Adhesive Platelet Count and Blood Coagulability in Myocardial Infarction and Cerebral Thrombosis

1970 ◽  
Vol 24 (03/04) ◽  
pp. 450-460 ◽  
Author(s):  
H Yamazaki ◽  
T Odakura ◽  
K Takeuchi ◽  
T Sano
Keyword(s):  
Myocardial Infarction ◽  
Platelet Count ◽  
Malignant Tumors ◽  
Total Cholesterol Level ◽  
Statistical Significance ◽  
Acute Stage ◽  
Cerebral Thrombosis ◽  
Prothrombin Activity ◽  
Recovery Stage ◽  
Blood Coagulability

SummaryIn 382 patients, aged 21 to 76 years, including 39 healthy volunteers, a platelet count by Olef’s method, an adhesive platelet count by Moolten-Vroman’s method, prothrombin activity due to one-stage prothrombin time and calcium clotting time were measured. In 39 cases of myocardial infarction and 40 cases of cerebral thrombosis, both in acute stage, a marked decrease in the adhesive platelet count and adhesive index and an increase of prothrombin activity were observed with statistical significance compared to the healthy group (P < 0.01). In the recovery stage of myocardial infarction, cerebral thrombosis and other diseases, except for malignant tumors, acute infectious diseases, diabetes mellitus and blood or liver diseases, the above observations were absent or reduced. In the case of thrombosis, a negative correlation was seen between the adhesive platelet count and prothrombin activity (r — —0.238, P < 0.01). There is no correlation between the changes in platelet adhesiveness or blood coagulability and total cholesterol level in serum.

Platelet Aggregability Measured by SFP Method in Cerebral Thrombosis and Haemorrhage

1975 ◽  
Author(s):  
I. Kobayashi ◽  
H. Yamazaki
Keyword(s):  
Essential Hypertension ◽  
Cerebral Hemorrhage ◽  
Time Course ◽  
Acute Stage ◽  
Cerebral Thrombosis ◽  
Recovery Stage ◽  
Platelet Aggregability ◽  
Significant Difference ◽  
The Difference ◽  
Death Cases

Platelet aggregability of 50 aged healthy people (64.0 ±9.4 yrs., Mean ±SD), 93 essential hypertension (65.6±8.5 yrs.), 166 recovery stage of cerebral thrombosis over 2 months from the onset (62.4 ± 11.8 yrs.) and 74 recovery stage of cerebral hemorrhage (57.4 ±10.0 yrs.) was measured using screen filtration pressure (SFP, Swank, 1961) method. SFP by 3 μM ADP of healthy, hypertension, recovery stage of cerebral hemorrhage and thrombosis were 148.7±53.5, 176.2± 74.4, 189.8±58.3 and 206.3±58.9 mmHg respectively. The differences of the SFP between the healthy and the diseased groups were statistically significant (P < 0.01-0.05). Meanwhile SFP of 9 cerebral thrombosis (66.8±9.5 yrs.) and 18 hemorrhage (66.4 ±10.6 yrs.) was measured during their time course of the diseases from the onset to 180 days. SFP in acute stage of thrombosis showed an increase and it decreased gradually during the time course. On the contrary SFP in acute stage of hemorrhage showed a decrease and it increased gradually. A statistically significant difference was observed between both the groups within 30 days from the onset (P < 0.01 ). SFP in acute stage of hemorrhage showed 95.2 ±17.7 in 9 survival and 1Ö4.0±Ö6.2 mmHg in 9 death cases within 10 days from the onset. The difference of the SFP between survival and death was statistically significant (P < 0.01).

Enhancement of ADP-induced Platelet Aggregation by Adrenaline in Vivo and Its Prevention

1973 ◽  
Vol 29 (02) ◽  
pp. 490-498 ◽  
Author(s):  
Hiroh Yamazaki ◽  
Itsuro Kobayashi ◽  
Tadahiro Sano ◽  
Takio Shimamoto
Keyword(s):  
Platelet Count ◽  
Platelet Aggregation ◽  
Platelet Rich Plasma ◽  
The Other ◽  
Endothelial Surface ◽  
Important Interaction ◽  
Blood Coagulability ◽  
The Difference

SummaryThe authors previously reported a transient decrease in adhesive platelet count and an enhancement of blood coagulability after administration of a small amount of adrenaline (0.1-1 µg per Kg, i. v.) in man and rabbit. In such circumstances, the sensitivity of platelets to aggregation induced by ADP was studied by an optical density method. Five minutes after i. v. injection of 1 µg per Kg of adrenaline in 10 rabbits, intensity of platelet aggregation increased to 115.1 ± 4.9% (mean ± S. E.) by 10∼5 molar, 121.8 ± 7.8% by 3 × 10-6 molar and 129.4 ± 12.8% of the value before the injection by 10”6 molar ADP. The difference was statistically significant (P<0.01-0.05). The above change was not observed in each group of rabbits injected with saline, 1 µg per Kg of 1-noradrenaline or 0.1 and 10 µg per Kg of adrenaline. Also, it was prevented by oral administration of 10 mg per Kg of phenoxybenzamine or propranolol or aspirin or pyridinolcarbamate 3 hours before the challenge. On the other hand, the enhancement of ADP-induced platelet aggregation was not observed in vitro, when 10-5 or 3 × 10-6 molar and 129.4 ± 12.8% of the value before 10∼6 molar ADP was added to citrated platelet rich plasma (CPRP) of rabbit after incubation at 37°C for 30 second with 0.01, 0.1, 1, 10 or 100 µg per ml of adrenaline or noradrenaline. These results suggest an important interaction between endothelial surface and platelets in connection with the enhancement of ADP-induced platelet aggregation by adrenaline in vivo.

Assessment of Admission Time Cell Blood Count (CBC) Parameters in Predicting Post-primary Percutaneous Coronary Intervention TIMI Frame Count in Patients with ST-segment Elevation Myocardial Infarction

2020 ◽  
Vol 20 (3) ◽  
pp. 191-197
Author(s):  
Hossein Vakili ◽  
Isa Khaheshi ◽  
Amirsina Sharifi ◽  
Negin Nickdoost ◽  
Mohammad H. Namazi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Platelet Count ◽  
P Value ◽  
Primary Pci ◽  
Blood Samples ◽  
Timi Frame Count ◽  
Admission Time ◽  
No Reflow ◽  
Corrected Timi Frame Count ◽  
No Reflow Phenomenon

Objectives: In this study, we aimed to assess the value of admission time CBC parameters in predicting post-primary PCI corrected TIMI frame count. Background: Recent years have witnessed a large series of studies evaluating different laboratory variables to predict no-reflow phenomenon following primary PCI (PPCI) in patients with STEMI. However, a general agreement about the most reliable predictor of the no-reflow phenomenon is challenging and also intriguing. Methods: The current study concluded 208 consecutive patients who underwent primary PCI for ST-Elevation Myocardial Infarction (STEMI) from January 2014 to February 2016. Blood samples were obtained after taking ECG. Complete blood samples were collected and analyzed within 5 minutes from sampling. Post-PCI corrected Thrombolysis in Myocardial Infarction (TIMI) frame count was determined by one interventional cardiologist blinded to patients’ clinical data. The correlation between admission time blood parameters and post-primary PCI corrected TIMI frame count in patients with STEMI were assessed. Results: Corrected TIMI frame count was positively correlated with WBC count (R: 0.18, P-value: <0.01), neutrophil count (R: 0.34, P-value: <0.01), and platelet count (R: 0.23, P-value: <0.01) and negatively correlated with lymphocyte count (R: -0.2, P-value: <0.01). Multiple linear regression results demonstrated that corrected TIMI frame count was positively correlated with neutrophil count (P < 0·001) and platelet count (P < 0·001) and negatively correlated with lymphocyte count (p=0.004). Conclusion: High counts of WBC, neutrophil, and platelet and low count of lymphocyte may be predictors of no-reflow in STEMI patients undergoing PPCI. The clinical significance of such predictive parameters becomes clear as we consider the treatment approach in STEMI patients. Appropriate risk stratification leads to better treatment planning and allocation of resources.

Race and Rorschach Signs of Brain Damage in Cerebral Thrombosis

1966 ◽  
Vol 22 (2) ◽  
pp. 655-662 ◽  
Author(s):  
Ray B. Evans ◽  
Jessie Marmorston
Keyword(s):  
Myocardial Infarction ◽  
Brain Damage ◽  
Cerebral Thrombosis ◽  
The Brain ◽  
Item Scale

In an attempt to identify Rorschach signs which would differentiate the brain-damaged regardless of race, a study was made of 225 Caucasian and 127 Negro patients between 40 and 80 yr. of age. There was known brain damage (cerebral thrombosis) in 204 patients, and no known brain damage in 148 patients (myocardial infarction). Each of 31 Rorschach signs of cerebral impairment was studied to determine its power in discriminating Caucasian damaged from nondamaged and Negro damaged from nondamaged patients. A combination of 13 signs was thereby selected in which race did not appear to be a significant factor. The 13-item scale differentiated brain-damaged from nondamaged Caucasian, Negro, and combined Caucasian-Negro groups, all at levels below .001. The 13-item scale correctly classified 71% of the patients, compared with 73% when all 31 signs were used.

scholarly journals Influence of the primary malignant tumor site on the incidence and features of metastatic ovarian tumors

2007 ◽  
Vol 64 (10) ◽  
pp. 691-696 ◽  
Author(s):  
Zorica Stanojevic ◽  
Biljana Djordjevic ◽  
Danijela Zivanovic
Keyword(s):  
Malignant Tumor ◽  
Malignant Tumors ◽  
Statistical Significance ◽  
Menopausal Status ◽  
Ovarian Tumors ◽  
Metastatic Tumors ◽  
Primary Tumors ◽  
Primary Malignant Tumor ◽  
Group A ◽  
Group B

Background/Aim. Ovary is the organ of the female reproductive system most commonly affected by metastases. The aim of the study was to determine the frequency and features of metastatic ovarian tumors (MOT) depending on the site of the primary malignant tumor. Methods. The study group consisted of 488 patients with histopathologically confirmed ovarian cancers treated at the Clinic of Oncology, Clinical Center Nis, in the period from 1 January 1998 to 31 December 2005. MOT were found in 41 patients. Regarding the site of the primary malignant tumor, those with secondary ovarian tumor were divided into two groups: group A - primary malignant tumor involving the genital organs (n = 30) and group B - primary malignant tumor of extragenital origin (n = 11). Results. MOT were confirmed in 8.40% (41/488) of the patients. Secondary ovarian malignancies were the consequence of endometrial carcinoma spreading in 73.17%, breast carcinoma in 19.51%, stomach carcinoma in 4.88% and colon carcinoma in 2.44% of the cases. No significant differences were found between the group A and group B by the factors of age, body mass index, parity and menopausal status. Contrary to the group A, metastatic tumors in the group B patients were more commonly asymptomatic (p < 0.001), bilateral (p < 0.05), with larger ovarian diameter (p < 0.05), associated with ascites (p < 0.001) and abdominal metastases (p < 0.01), all of statistical significance. Conclusions. Metastatic tumors made up 8.40% of ovarian neoplasmas. With non-genital primary tumors, secondary ovarian deposits were frequently asymptomatic, bilateral, associated with larger ovarian diameter, ascites and abdominal metastatic deposits, compared to malignant tumors of genital origin.

scholarly journals Gender-Related Differences of Cardiac Troponin-I Levels in Patients with Acute Myocardial Infarction at Time of Acute Chest Pain

2021 ◽  
pp. 199-205
Author(s):  
Mahir Abdulkadhum Khudhair Alzughaibi ◽  
Ammar Waheeb Obeiad ◽  
Nassar Abdalaema Abdalhadi Mera ◽  
Mohammed Sadeq Hamzah Al-Ruwaiee
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Chest Pain ◽  
Troponin I ◽  
Statistical Significance ◽  
Acute Chest Pain ◽  
Blood Analysis ◽  
P Value ◽  
Cross Sectional ◽  
Time Of Admission

Background: Cardiac Troponins-I (CTNI) are myoregulatory polypeptides that control the actin-myosin interface, considered specific to cardiomyocytes. Age and sex variances in the extent of CTNI levels have arisen a recent debatable emphasis. Existing revisions do not display a reliable clinical power of sex-specific CTNI 99th centiles, which actually might mirror procedural aspects. Nevertheless, from a biochemical viewpoint, the trends of sex-specific CTNI 99th centiles seem sensible for the ruling-in of acute myocardial infarction AMI. Vulnerable females may be missed when applying the male sex-specific threshold. This study aimed to determine whether gender differences in CTNI exist in patients with AMI presented with chest pain. Methodology: The study was a cross-sectional, single-center, included 236-patients with AMI diagnosis by cardiologists at Merjan teaching hospital during the period from April to July 2020 from patients attending the hospital for cardiac consultation complaining of acute chest pain suggestive of AMI. Blood analysis had initiated at the time of admission included serum creatinine, blood urea, R/FBS, WBCs, PCV, and serum CTNI. A p-value below 0.05 specifies statistical significance. All statistical bioanalyses had performed by IBM-SPSS, version-25 for Windows. Results: The mean age of participants was 67.5 years, the men were dominant 76.2%. The incidence of DM and hypertension were significantly high and 24.5% of the patients were current smokers. Biochemical serum analysis revealed mean creatinine, urea, sugar, and STI values were 79.8±4.2 mmol/l, 15.9±1.7 mmol/l, 10.9±0.9 mmol/l, and 7.9±0.6 ng/ml separately. Both hypertension and smoking were significantly (p-0.001) more among males compared to the females, which is not the case for the prevalence of DM. The males were heavier significantly than females (p-0.001). Almost, there was no impact of gender on most of the other study variables other than serum TNI levels, which were significantly higher among the males (p-0.001). Conclusion: In patients with AMI presented with acute chest pain, the routine of CTNI in the diagnosis of AMI is based on the patient's gender. The application of gender-dependent cutoff levels for CTNI analyses appears to be highly suggested.

Effect of Donor Variables on Platelet Yield Among Donor Undergoing Plateletpheresis at Transfusion Medicine Department, Dhaka Medical College Hospital (Experience of 350 Procedures)

2021 ◽  
Vol 28 (2) ◽  
pp. 179-183
Author(s):  
Shanaz Karim ◽  
Md Mazharul Hoque ◽  
Ehteshamul Hoque ◽  
Kashfia Islam ◽  
ABM Al Mamun
Keyword(s):  
Platelet Count ◽  
Statistical Significance ◽  
Haemoglobin Concentration ◽  
Transfusion Medicine ◽  
College Hospital ◽  
Platelet Recovery ◽  
Medicine Department ◽  
Medical College ◽  
Donor Factors

Background: The platelet transfusions help in prevention of bleeding related complications and thus prevents morbidity and mortality in thrombocytopenic patients. Platelet transfusion plays an important role in the treatment of haematological, oncological, surgical, and transplant patients. Platelets are transfused by two methods i) by fractionation of whole blood and ii) by platelet apheresis. Over the last decade there has been a trend towards the use of SDPs rather than pooled random donor platelets in thrombocytopenic patients. Optimization of platelet yield is an emerging issue to identify factors which may help in selecting donors to obtain higher platelet yields in shorter time and consequently better clinical outcome. Objective: The quality of single donor platelets (SDP) in terms of yield influences the platelet recovery in the recipient. The aim was to identify the SDP donor factors that influence platelet yield. Methods: The study was undertaken at transfusion medicine department, DMCH from 1st January 2017 to 31st December 2017. The study included 350 plateletpheresis procedures. All procedures were performed according to manufacturer’s manual and standard operating procedure. Results: During the period of study, 350 platelet pheresis donors were studied. All of the donors were male. Platelet yield showed high statistical significance with pre donation platelet count and its indices. (p=0.000). Statistical significant negative correlation was seen between pre donation Hb concentration and the platelet yield. (p =0.005). No statistical significance was seen height (p=0.933), weight (p=0.760) of donor on platelet yield. Conclusion: Platelet recovery in the patient is influenced by the transfused dose of platelets, which in turn is dependent on the quality of the platelet product in terms of yield. Various donor factors such as pre donation platelet count and haemoglobin concentration may affect platelet yield. J Dhaka Medical College, Vol. 28, No.2, October, 2019, Page 179-183

Platelet production regulation and dynamics of platelets functional activity in patients with ST segment elevation at myocardial infarction treated with double antiplatelet therapy

2019 ◽  
Author(s):  
Л.И. Малинова ◽  
П.В. Долотовская ◽  
Н.Ф. Пучиньян ◽  
Н.В. Фурман ◽  
Т.П. Денисова
Keyword(s):  
Myocardial Infarction ◽  
Platelet Count ◽  
Platelet Aggregation ◽  
Antiplatelet Therapy ◽  
Functional Activity ◽  
Relative Width ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment ◽  
D Dimer

Введение. В ряде исследований продемонстрирована ассоциация доли молодых тромбоцитов с риском повторных тромботических событий у больных с острым коронарным синдром; однако взаимосвязь интенсивности тромбоцитогенеза и динамики функциональной активности тромбоцитов на фоне двойной антитромбоцитарной терапии (ДАТ) при острой необратимой ишемии и некробиозе миокарда остается малоизученной. Цель исследования: оценить особенности тромбоцитопоэза в сопоставлении с параметрами функциональной активности тромбоцитов на фоне ДАТ у больных инфарктом миокарда с подъемом сегмента ST (ИМпST). Материал и методы. У больных ИМпST (мужчины, n = 101) при поступлении, на 2-й и 7-й день госпитализации иммуноферментным методом определяли уровни тромбопоэтина, фактора стромальных клеток 1, тромбопоэтинового рецептора и Д-димера. Агрегационную активность тромбоцитов, секрецию плотных гранул, количество тромбоцитов, средний объем тромбоцита, относительную ширину распределения тромбоцитов по размеру оценивали при поступлении и на 7-е сутки. Результаты. В течение 7 дней на фоне ДАТ у 69,3% больных ИМпST происходил рост количества тромбоцитов — 270 [227; 279] × 109/л vs. 300 [265; 304] × 109/л (p = 0,007), что сопровождалось снижением коллаген-индуцированной агрегации тромбоцитов — 9,0 [7,0; 16,0] Ом vs. 6,5 [3,5; 8,5] Ом (p = 0,047). Направление и величина изменения количества тромбоцитов коррелировали с уровнем тромбопоэтина при поступлении (R = 0,656; p = 0,039). У пациентов с ИМпST с ростом количества тромбоцитов происходило увеличение уровня Д-димера — 302 [96; 812] нг/мл vs. 126 [94; 325] нг/мл (р = 0,048). Определены граничные условия относительной устойчивости системы тромбоцитогеза у больных ИМпST на фоне ДАТ: уровень тромбопоэтина — 180–310 пг/мл. Заключение. Полученные данные свидетельствуют о модификации регуляции тромбоцитогенеза у больных ИМпST на фоне ДАТ, однако клиническое значение этого нуждается в дополнительном изучении. Introduction. Several studies have demonstrated the association of young platelets amount with the risk of rethrombotic events in patients with acute coronary syndrome, but the relationship between intensity of thrombocytogenesis and the dynamics of platelet functional activity under double antiplatelet therapy (DAT) in acute irreversible ischemia and myocardium necrobiosis remains poorly understood. Aim: to assess the characteristics of thrombocytopoiesis in comparison with the parameters of functional platelets activity in patients with myocardial infarction with ST segment elevation (STеMI) and treated with DAT. Materials and methods. Thrombopoietin, stromal cell derived factor 1, thrombopoietin receptor and D-dimer levels were determined by the enzyme immunoassay method in 101 male patients with STеMI on admission, on the 2nd and 7th days of hospitalization. Platelet aggregation activity, dense granule secretion, platelet count, average platelet volume and relative width of platelet size distribution were assessed on admission and on 7th day. Results. Within 7 days under DAT in 69.3% of STеMI patients platelet count increased — 270 [227; 279] × 109/L vs. 300 [265, 304] × 109/L (p = 0.007) that was accompanied by reduction of collagen-induced platelet aggregation — 9.0 [7.0; 16.0] Om vs. 6.5 [3.5; 8.5] Om (p = 0.047). The direction and magnitude of platelet count change correlated with thrombopoietin level on admission (R = 0.656; p = 0.039). Together with platelet count rising in STеMI patients D-dimer level increased — 302 [96; 812] ng/ml vs. 126 [94; 325] ng/ml (p = 0.048). We identifi ed boundary conditions of the relative thrombocytogenesis stability in STеMI patients under DAT: thrombopoietin level — 180–310 pg/ml. Conclusion. Received data suggest a modifi cation of thrombocytogenesis regulation in STеMI patients treated with DAT; however, the clinical signifi cance of this observation requires further investigation.

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