Feline Model of Chronic Obstructive Pancreatitis: Effects of Acute Pancreatic Duct Decompression on Blood Flow and Interstitial pH

Background—Autosomal dominant polycystic kidney disease, the most frequent inherited polycystic disease, is a systemic disorder characterised by the development of numerous and bilateral kidney cysts leading to chronic renal failure. Extrarenal cysts are located mainly in the liver but also in various organs including the pancreas. To our knowledge, complications of pancreatic cysts in this disease have never been reported.Patient—The first case of painful chronic obstructive pancreatitis due to a true pancreatic cyst in a patient with autosomal dominant polycystic kidney disease is reported. Abdominal transparietal and endoscopic ultrasonography, computed tomography, and endoscopic retrograde cholangiopancreatography showed a cystic lesion in the body of the pancreas associated with upstream dilatation of the main pancreatic duct. Intraoperative ultrasonography before and after cyst fluid aspiration, and pancreatography and pathological examination of the resected distal pancreas confirmed that both main pancreatic duct enlargement and chronic pancreatitis were caused by a benign cyst.Conclusion—Chronic obstructive pancreatitis should be added to the extrarenal complications of autosomal dominant polycystic kidney disease.

Download Full-text

Compartment syndrome in experimental chronic obstructive pancreatitis: Effect of decompressing the main pancreatic duct

British Journal of Surgery ◽

10.1002/bjs.1800810236 ◽

1994 ◽

Vol 81 (2) ◽

pp. 259-264 ◽

Cited By ~ 96

Author(s):

N. D. Karanjia ◽

A. L. Widdison ◽

F. Leung ◽

C. Alvarez ◽

F. J. Lutrin ◽

...

Keyword(s):

Pancreatic Duct ◽

Compartment Syndrome ◽

Main Pancreatic Duct ◽

Chronic Obstructive ◽

Obstructive Pancreatitis

Download Full-text

Mucinous cystadenoma of pancreatic head with focal malignant alteration in a 52-year old man

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0704204c ◽

2007 ◽

Vol 135 (3-4) ◽

pp. 204-207

Author(s):

Radoje Colovic ◽

Marjan Micev ◽

Vladimir Radak ◽

Nikica Grubor ◽

Mirjana Stojkovic ◽

...

Keyword(s):

Pancreatic Duct ◽

Mucinous Cystadenoma ◽

Pancreatic Head ◽

Postoperative Recovery ◽

The Body ◽

Chronic Obstructive ◽

Obstructive Pancreatitis ◽

Head Of The Pancreas ◽

Malignant Alteration ◽

Mucinous Cystadenomas

Mucinous cystadenomas of the pancreas are rare tumors appearing usually within the body and the tail of the pancreas in a young and middle-aged women. They rarely communicate with the pancreatic duct and occasionally may become malignant. The authors present a patient with a number of rare features. In a 52 year-old male, we did a radical pylorus-preserving cephalic duodenopancreatectomy for a mucinous cystadenoma within the head of the pancreas, which perforated into the main pancreatic duct causing chronic obstructive pancreatitis having few foci of malignant alteration. The postoperative recovery was uneventful, but three months later the patient died due to exacerbation of the underlying serious heart disease. .

Download Full-text

Chronic Obstructive Pancreatitis as a Delayed Complication of Pancreatic Trauma

HPB Surgery ◽

10.1155/1991/73834 ◽

1991 ◽

Vol 5 (1) ◽

pp. 49-60 ◽

Cited By ~ 18

Author(s):

Edward L. Bradley

Keyword(s):

Chronic Pancreatitis ◽

Pancreatic Duct ◽

Motor Vehicle ◽

Chronic Obstructive ◽

Pancreatic Trauma ◽

Vehicle Accidents ◽

Obstructive Pancreatitis ◽

Delayed Complication ◽

Pancreatic Duct Hypertension ◽

Societal Violence

Increasing surgical experience with the immediate consequences of pancreatic injuries has resulted from parallel growth in the volume of motor vehicle accidents and societal violence. However, few surgeons are aware that complications may be considerably delayed following pancreatic trauma, occurring in some cases months to years after apparent recovery from the original injury. In four patients with blunt pancreatic trauma initially treated by non-operative means, stricture of the main pancreatic duct developed over a period of months as a result of progressive fibrosis at the site of ductal injury. Pancreatic duct hypertension was demonstrated to be present in the obstructed duct, and secondary changes of chronic pancreatitis developed in the obstructed segment of the gland (“upstream” chronic pancreatitis). Seven similar patients with delayed onset of chronic obstructive pancreatitis after pancreatic trauma were found in the literature. Symptoms related to these acquired ductal strictures are most commonly those of abdominal pain and recurrent episodes of acute pancreatitis. Recognition of post-traumatic chronic obstructive pancreatitis principally involves awareness that injuries to the pancreatic duct can produce remote complications. Pancreatoenteric drainage, or resection of the obstructed segment of pancreas, provides prompt and effective relief.

Download Full-text

The Effect of Aminophylline on Cerebral Blood Flow in Patients with Chronic Obstructive Pulmonary Disease

CHEST Journal ◽

10.1378/chest.91.6.874 ◽

1987 ◽

Vol 91 (6) ◽

pp. 874-877 ◽

Cited By ~ 15

Author(s):

David L. Bowton ◽

Peter T. Alford ◽

Byron D. McLees ◽

Donald S. Prough ◽

David A. Stump

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Blood Flow ◽

Cerebral Blood Flow ◽

Pulmonary Disease ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease

Download Full-text

Modeling Cerebral Blood Flow and Ventilation Instability due to CO2

Journal of Applied Physiology ◽

10.1152/japplphysiol.00949.2020 ◽

2021 ◽

Author(s):

Stanley M. Yamashiro ◽

Takahide Kato

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Current Model ◽

Respiratory Control ◽

Breath Hold ◽

Chronic Obstructive ◽

Brain Blood Flow ◽

Linear Interaction ◽

Non Linear ◽

Flow Changes

A minimal model of cerebral blood flow and respiratory control was developed to describe hypocapnic and hypercapnic responses. Important non-linear properties such as cerebral blood flow changes with arterial partial pressure of carbon dioxide (PaCO2) and associated time dependent circulatory time delays were included. It was also necessary to vary cerebral metabolic rate as a function of PaCO2. The cerebral blood flow model was added to a previously developed respiratory control model to simulate central and peripheral controller dynamics for humans. Model validation was based on previously collected data. The variable time delay due to brain blood flow changes in hypercapnia was an important determinant of predicted instability due to non-linear interaction in addition to linear loop gain considerations. Peripheral chemoreceptor gains above a critical level, but within normal limits, was necessary to produce instability. Instability was observed in recovery from hypercapnia and hypocapnia. The 20 sec breath-hold test appears to be a simple test of brain blood flow mediated instability in hypercapnia. Brain blood flow was predicted to play an important role with non-linear properties. There is an important interaction predicted by the current model between central and peripheral control mechanisms related to instability in hypercapnia recovery. Post hyperventilation breathing pattern can also reveal instability tied to brain blood flow. Previous data collected in patients with chronic obstructive lung disease was closely fitted with the current model and instability predicted. Brain vascular volume was proposed as a potential cause of instability despite cerebral autoregulation promoting constant brain flow.

Download Full-text

Comparison of Cerebral Blood Flow after Venesection of Bronchitic Secondary Polycythaemic and Primary Polycythaemic Patients

Scottish Medical Journal ◽

10.1177/003693308302800404 ◽

1983 ◽

Vol 28 (4) ◽

pp. 332-337 ◽

Cited By ~ 5

Author(s):

P. d'A. Semple ◽

G. D. O. Lowe ◽

J. Patterson ◽

G. H. Beastall ◽

J. O. Rowan ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Similar Degree ◽

Chronic Obstructive ◽

Blood Oxygen ◽

Before And After ◽

Obstructive Airways Disease ◽

Flow Improvement ◽

Chronic Obstructive Airways Disease ◽

Symptomatic Benefit

Cerebral blood flow was measured before and after lowering of haematocrit in four patients with primary polycythaemia and in nine with polycythaemia secondary to chronic obstructive airways disease. Cerebral blood flow values in each group were abnormally low to a similar degree at the start of the study and the degree of rise in cerebral blood flow per unit fall in haematocrit after venesection also was similar in each. Oxygen delivery fell despite increased cerebral blood flow and symptomatic benefit was infrequent. In male secondary polycythaemic patients rise in cerebral blood flow was not associated with any improvement in hypothalamo-pituitary-testicular function which we had previously noted to be suppressed in such hypoxic subjects. Our findings suggest viscosity changes rather than alteration in blood oxygen carriage to be responsible for cerebral blood flow improvement. It is concluded that therapeutic venesection in such patients should be applied with caution.

Download Full-text