Cutaneous Amelanotic Melanoma Metastasis and Dermatofibromas Showing a Dotted Vascular Pattern

Albino patients are at great risk for developing cutaneous neoplasms, including melanomas. In this paper we describe the dermatoscopic findings of nevi in two patients with oculocutaneous albinism type Ia (OCA-Ia) highlighting that they manifest a vascular pattern similar to that described for amelanotic melanoma. We propose managing these patients with dermoscopy, using the comparative approach, digital follow up (DFU), and reflectance confocal microscopy as a complementary tool for difficult cases.

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Dermoscopy of a non-pigmented eccrine poroma

Journal of Surgical Dermatology ◽

10.18282/jsd.v1.i3.55 ◽

2016 ◽

Vol 1 (3) ◽

Author(s):

Maria Clara De Diego ◽

Julieta Ruiz Beguerie

Keyword(s):

Amelanotic Melanoma ◽

Skin Tumors ◽

Vascular Pattern ◽

Clinical Appearance ◽

Lower Back ◽

Adnexal Tumor ◽

Cherry Blossom ◽

Vascular Structures ◽

Slow Growing ◽

Eccrine Poroma

<p>Eccrine poroma is a benign adnexal tumor arising from cells of the outer layer of the acrosyringium and upper dermal eccrine duct. It generally appears as a solitary, slow growing, sessile, pink-to-red and well-circumscribed papule, plaque or nodule. It is usually located on the palms and soles but it may also develop on other locations. Its clinical appearance can resemble other types of tumors such as hypo- or amelanotic melanoma. Dermoscopy has improved the evaluation of skin tumors. In the case of eccrine poroma, there are some studies that have described its dermoscopic findings. These mainly focus on its vascular structures. We present an 82-year-old patient who developed a 2×3-cm eccrine poroma on his lower back. Dermoscopy demonstrated the presence of a polymorphous vascular pattern displaying mostly linear looped (irregular hairpin-like) and “leaf-flower-like” vessels (“cherry-blossom” and “chalice-like”), with some resembling “cactus-like” structures. Only a few linear coiled (glomerular) and linear helical (corkscrew) vessels were observed. Some of these vascular structures were surrounded by a whitish-to-pink halo. Moreover, some pink structureless areas were present. We highlight the finding of the “leaf-flower-like” vessels, as these are vascular structures that have not been described in other types of skin tumors.</p>

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A cystic amelanotic melanoma metastasis to the brain: case report

Neurocirugía ◽

10.1016/s1130-1473(08)70225-2 ◽

2008 ◽

Vol 19 (4) ◽

pp. 365-367 ◽

Cited By ~ 1

Author(s):

B. Cemil ◽

H. Emmez ◽

N. Oztanır ◽

F. Dogulu ◽

N. Tokgoz

Keyword(s):

Case Report ◽

Amelanotic Melanoma ◽

Melanoma Metastasis ◽

The Brain

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Amelanotic Metastatic Gastric Malignant Melanoma: A Case Report

10.21203/rs.3.rs-127891/v1 ◽

2020 ◽

Author(s):

Min Min ◽

Zhang Daya ◽

Zhang Guanjun ◽

Wang Zhanbo ◽

mingyang Li

Keyword(s):

Malignant Melanoma ◽

Clinical Manifestations ◽

Amelanotic Melanoma ◽

Pathological Examination ◽

Positive Staining ◽

Melanoma Metastasis ◽

S 100 ◽

Cutaneous Form ◽

Tumor Metastases ◽

Melanoma Patients

Abstract BackgroundMelanoma is a cutaneous form of disease with an increasing incidence since 1970s, especially in western countries, accounting for nearly 75% of the death related to skin cancer. Clinical outcome varies a lot among different subtypes, and highest recurrence and mortality were observed within the type with distal metastasis. Furthermore, high incidence of gastrointestinal (GI) metastasis of malignant melanoma is frequently misdiagnosed due to lack of specific clinical manifestations. Amelanotic melanoma metastasis, especially the gastrointestinal metastasis, was rarely observed in clinical practice, accounting for only about 2% of all metastatic cases.Case presentationIn the present study, we report a 36-year-old male patient with gastric cancer, who was diagnosed as amelanotic melanoma by Immunohistochemical (IHC) staining, demonstrating positive staining for melanoma markers including Melan A, S-100, Hmb45 and CD79a.ConclusionsIn conclusion, for the colorless tumor metastases found during gastroscopy in melanoma patients, detailed pathological examination should be carried out in combination with previous medical history to determine the nature of the tumor and treatment regime.

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Amelanotic metastatic cutaneous melanoma

Anais Brasileiros de Dermatologia ◽

10.1590/abd1806-4841.20132206 ◽

2013 ◽

Vol 88 (6) ◽

pp. 989-991 ◽

Cited By ~ 5

Author(s):

Marcela Sena Teixeira Mendes ◽

Mariana Carvalho Costa ◽

Ciro Martins Gomes ◽

Lisley Calixto de Araújo ◽

Gustavo Henrique Soares Takano

Keyword(s):

Sensitivity And Specificity ◽

Cutaneous Melanoma ◽

Amelanotic Melanoma ◽

Vascular Pattern ◽

Melanocytic Lesions

Dermatoscopy of melanocytic lesions has guided the decision of when or not to biopsy a lesion. The use of this tool has increased clinical examination's sensitivity and specificity in 89% and 96% respectively. However, dermatoscopic evaluation of amelanotic or hypomelanotic melanomas, as well as metastases, can be difficult. There is still no standardization for the analysis of these pathologies, which relies mostly on their vascular pattern. We describe the dermatoscopy of acral metastatic amelanotic melanoma.

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Diagnostic Value of Electron Microscopy in Soft Tissue Tumors

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100068096 ◽

1970 ◽

Vol 28 ◽

pp. 220-221

Author(s):

Gerald Fine ◽

Azorides R. Morales

Keyword(s):

Cardiac Myxoma ◽

Osteogenic Sarcoma ◽

Diagnostic Value ◽

Soft Tissue Tumors ◽

Amelanotic Melanoma ◽

Growth Patterns ◽

Light Microscopic Level ◽

Mesenchymal Tumors ◽

Good Agreement

For years the separation of carcinoma and sarcoma and the subclassification of sarcomas has been based on the appearance of the tumor cells and their microscopic growth pattern and information derived from certain histochemical and special stains. Although this method of study has produced good agreement among pathologists in the separation of carcinoma from sarcoma, it has given less uniform results in the subclassification of sarcomas. There remain examples of neoplasms of different histogenesis, the classification of which is questionable because of similar cytologic and growth patterns at the light microscopic level; i.e. amelanotic melanoma versus carcinoma and occasionally sarcoma, sarcomas with an epithelial pattern of growth simulating carcinoma, histologically similar mesenchymal tumors of different histogenesis (histiocytoma versus rhabdomyosarcoma, lytic osteogenic sarcoma versus rhabdomyosarcoma), and myxomatous mesenchymal tumors of diverse histogenesis (myxoid rhabdo and liposarcomas, cardiac myxoma, myxoid neurofibroma, etc.)

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Ultrastructural observations on the in vitro cytoadherence of Plasmodium falciparum infected red blood cells

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100162132 ◽

1990 ◽

Vol 48 (3) ◽

pp. 914-915

Author(s):

D.J.P. Ferguson ◽

A.R. Berendt ◽

J. Tansey ◽

K. Marsh ◽

C.I. Newbold

Keyword(s):

Plasmodium Falciparum ◽

Red Blood Cells ◽

Blood Cells ◽

Umbilical Vein ◽

Cell Types ◽

Amelanotic Melanoma ◽

Cytoplasmic Process ◽

Umbilical Vein Endothelial Cells

In human malaria, the most serious clinical manifestation is cerebral malaria (CM) due to infection with Plasmodium falciparum. The pathology of CM is thought to relate to the fact that red blood cells containing mature forms of the parasite (PRBC) cytoadhere or sequester to post capillary venules of various tissues including the brain. This in vivo phenomenon has been studied in vitro by examining the cytoadherence of PRBCs to various cell types and purified proteins. To date, three Ijiost receptor molecules have been identified; CD36, ICAM-1 and thrombospondin. The specific changes in the PRBC membrane which mediate cytoadherence are less well understood, but they include the sub-membranous deposition of electron-dense material resulting in surface deformations called knobs. Knobs were thought to be essential for cytoadherence, lput recent work has shown that certain knob-negative (K-) lines can cytoadhere. In the present study, we have used electron microscopy to re-examine the interactions between K+ PRBCs and both C32 amelanotic melanoma cells and human umbilical vein endothelial cells (HUVEC).We confirm previous data demonstrating that C32 cells possess numerous microvilli which adhere to the PRBC, mainly via the knobs (Fig. 1). In contrast, the HUVEC were relatively smooth and the PRBCs appeared partially flattened onto the cell surface (Fig. 2). Furthermore, many of the PRBCs exhibited an invagination of the limiting membrane in the attachment zone, often containing a cytoplasmic process from the endothelial cell (Fig. 2).

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