scholarly journals NF-κB and Enhancer-binding CREB Protein Scaffolded by CREB-binding Protein (CBP)/p300 Proteins Regulate CD59 Protein Expression to Protect Cells from Complement Attack

2013 ◽  
Vol 289 (5) ◽  
pp. 2711-2724 ◽  
Author(s):  
Yiqun Du ◽  
Xiaoyan Teng ◽  
Na Wang ◽  
Xin Zhang ◽  
Jianfeng Chen ◽  
...  
Keyword(s):  
Protein Expression ◽  
Binding Protein ◽  
Creb Binding Protein ◽  
Creb Protein

scholarly journals Alcohol Exposure Decreases CREB Binding Protein Expression and Histone Acetylation in the Developing Cerebellum

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e19351 ◽  
Author(s):  
Weixiang Guo ◽  
Erin L. Crossey ◽  
Li Zhang ◽  
Stefano Zucca ◽  
Olivia L. George ◽  
...  
Keyword(s):  
Protein Expression ◽  
Histone Acetylation ◽  
Binding Protein ◽  
Alcohol Exposure ◽  
Creb Binding Protein ◽  
Developing Cerebellum

scholarly journals Influence of Diallyl disulphide on Hepatic Gluconeogenesis suppression by CREB Binding protein phosphorylation

2019 ◽  
Vol 10 (2) ◽  
pp. 1327-1331 ◽  
Author(s):  
Prashanthkumar Goudappala ◽  
Ethirajan Sukumar ◽  
Kashinath RT
Keyword(s):  
Liver Tissue ◽  
Binding Protein ◽  
Liver Weight ◽  
Wistar Rat ◽  
Diabetic Rats ◽  
The Body ◽  
Diallyl Disulfide ◽  
Creb Binding Protein ◽  
Creb Protein ◽  
Diabetic Status

Diabetes is an important human ailment affecting many lives in different countries. Diallyl disulfide (DADS), the antidiabetic compound found in garlic, acts as a therapeutic agent in diabetes mellitus condition. This research aimed to investigate the role of DADS on the gluconeogenic mechanism in the liver tissue and the potential involvement of CREB in glucose homeostasis in a Wistar rat model. The alteration in the body weight, liver weight and glycogen content in diabetic rats were prevented by this therapeutic compound: the cAMP-responsive element-binding protein (CREB), an important transcriptional regulator of the gluconeogenic mechanism. The glucose uptake potential was studied by the expression of CREB protein in DADS treated diabetic rats using the western blotting technique. A high level of hepatic CREB protein expression was noted in diabetic status in the chronic hyperglycemic model which was reversed by DADS. The antihyperglycemic effect of DADS was almost similar to that of known antidiabetic drug metformin. The therapeutic action of DADS on diabetic status is due to the control of the glycemic imbalance in liver tissue.

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