Curcumin and Weight Loss: Does It Work?

Obesity is a global health problem needing urgent research. Synthetic anti-obesity drugs show side effects and variable effectiveness. Thus, there is a tendency to use natural compounds for the management of obesity. There is a considerable body of knowledge, supported by rigorous experimental data, that natural polyphenols, including curcumin, can be an effective and safer alternative for managing obesity. Curcumin is a is an important compound present in Curcuma longa L. rhizome. It is a lipophilic molecule that rapidly permeates cell membrane. Curcumin has been used as a pharmacological traditional medicinal agent in Ayurvedic medicine for ∼6000 years. This plant metabolite doubtless effectiveness has been reported through increasingly detailed in vitro, in vivo and clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes have been remarkably highlighted. This review documents the status of research on anti-obesity mechanisms and evaluates the effectiveness of curcumin for management of obesity. It summarizes different mechanisms of anti-obesity action, associated with the enzymes, energy expenditure, adipocyte differentiation, lipid metabolism, gut microbiota and anti-inflammatory potential of curcumin. However, there is still a need for systematic and targeted clinical studies before curcumin can be used as the mainstream therapy for managing obesity.

Discussion of Issues Related to Language Assessment Literacy in Second Signed and Spoken Languages

This chapter is a joint discussion of key items related to language assessment literacy related to signed and spoken language assessment that were discussed in Chapters 11.1 and 11.2, and the implications that these issues might have on the other field. It is clear that language assessment literacy (LAL) in the context of signed languages—(S)LAL by the authors—is still in a very nascent form. Although in the field of spoken language assessment there is a tendency to discuss LAL as being a “new” development and recent scholarship suggests that issues and constructs remain undertheorized, there is a considerable body of literature on LAL oriented toward spoken language (as surveyed in the Chapter 11.1), to the extent that LAL is now a core area of research and scholarship in the field. This is in sharp contrast with the paucity addressing LAL in the context of signed languages. This chapter is the result of a collaborative process during which the two sets of authors read each other’s chapters and responded to a set of guided questions. The result is the synthesis of this dialogic process.

The Secrets of Alternative Autophagy

For many years, it was thought that ATG5 and ATG7 played a pivotal role in autophagy, and that the knockdown of one of these genes would result in its inhibition. However, cells with ATG5 or ATG7 depletion still generate autophagic vacuoles with mainly trans-Golgi-originated isolation membranes and do not die. This indicates that autophagy can occur via ATG5/ATG7-independent alternative autophagy. Its molecular mechanism differs from that of the canonical pathway, including inter alia the phosphorylation of ULK1, and lack of LC3 modifications. As the alternative autophagy pathway has only recently been described, little is known of its precise role; however, a considerable body of evidence suggests that alternative autophagy participates in mitochondrion removal. This review summarizes the latest progress made in research on alternative autophagy and describes its possible molecular mechanism, roles and methods of detection, and possible modulators. There is a need for further research focused on types of autophagy, as this can elucidate the functioning of various cell types and the pathogenesis of human and animal diseases.

One, No One, and One Hundred Thousand

Despite a considerable body of literature on Italian ethnoregionalist parties, scholars of nationalism and regionalism have overlooked southernist parties. This article aims to fill this lacuna by examining Italian southernist parties’ identity and electoral performance from 1945 to 2020. Firstly, it investigates southernist parties according to ideological positioning, autonomist or secessionist nature, and territorial area of origin. Then, by relying on official data, it explores the parties’ electoral performance in national, European, and regional elections. The main findings of the study show that, since the end of World War II, Italian southernist parties: a) have been characterized by a more autonomist rather than secessionist nature; b) have followed the typical patterns of the catch-all party; c) have performed better in regional elections. This article provides preliminary information on southernist parties, paving the way for further research on such political formations.

The Danish Cartoons, Charlie Hebdo and the culture wars: satiric limits in comparative national and transnational perspectives

A considerable body of academic literature has lauded political satirists as rebellious defenders of democracy and free speech against an establishment. Although satire is not always rebellious, this reputation of satirists and of satire may itself be the object of partisan capture. In this article, it is the object of capture by right-wing populists. In that respect, satire and the meta-discourse about satire can be used like any political rhetoric in gathering like-minded allies, claiming standards, and fighting opponents. With the Danish cartoons crisis of 2005-2006 and the Charlie Hebdo massacre of 2015, proponents of culture wars rhetoric added satire to their list of Western cultural legacies that needed defence against Islamic terrorism as well as left authoritarian elites who suppressed free speech through political correctness. They constructed simplistic global political dichotomies about satire, free speech, and civilisation and lifted events out of local contexts in a process of global framing. The culture war rhetoric was absolutist in support of free speech and satire on the international level. But the national level reveals the hortatory and partisan side to this rhetoric and the complexities that belie the absolutist stand. Nations are the arenas where struggles over free speech and political humour are played out.

Psychopharmacological Perspectives and Diagnosis of Substance Use Disorder

A considerable body of research has accumulated over several decades and altered the current understanding of substance use and its effects on the brain. This knowledge has improved the perception of the disease of addiction and has opened the door to new ways of thinking about diagnosis, prevention, and treatment of substance use disorders. The purpose of the current chapter is to briefly outline and summarize the major psychopharmacological framework underlying substance use disorder (SUD) and the factors that involve in the transformation of some people from recreational use or misuse of alcohol or drugs to SUD. The chapter explains the overall neurocircuitry theories of the addiction cycle: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. It briefly discusses how psychoactive substances produce changes in brain functioning that facilitate the development of addiction and contribute to craving which eventually leads to relapse. The chapter also deals with similarities and differences among various classes of addictive substances in their effects on the brain and behavior and briefly describes the main risk factors that involve SUD. Finally, an attempt is made to briefly discuss the major DSM 5 based behavioral criteria that involve SUD, corresponding to the most abused substances worldwide.

Alexander Samokhvalov's picture frames : tradition and innovation

In recent years, two contradictory trends related to the study and display of picture frames have emerged in Russian museums. On the one hand, these works have at last caught the attention of scholars leading to publications on the evolution of art framing in Russia. However, the framing of paintings in museums is still not carried out on the basis of conducted research. In the light of a rapidly developing frame market, art historians and art critics have been increasingly replacing historical frames with massproduced ones, while disregarding historical reliability and authenticity of the frames, or the need to follow the author’s conception. Meanwhile, it is known that artists of different eras, as a rule, paid great attention to the selection of picture frames, with some among them, like A. N. Samokhvalov, creating their own. Thus, the purpose of the article is to examine the frames made by Samokhvalov, as well as to draw attention to the question of the author’s original picture framing. Samokhvalov’s frames are characterized by their unique design, which greatly affects the perception of the painting. Despite the fact that there exists a considerable body of art historical studies dedicated to the artist’s work, none of the researchers took notice of the problem of the picture framing. The article is the first to provide a scholarly introduction of designs and drawings of Samokhvalov’s frames, as well as works of art created on their basis. The artist’s frames from the collections of various museums have been attributed according to a comparative analysis. Likewise, traditional and innovative features in the works of Samokhvalov have been revealed as a result of stylistic assessment and comparison of frames produced by the artist with picture frames of the 17th – 20th centuries. The article illuminates the unexplored facet of the artist’s work presenting it in a new light. The research will not only allow to further preserve the unique frames of Samokhvalov in Russian museums, but also exhibit his works in accordance with the author’s intention.

A novel framework for integrating social media as cooperative learning tool in higher education’s classrooms

Despite the considerable body of literature on social media (SM)’s use as formal educational tools within universities, little has been done to provide a comprehensive adoption framework for SM as cooperative learning (CL) instruments. Nonetheless, the pedagogical arguments for SM’s use in HE have theory support. This paper proposes an original SM integration framework based on CL methods within higher education (HE). An integrative review of relevant literature followed by a thematic review of six peer-reviewed empirical research and a thorough examination of relevant SM adoption models are conducted to identify commonalties and themes. In total, six themes were identified and incorporated as major components in the proposed framework. To the best of our knowledge, no previous research has proposed a framework that incorporates CL principles to support an effective SM integration process in HE. This paper proposes a novel integration framework which is a theoretically driven pedagogical guide for incorporating SM in HE’s classrooms. It provides valuable insights on SM’s use in education and forms the basis for future quantitative and qualitative (framework-testing) research in this area of study.

How Personal Experience Affects Perception of and Decisions Related to Climate Change: A Psychological View

The proportion of the world’s population exposed to above-average monthly temperatures has been rising consistently in recent decades and will continue to grow. This and similar trends make it more likely that people will personally experience extreme weather events and seasonal changes related to climate change. A question that follows from this is to what extent experiences may influence climate-related beliefs, attitudes, and the willingness to act. Although research is being done to examine the effects of such experiences, many of these studies have two important shortcomings. First, they propose effects of experiences but remain unclear on the psychological processes that underlie those effects. Second, if they do make assumptions about psychological processes, they do not typically corroborate them with empirical evidence. In other words, a considerable body of research in this field rests on relatively unfounded intuitions. To advance the theoretical understanding of how experiences of climate change could affect the motivation to act on climate change, we introduce a conceptual framework that organizes insights from psychology along three clusters of processes: 1) noticing and remembering, 2) mental representations, and 3) risk processing and decision-making. Within each of these steps, we identify and explicate psychological processes that could occur when people personally experience climate change, and we formulate theory-based, testable hypotheses. By making assumptions explicit and tying them to findings from basic and applied research from psychology, this paper provides a solid basis for future research and for advancing theory.

Evolution, Biology, and Aggression

There are numerous complementary approaches to the biology of aggression, ranging from genetic to cognitive research. Arguably, the most successful of them have been guided by hypotheses derived from evolutionary theory. In contrast to the view that human aggression is symptomatic of psychological impairment, social disorganization, or both, evolution-minded hypotheses typically begin from the premise that aggression has been designed by natural selection to serve one or more adaptive functions, and that the mechanisms involved can be sensitive to cues of reproductive consequences in the social environment. Specifically, anatomical, physiological, and psychological adaptations for aggression are expected to evolve when they help individuals secure resources and matings for themselves and for their genealogical kin. From a theoretical perspective, contexts of predation, sexual competition, and sexual conflict are especially likely to foment aggression. A considerable body of research on aggression in nonhuman animals reinforces the adaptationist position, and central findings of this viewpoint—such as differential risk of violence according to sex and kinship—are closely mirrored in humans. Although many features of human aggression are likely the result of adaptations designed to yield these very features, others are more plausibly understood as byproducts of adaptations designed for different purposes. In either case, evolutionary approaches can help to identify the mechanisms underlying aggression and thereby provide ways to reduce its impact.