Immunocytochemical studies of cell differentiation during rat salivary gland development

Recombination of the epithelium and mesenchyme between quail anterior submaxillary gland (elongating type) and quail anterior lingual or mouse submaxillary gland (branching type) was effected in vitro to clarify whether the elongating morphogenesis was directed by the epithelial or the mesenchymal component. Quail anterior submaxillary epithelium recombined with quail anterior lingual or mouse submaxillary mesenchyme came to branch. Conversely, quail anterior lingual or 12-day mouse submaxillary epithelium recombined with quail anterior submaxillary mesenchyme came to elongate, though the mesenchyme was less effective with 13-day mouse submaxillary epithelium. These results suggest that the elongating or branching morphogenesis of quail salivary glands is controlled by the mesenchyme.

Download Full-text

Analysis of the mechanism in salivary gland development using gene database

Journal of Oral Biosciences ◽

10.1016/j.job.2018.09.001 ◽

2018 ◽

Vol 60 (4) ◽

pp. 83-86 ◽

Cited By ~ 1

Author(s):

Takayoshi Sakai ◽

Hitomi Ono Minagi ◽

Aya Obana-Koshino ◽

Manabu Sakai

Keyword(s):

Salivary Gland ◽

Gene Database ◽

Gland Development

Download Full-text

Morphology and cytochemistry of the Golgi apparatus of rat salivary gland acinar cells

American Journal of Anatomy ◽

10.1002/aja.1001300203 ◽

1971 ◽

Vol 130 (2) ◽

pp. 141-157 ◽

Cited By ~ 42

Author(s):

Arthur R. Hand

Keyword(s):

Salivary Gland ◽

Golgi Apparatus ◽

Acinar Cells ◽

Rat Salivary Gland

Download Full-text

Radiation Produces Irreversible Chronic Dysfunction in the Submandibular Glands of the Rat

The Open Dentistry Journal ◽

10.2174/1874210601206010008 ◽

2012 ◽

Vol 6 (1) ◽

pp. 8-13 ◽

Cited By ~ 8

Author(s):

C De la Cal ◽

J Fernández-Solari ◽

CE Mohn ◽

JP Prestifilippo ◽

A Pugnaloni ◽

...

Keyword(s):

Single Dose ◽

Salivary Gland ◽

Ionizing Radiation ◽

Salivary Secretion ◽

Maximal Response ◽

Chronic Effect ◽

Post Irradiation ◽

Gland Function ◽

High Doses ◽

Rat Salivary Gland

The exposure to high doses of ionizing radiation during radiotherapy results in severe morphological and functional alterations of the salivary glands, such as xerostomia. In the present study we investigated the chronic effect of a single radiation dose of 15 Gray (Gy) limited to head and neck on rat salivary gland function (salivary secretion and gland mass) and histology. Results indicate that norepinephrine (NE)-induced salivary secretion was reduced significantly at 30, 90, 180 and 365 days after the administration of a single dose of 15 Gy of ionizing radiation compared to non-irradiated animals. The maximal secretory response was reduced by 33% at 30 and 90 days post irradiation. Interestingly, a new fall in the salivary response to NE was observed at 180 days and was maintained at 365 days post irradiation, showing a 75% reduction in the maximal response. The functional fall of the salivary secretion observed at 180 days post irradiation was not only associated with a reduction of gland mass but also to an alteration of the epithelial architecture exhibiting a changed proportion of ducts and acini, loss of eosinophilic secretor granular material, and glandular vacuolization and fibrosis. On the basis of the presented results, we conclude that ionizing radiation produces irreversible and progressive alterations of submandibular gland (SMG) function and morphology that leads to a severe salivary hypo-function.

Download Full-text