scholarly journals Cellular Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Cleaves C3b, an Essential Component of the Complement System

2004 ◽  
Vol 279 (45) ◽  
pp. 46551-46557 ◽  
Author(s):  
Dmitri V. Rozanov ◽  
Alexei Y. Savinov ◽  
Vladislav S. Golubkov ◽  
Tatiana I. Postnova ◽  
Albert Remacle ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Complement System ◽  
Cellular Membrane ◽  
Essential Component ◽  
Membrane Type ◽  
The Complement System

Interference with the Complement System by Tumor Cell Membrane Type-1 Matrix Metalloproteinase Plays a Significant Role in Promoting Metastasis in Mice

2006 ◽  
Vol 66 (12) ◽  
pp. 6258-6263 ◽  
Author(s):  
Dmitri V. Rozanov ◽  
Alexei Y. Savinov ◽  
Vladislav S. Golubkov ◽  
Stephen Tomlinson ◽  
Alex Y. Strongin
Keyword(s):  
Cell Membrane ◽  
Matrix Metalloproteinase ◽  
Tumor Cell ◽  
Significant Role ◽  
Complement System ◽  
Tumor Cell Membrane ◽  
Membrane Type ◽  
The Complement System

scholarly journals Non-proteolytic, Receptor/Ligand Interactions Associate Cellular Membrane Type-1 Matrix Metalloproteinase with the Complement Component C1q

2004 ◽  
Vol 279 (48) ◽  
pp. 50321-50328 ◽  
Author(s):  
Dmitri V. Rozanov ◽  
Sergey Sikora ◽  
Adam Godzik ◽  
Tatiana I. Postnova ◽  
Vladislav Golubkov ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Cellular Membrane ◽  
Complement Component ◽  
Receptor Ligand ◽  
Ligand Interactions ◽  
Membrane Type

scholarly journals O-Glycosylation Regulates Autolysis of Cellular Membrane Type-1 Matrix Metalloproteinase (MT1-MMP)

2006 ◽  
Vol 281 (25) ◽  
pp. 16897-16905 ◽  
Author(s):  
Albert G. Remacle ◽  
Alexei V. Chekanov ◽  
Vladislav S. Golubkov ◽  
Alexei Y. Savinov ◽  
Dmitri V. Rozanov ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Cellular Membrane ◽  
Membrane Type

scholarly journals Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing

2005 ◽  
Vol 280 (28) ◽  
pp. 26160-26168 ◽  
Author(s):  
Pamela Osenkowski ◽  
Samy O. Meroueh ◽  
Dumitru Pavel ◽  
Shahriar Mobashery ◽  
Rafael Fridman
Keyword(s):  
Matrix Metalloproteinase ◽  
Hinge Region ◽  
Membrane Type

4-Methylumbelliferone induces the expression of membrane type 1-matrix metalloproteinase in cultured human skin fibroblasts

2002 ◽  
Vol 298 (5) ◽  
pp. 646-650 ◽  
Author(s):  
Toshiya Nakamura ◽  
Takashi Ishikawa ◽  
Naoki Nanashima ◽  
Tomisato Miura ◽  
Hiroyuki Nozaka ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Membrane Type

scholarly journals Piezo1 mediates angiogenesis through activation of MT1-MMP signaling

2019 ◽  
Vol 316 (1) ◽  
pp. C92-C103 ◽  
Author(s):  
Hojin Kang ◽  
Zhigang Hong ◽  
Ming Zhong ◽  
Jennifer Klomp ◽  
Kayla J. Bayless ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Sprouting Angiogenesis ◽  
Sphingosine 1 Phosphate ◽  
Wall Shear ◽  
Membrane Type

Angiogenesis is initiated in response to a variety of external cues, including mechanical and biochemical stimuli; however, the underlying signaling mechanisms remain unclear. Here, we investigated the proangiogenic role of the endothelial mechanosensor Piezo1. Genetic deletion and pharmacological inhibition of Piezo1 reduced endothelial sprouting and lumen formation induced by wall shear stress and proangiogenic mediator sphingosine 1-phosphate, whereas Piezo1 activation by selective Piezo1 activator Yoda1 enhanced sprouting angiogenesis. Similarly to wall shear stress, sphingosine 1-phosphate functioned by activating the Ca2+ gating function of Piezo1, which in turn signaled the activation of the matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase during sprouting angiogenesis. Studies in mice in which Piezo1 was conditionally deleted in endothelial cells demonstrated the requisite role of sphingosine 1-phosphate-dependent activation of Piezo1 in mediating angiogenesis in vivo. These results taken together suggest that both mechanical and biochemical stimuli trigger Piezo1-mediated Ca2+ influx and thereby activate matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase and synergistically facilitate sprouting angiogenesis.

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