The Folate Conjugase Activity of the Intestinal Mucosa in Celiac Disease

1974 ◽  
Vol 9 (3) ◽  
pp. 255-259
Author(s):  
M. Jägerstad ◽  
K. Lindstrand ◽  
Å. Nordén ◽  
A.-K. Westesson ◽  
T. Lindberg
Keyword(s):  
Celiac Disease ◽  
Intestinal Mucosa

scholarly journals Contribution of Infectious Agents to the Development of Celiac Disease

2021 ◽  
Vol 9 (3) ◽  
pp. 547
Author(s):  
Daniel Sánchez ◽  
Iva Hoffmanová ◽  
Adéla Szczepanková ◽  
Věra Hábová ◽  
Helena Tlaskalová-Hogenová
Keyword(s):  
Celiac Disease ◽  
Intestinal Mucosa ◽  
Wheat Gluten ◽  
Small Intestinal Mucosa ◽  
Beneficial Effects ◽  
Immune Mediated ◽  
Healthy State ◽  
Food Antigens ◽  
Small Intestinal ◽  
And Function

The ingestion of wheat gliadin (alcohol-soluble proteins, an integral part of wheat gluten) and related proteins induce, in genetically predisposed individuals, celiac disease (CD), which is characterized by immune-mediated impairment of the small intestinal mucosa. The lifelong omission of gluten and related grain proteins, i.e., a gluten-free diet (GFD), is at present the only therapy for CD. Although a GFD usually reduces CD symptoms, it does not entirely restore the small intestinal mucosa to a fully healthy state. Recently, the participation of microbial components in pathogenetic mechanisms of celiac disease was suggested. The present review provides information on infectious diseases associated with CD and the putative role of infections in CD development. Moreover, the involvement of the microbiota as a factor contributing to pathological changes in the intestine is discussed. Attention is paid to the mechanisms by which microbes and their components affect mucosal immunity, including tolerance to food antigens. Modulation of microbiota composition and function and the potential beneficial effects of probiotics in celiac disease are discussed.

scholarly journals Magnifying endoscopy of the duodenum with dye scattering method in a case with celiac disease

2003 ◽  
Vol 40 (2) ◽  
pp. 110-113 ◽  
Author(s):  
Tetsuo Morishita ◽  
Toshiaki Kamiya ◽  
Hiromasa Ishii
Keyword(s):  
Celiac Disease ◽  
Intestinal Mucosa ◽  
Indigo Carmine ◽  
Duodenal Mucosa ◽  
Magnifying Endoscopy ◽  
Scattering Method ◽  
Small Intestinal Mucosa ◽  
Before And After ◽  
Dye Scattering Method ◽  
Magnifying Endoscope

AIM: To know the more detailed findings of the small intestinal mucosa with the use of a magnifying endoscope and a vital dye, and the efficacy of the both tools. PATIENT AND METHODS: A 54-year old female patient with celiac disease. The duodenal mucosa downward as far as the descending portion was observed with a magnifying endoscope (Olympus GIF HM) before and after spraying the mucosa with 0.1% indigo carmine. RESULTS: The endoscopy clarified the atrophy and edema of each villus, and scattering of the dye revealed shorter villi with the relatively longer villi remaining in islands. CONCLUSION: The combination of magnifying endoscopy and the dye scattering method is useful for closer observation of the intestinal mucosa in celiac diseases.

BETA-GALACTOSIDASE AND BETA-GLUCURONIDASE ACTIVITIES IN INTESTINAL MUCOSA OF INFANTS AND CHILDREN

PEDIATRICS ◽  
1971 ◽  
Vol 47 (4) ◽  
pp. 737-744
Author(s):  
Irena Antonowicz ◽  
Harry Shwachman ◽  
Ishida Sotoo
Keyword(s):  
Celiac Disease ◽  
Intestinal Mucosa ◽  
Lysosomal Enzymes ◽  
Normal Activity ◽  
Acute Stage ◽  
Infants And Children ◽  
Protein Losing Enteropathy ◽  
Per Oral ◽  
Beta Galactosidase ◽  
Duodenal Biopsies

The activity of two galactosidases (lactase and hetero-β-galactosidase) and β-glucuronidase were studied in per oral duodenal biopsies in 50 infants and children. Ten patients served as controls and 40 had nutritional disorders including celiac disease (acute, and in remission), cystic fibrosis (CF), protein losing enteropathy, and some miscellaneous conditions. The values for the 10 control patients expressed in units/gm protein/minute ± S.D. follows: lactase 38.0 ± 13.4, H-β-gal-ase 1.42 ± 0.35., and β-glucuronidase 1.90 ± 0.45. In the acute stage of celiac disease the lactase values were markedly reduced, the H-β-gal-ase normal or slightly reduced, with normal activity for β-glucuronidase. In clinical remission and while still on a gluten-free diet the activity of lactase remained significantly reduced in seven of nine patients even after 2 to 10 years. The lysosomal enzymes H-β-gal-ase and β-glucuronidase were not strikingly affected in patients with CF although four of six patients showed low values for H-β-galactosidase. β-glucuronidase was not affected in a variety of intestinal disorders including those that severely affect the integrity of the intestinal mucosa. In the conditions studied there was no correlation between the activity of the two galactosidases, nor between the two lysosomal enzymes.

scholarly journals Genome-Wide Transcriptomic Analysis of Intestinal Mucosa in Celiac Disease Patients on a Gluten-Free Diet and Postgluten Challenge

2021 ◽  
Vol 11 (1) ◽  
pp. 13-32 ◽  
Author(s):  
Valeriia Dotsenko ◽  
Mikko Oittinen ◽  
Juha Taavela ◽  
Alina Popp ◽  
Markku Peräaho ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Intestinal Mucosa ◽  
Transcriptomic Analysis ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Genome Wide

Diagnostic accuracy and usefulness of intraepithelial lymphocytes immunophenotyping in intestinal mucosa for the diagnosis of celiac disease

2019 ◽  
Vol 493 ◽  
pp. S376
Author(s):  
X. Gabaldó Barrios ◽  
S. Cladellas Núñez ◽  
M. Juanpere Aixalà ◽  
I. Fort Gallifa ◽  
L. Castro Reyes ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Diagnostic Accuracy ◽  
Intestinal Mucosa ◽  
Intraepithelial Lymphocytes

Upregulation of KIR3DL1 gene expression in intestinal mucosa in active celiac disease

2011 ◽  
Vol 72 (8) ◽  
pp. 617-620 ◽  
Author(s):  
Nora Fernandez-Jimenez ◽  
Izortze Santín ◽  
Iñaki Irastorza ◽  
Leticia Plaza-Izurieta ◽  
Ainara Castellanos-Rubio ◽  
...  
Keyword(s):  
Gene Expression ◽  
Celiac Disease ◽  
Intestinal Mucosa

scholarly journals Expression Pattern of Fatty Acid Binding Proteins in Celiac Disease Enteropathy

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Natalia M. Bottasso Arias ◽  
Marina García ◽  
Constanza Bondar ◽  
Luciana Guzman ◽  
Agustina Redondo ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Fatty Acid ◽  
Expression Pattern ◽  
Intestinal Mucosa ◽  
Binding Proteins ◽  
Fatty Acid Binding Proteins ◽  
Small Intestinal Mucosa ◽  
Mrna Levels ◽  
Fatty Acid Binding ◽  
Small Intestinal

Celiac disease (CD) is an immune-mediated enteropathy that develops in genetically susceptible individuals following exposure to dietary gluten. Severe changes at the intestinal mucosa observed in untreated CD patients are linked to changes in the level and in the pattern of expression of different genes. Fully differentiated epithelial cells express two isoforms of fatty acid binding proteins (FABPs): intestinal and liver, IFABP and LFABP, respectively. These proteins bind and transport long chain fatty acids and also have other important biological roles in signaling pathways, particularly those related to PPARγand inflammatory processes. Herein, we analyze the serum levels of IFABP and characterize the expression of both FABPs at protein and mRNA level in small intestinal mucosa in severe enteropathy and normal tissue. As a result, we observed higher levels of circulating IFABP in untreated CD patients compared with controls and patients on gluten-free diet. In duodenal mucosa a differential FABPs expression pattern was observed with a reduction in mRNA levels compared to controls explained by the epithelium loss in severe enteropathy. In conclusion, we report changes in FABPs’ expression pattern in severe enteropathy. Consequently, there might be alterations in lipid metabolism and the inflammatory process in the small intestinal mucosa.

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