Assessment of drug–drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase

Xenobiotica ◽  
2018 ◽  
Vol 49 (1) ◽  
pp. 54-70 ◽  
Author(s):  
Zeen Tong ◽  
Rangaraj Narayanan ◽  
Christian Atsriku ◽  
Jim Nissel ◽  
Yan Li ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Potent Inhibitor ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Pbpk Modeling ◽  
Drug Drug Interaction

scholarly journals A Novel PBPK Modeling Approach to Assess Cytochrome P450 Mediated Drug-Drug Interaction Potential of the Cytotoxic Prodrug Evofosfamide

2018 ◽  
Vol 7 (12) ◽  
pp. 829-837 ◽  
Author(s):  
Christian Lüpfert ◽  
Martin Dyroff ◽  
Oliver von Richter ◽  
Dieter Gallemann ◽  
Samer El Bawab ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interaction ◽  
Interaction Potential ◽  
Pbpk Modeling ◽  
Modeling Approach ◽  
Drug Drug Interaction

Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential

2012 ◽  
Vol 30 (3) ◽  
pp. 761-780 ◽  
Author(s):  
Michael Gertz ◽  
Catherine M. Cartwright ◽  
Michael J. Hobbs ◽  
Kathryn E. Kenworthy ◽  
Malcolm Rowland ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Pbpk Modeling ◽  
Efflux Transporters ◽  
Drug Drug Interaction

Disposition and Drug-Drug Interaction Potential of Veliparib (ABT-888), a Novel and Potent Inhibitor of Poly(ADP-ribose) Polymerase

2011 ◽  
Vol 39 (7) ◽  
pp. 1161-1169 ◽  
Author(s):  
Xiaofeng Li ◽  
Juergen Delzer ◽  
Richard Voorman ◽  
Sonia M. de Morais ◽  
Yanbin Lao
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Potent Inhibitor ◽  
Drug Drug Interaction
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