scholarly journals An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels

2015 ◽  
Vol 290 (27) ◽  
pp. 16619-16632 ◽  
Author(s):  
Mingxuan Xu ◽  
Edward C. Cooper
Keyword(s):  
Protein Kinase ◽  
Potassium Channels ◽  
Protein Kinase Ck2 ◽  
Voltage Gated ◽  
Ankyrin G ◽  
Kinase Ck2

scholarly journals Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G

2008 ◽  
Vol 183 (6) ◽  
pp. 1101-1114 ◽  
Author(s):  
Aline Bréchet ◽  
Marie-Pierre Fache ◽  
Anna Brachet ◽  
Géraldine Ferracci ◽  
Agnés Baude ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Sodium Channel ◽  
Sodium Channels ◽  
Protein Kinase Ck2 ◽  
Binding Motif ◽  
Nodes Of Ranvier ◽  
Ankyrin G ◽  
Axonal Initial Segment ◽  
Kinase Ck2

In neurons, generation and propagation of action potentials requires the precise accumulation of sodium channels at the axonal initial segment (AIS) and in the nodes of Ranvier through ankyrin G scaffolding. We found that the ankyrin-binding motif of Nav1.2 that determines channel concentration at the AIS depends on a glutamate residue (E1111), but also on several serine residues (S1112, S1124, and S1126). We showed that phosphorylation of these residues by protein kinase CK2 (CK2) regulates Nav channel interaction with ankyrins. Furthermore, we observed that CK2 is highly enriched at the AIS and the nodes of Ranvier in vivo. An ion channel chimera containing the Nav1.2 ankyrin-binding motif perturbed endogenous sodium channel accumulation at the AIS, whereas phosphorylation-deficient chimeras did not. Finally, inhibition of CK2 activity reduced sodium channel accumulation at the AIS of neurons. In conclusion, CK2 contributes to sodium channel organization by regulating their interaction with ankyrin G.

scholarly journals The catalytic subunit of protein kinase CK2 phosphorylates in vitro the movement protein of Tomato mosaic virus

2003 ◽  
Vol 84 (2) ◽  
pp. 497-505 ◽  
Author(s):  
Yasuhiko Matsushita ◽  
Mayumi Ohshima ◽  
Kuniaki Yoshioka ◽  
Masamichi Nishiguchi ◽  
Hiroshi Nyunoya
Keyword(s):  
Protein Kinase ◽  
Mosaic Virus ◽  
Protein Kinase Ck2 ◽  
Movement Protein ◽  
Catalytic Subunit ◽  
Tomato Mosaic Virus ◽  
Kinase Ck2

Yeast surviving factor Svf1 as a new interacting partner, regulator and in vitro substrate of protein kinase CK2

2008 ◽  
Vol 312 (1-2) ◽  
pp. 61-69 ◽  
Author(s):  
Maciej Masłyk ◽  
Elżbieta Kochanowicz ◽  
Rafał Zieliński ◽  
Konrad Kubiński ◽  
Ulf Hellman ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Kinase Ck2

scholarly journals Protein kinase CK2: evidence for a protein kinase CK2β subunit fraction, devoid of the catalytic CK2α subunit, in mouse brain and testicles

FEBS Letters ◽  
1999 ◽  
Vol 462 (3) ◽  
pp. 353-357 ◽  
Author(s):  
Barbara Guerra ◽  
Stefan Siemer ◽  
Brigitte Boldyreff ◽  
Olaf-Georg Issinger
Keyword(s):  
Protein Kinase ◽  
Mouse Brain ◽  
Protein Kinase Ck2 ◽  
Catalytic Ck2α Subunit ◽  
Kinase Ck2
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