A new Co(II)-coordination polymer: prevention of postpartum hemorrhage by increasing the prothrombin activity

2020 ◽  
Vol 73 (24) ◽  
pp. 3344-3353
Author(s):  
Jing Wang ◽  
Ying Ding ◽  
Yuan-Yuan Jia ◽  
Gui-Yu Zhao
Keyword(s):  
Coordination Polymer ◽  
Postpartum Hemorrhage ◽  
Prothrombin Activity

Substituted imidazole copper(II) complexes: The coordination polymer complex tetrakis N -methylimidazole copper(II) sulfate

2003 ◽  
Vol 56 (8) ◽  
pp. 647-653 ◽  
Author(s):  
Lan Liu ◽  
Stan Duraj ◽  
Phillip E. Fanwick ◽  
Maria T. Andras ◽  
Aloysius F. Hepp
Keyword(s):  
Coordination Polymer ◽  
Polymer Complex

Placental Transfer of Vitamin K1 and Its Implications in Fetal Hemostasis

1988 ◽  
Vol 60 (01) ◽  
pp. 039-043 ◽  
Author(s):  
L Mandelbrot ◽  
M Guillaumont ◽  
M Leclercq ◽  
J J Lefrère ◽  
D Gozin ◽  
...  
Keyword(s):  
Vitamin K ◽  
High Performance ◽  
Ultrasound Guidance ◽  
Placental Transfer ◽  
Vitamin K1 ◽  
Vitamin K Deficiency ◽  
Prothrombin Activity ◽  
Oral Supplementation ◽  
K Deficiency ◽  
The Mean

SummaryVitamin K status was evaluated using coagulation studies and/ or vitamin IQ assays in a total of 53 normal fetuses and 47 neonates. Second trimester fetal blood samples were obtained for prenatal diagnosis under ultrasound guidance. Endogenous vitamin K1 concentrations (determined by high performance liquid chromatography) were substantially lower than maternal levels. The mean maternal-fetal gradient was 14-fold at mid trimester and 18-fold at birth. Despite low vitamin K levels, descarboxy prothrombin, detected by a staphylocoagulase assay, was elevated in only a single fetus and a single neonate.After maternal oral supplementation with vitamin K1, cord vitamin K1 levels were boosted 30-fold at mid trimester and 60 fold at term, demonstrating placental transfer. However, these levels were substantially lower than corresponding supplemented maternal levels. Despite elevated vitamin K1 concentrations, supplemented fetuses and neonates showed no increase in total or coagulant prothrombin activity. These results suggest that the low prothrombin levels found during intrauterine life are not due to vitamin K deficiency.

Adhesive Platelet Count and Blood Coagulability in Myocardial Infarction and Cerebral Thrombosis

1970 ◽  
Vol 24 (03/04) ◽  
pp. 450-460 ◽  
Author(s):  
H Yamazaki ◽  
T Odakura ◽  
K Takeuchi ◽  
T Sano
Keyword(s):  
Myocardial Infarction ◽  
Platelet Count ◽  
Malignant Tumors ◽  
Total Cholesterol Level ◽  
Statistical Significance ◽  
Acute Stage ◽  
Cerebral Thrombosis ◽  
Prothrombin Activity ◽  
Recovery Stage ◽  
Blood Coagulability

SummaryIn 382 patients, aged 21 to 76 years, including 39 healthy volunteers, a platelet count by Olef’s method, an adhesive platelet count by Moolten-Vroman’s method, prothrombin activity due to one-stage prothrombin time and calcium clotting time were measured. In 39 cases of myocardial infarction and 40 cases of cerebral thrombosis, both in acute stage, a marked decrease in the adhesive platelet count and adhesive index and an increase of prothrombin activity were observed with statistical significance compared to the healthy group (P < 0.01). In the recovery stage of myocardial infarction, cerebral thrombosis and other diseases, except for malignant tumors, acute infectious diseases, diabetes mellitus and blood or liver diseases, the above observations were absent or reduced. In the case of thrombosis, a negative correlation was seen between the adhesive platelet count and prothrombin activity (r — —0.238, P < 0.01). There is no correlation between the changes in platelet adhesiveness or blood coagulability and total cholesterol level in serum.

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