating UF cell proliferation, differentiation, and resistance to MMP. These effects can establish microenvironment conducive for UF progression and thus represent potential target treatment options of UF.

Dermal Collagen Stabilization by Polyphenols and Spray Drying as an Encapsulation Strategy

2018 ◽  
Vol 18 (14) ◽  
pp. 1242-1251 ◽  
Author(s):  
Carolina Anazco ◽  
Armando Rojas ◽  
Ileana Gonzalez ◽  
Maite A. Castro ◽  
Paz Robert ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Spray Drying ◽  
Scientific Evidence ◽  
Cross Linking ◽  
Lysyl Oxidases ◽  
Mammalian Tissues ◽  
Dermal Collagen ◽  
The Impact ◽  
Amino Oxidase ◽  
Collagen Cross Linking

Collagen, the most abundant component in mammalian tissues, has a crucial impact at skin level. Both promotion and maintenance of cross-linked collagen at the skin are critical to sustain the functionality and appearance of that tissue. Lysyl oxidases, also known as LOX enzymes, are the major collagen cross-linking enzymes that play a pivotal role in homeostasis. This minireview summarizes evidence that describes an amino oxidase-like activity, which could be attributed to polyphenols, or where polyphenols could be required. We also discuss some available collagen formulations and the scientific evidence that describes the impact on dermal extracellular matrix. In addition, information about encapsulation strategies to carry polyphenols, and some examples are also provided.

Sorbinil prevents diabetes-induced increases in vascular permeability but does not alter collagen cross-linking

Diabetes ◽  
1985 ◽  
Vol 34 (7) ◽  
pp. 703-705 ◽  
Author(s):  
J. R. Williamson ◽  
K. Chang ◽  
E. Rowold ◽  
J. Marvel ◽  
M. Tomlinson ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Cross Linking ◽  
Collagen Cross Linking
Sign in / Sign up

Export Citation Format

Share Document