Open Heart Surgery Using Total Body Perfusion

1959 ◽  
Vol 25 (2) ◽  
pp. 156-163
Author(s):  
George Stirling ◽  
Richard A. DeWall ◽  
Herbert E. Warden ◽  
Richard L. Varco ◽  
C. Walton Lillehei
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Total Body

Open-heart Surgery for Repair of Congenital Defects

PEDIATRICS ◽  
1959 ◽  
Vol 24 (1) ◽  
pp. 22-22
Keyword(s):  
Heart Surgery ◽  
Surgical Repair ◽  
Open Heart Surgery ◽  
The Body ◽  
Congenital Defects ◽  
Open Heart ◽  
General Reader ◽  
Total Body ◽  
Considerable Body

Anyone anxious to know more about developments in the rapidly-expanding field of surgical repair of congenital defects of the heart by open-heart techniques will find this paper instructive. The various types of apparatus which have been used to maintain the circulation and oxygenation of blood outside the body, leaving the heart free for surgical repair, are described. The physiologic changes during total-body perfusion and the means taken to insure homeostasis during the procedure are discussed. The author gives a brief description of his experience in the repair of congenital defects of the heart with the various techniques. A considerable body of interesting information is provided in a succinct and clear fashion for the general reader.

The Hemostatic Mechanism after Open-Heart Surgery

1978 ◽  
Vol 39 (02) ◽  
pp. 474-487 ◽  
Author(s):  
E R Cole ◽  
F Bachmann ◽  
C A Curry ◽  
D Roby
Keyword(s):  
Extracorporeal Circulation ◽  
Heart Surgery ◽  
Polyacrylamide Gel Electrophoresis ◽  
Open Heart Surgery ◽  
Coagulation System ◽  
Open Heart ◽  
Time Activity ◽  
Post Surgery ◽  
Plasma Fractions ◽  
The Mean

SummaryA prospective study in 13 patients undergoing open-heart surgery with extracorporeal circulation revealed a marked decrease of the mean one-stage prothrombin time activity from 88% to 54% (p <0.005) but lesser decreases of factors I, II, V, VII and X. This apparent discrepancy was due to the appearance of an inhibitor of the extrinsic coagulation system, termed PEC (Protein after Extracorporeal Circulation). The mean plasma PEC level rose from 0.05 U/ml pre-surgery to 0.65 U/ml post-surgery (p <0.0005), and was accompanied by the appearance of additional proteins as evidenced by disc polyacrylamide gel electrophoresis of plasma fractions (p <0.0005). The observed increases of PEC, appearance of abnormal protein bands and concomitant increases of LDH and SGOT suggest that the release of an inhibitor of the coagulation system (similar or identical to PIVKA) may be due to hypoxic liver damage during extracorporeal circulation.

Blood Coagulation Studies and Extracorporeal Circulation in Man

1967 ◽  
Vol 18 (03/04) ◽  
pp. 634-646 ◽  
Author(s):  
N Thurnherr
Keyword(s):  
Blood Coagulation ◽  
Extracorporeal Circulation ◽  
Blood Clotting ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Fibrinolytic System ◽  
Open Heart ◽  
Clotting Factors ◽  
Blood Clotting Factors

SummaryBlood clotting investigations have been executed in 25 patients who have undergone open heart surgery with extracorporeal circulation. A description of alterations in the activity of blood clotting factors, the fibrinolytic system, prothrombin consumption and platelets during several phases of the operation is given.

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