Maternal and umbilical cord blood level of macrophage migration inhibitory factor and insulin like growth factor in Sudanese women with preeclampsia

2018 ◽  
Vol 39 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Selma Mahmoud ◽  
Hind Nasri ◽  
Abubakr M. Nasr ◽  
Ishag Adam
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Blood Level ◽  
Umbilical Cord Blood ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Insulin Like Growth Factor

Insulin-like growth factor-II: a novel autocrine growth factor modulating the apoptosis and maturation of umbilical cord blood erythroid progenitors

2008 ◽  
Vol 36 (4) ◽  
pp. 401-411 ◽  
Author(s):  
Taro Nagatomo ◽  
Koichiro Muta ◽  
Shouichi Ohga ◽  
Masayuki Ochiai ◽  
Koichi Ohshima ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Insulin Like Growth Factor ◽  
Erythroid Progenitors ◽  
Autocrine Growth ◽  
Autocrine Growth Factor ◽  
Factor Ii

scholarly journals Impact of a Low-Glucose Peritoneal Dialysis Regimen on Fibrosis and Inflammation Biomarkers

2015 ◽  
Vol 35 (2) ◽  
pp. 147-158 ◽  
Author(s):  
Susan Yung ◽  
Sing Leung Lui ◽  
Chris K.F. Ng ◽  
Andrew Yim ◽  
Maggie K.M. Ma ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Growth Factor ◽  
Adhesion Molecule ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Membrane Integrity ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Vascular Endothelial ◽  
Low Glucose

BackgroundThe impact of a low-glucose peritoneal dialysis (PD) regimen on biomarkers of peritoneal inflammation, fibrosis and membrane integrity remains to be investigated.MethodsIn a randomized, prospective study, 80 incident PD patients received either a low-glucose regimen comprising Physioneal (P), Extraneal (E) and Nutrineal (N) (Baxter Healthcare Corporation, Deerfield, IL, USA) (PEN group), or Dianeal (control group) for 12 months, after which both groups continued with Dianeal dialysis for 6 months. Serum and dialysate levels of vascular endothelial growth factor (VEGF), decorin, hepatocyte growth factor (HGF), interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), hyaluronan (HA), adiponectin, solubleintracellular adhesion molecule (s-ICAM), vascular cell adhesion molecule-1 (VCAM-1) and P-selectin, and dialysate cancer antigen 125 (CA125), were measured after 12 and 18 months. This paper focuses on results after 12 months, when patients in the PEN group changed to glucose-based PD fluid (PDF).ResultsAt the end of 12 months, effluent dialysate levels of CA125, decorin, HGF, IL-6, adiponectin and adhesion molecules were significantly higher in the PEN group compared to controls, but all decreased after patients switched to glucose-based PDF. Macrophage migration inhibitory factor level was lower in the PEN group but increased after changing to glucose-based PDF and was similar to controls at 18 months. Serum adiponectin level was higher in the PEN group at 12 months, but was similar in the 2 groups at 18 months. Body weight, residual renal function, ultrafiltration volume and total Kt/V did not differ between both groups. Dialysate-to-plasma creatinine ratio at 4 h was higher in the PEN group at 12 months and remained so after switching to glucose-based PDF.ConclusionChanges in the biomarkers suggest that the PEN PD regimen may be associated with better preservation of peritoneal membrane integrity and reduced systemic vascular endothelial injury.

GLYCOSYLATED FIBRONECTIN AND INHIBIN ARE LOWER AND ANTI-MÜLLERIAN HORMONE IS HIGHER IN UMBILICAL CORD BLOOD WHEN MOTHERS HAVE PREECLAMPSIA

2020 ◽  
Vol 26 (3) ◽  
pp. 318-327
Author(s):  
Bridget DiPrisco ◽  
Ajay Kumar ◽  
Bhanu Kalra ◽  
Gopal V. Savjani ◽  
Zoe Michael ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Immunosorbent Assay ◽  
Plasma Protein ◽  
Umbilical Cord Blood ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Levels ◽  
Insulin Like Growth Factor ◽  
Tertiary Teaching

Objective: Preeclampsia is a common disorder of pregnancy, causing significant morbidity and mortality for mothers and infants. Several molecules, including glycosylated fibronectin (GlyFn), the inhibin-related proteins, anti-müllerian hormone (AMH), and the insulin-like growth factor axis, are altered in maternal plasma in the setting of preeclampsia; however, these molecules have not been previously measured in cord blood of infants born to mothers with preeclampsia, which may represent changes in fetal physiology. We evaluated potential biomarkers of preeclampsia in umbilical cord blood to fill the gap in knowledge. Methods: This is a case-control study of 196 neonates born at a tertiary teaching hospital in Boston from 2010–2017. Forty-nine neonates born to mothers with preeclampsia were matched 1:3 by gestational age, sex, and birth weight z-score with 147 controls. Eleven analytes were measured in cord blood by enzyme-linked immunosorbent assay. Binary logistic regression analyses were performed to evaluate associations between preeclampsia and analytes. Results: Mean cord blood levels of GlyFn and total inhibin were significantly lower in neonates born to mothers with preeclampsia compared to controls, and AMH levels were significantly higher in males born to mothers with preeclampsia than male controls. Associations remained significant after controlling for maternal and neonatal characteristics. Conclusion: Cord blood levels of GlyFn and inhibin are decreased and AMH (male) levels are increased in infants of preeclamptic mothers, which is opposite the pattern these biomarkers show in serum of mothers with preeclampsia. These molecules may be important in the pathophysiology and long-term effects of preeclampsia on the developing fetus. Abbreviations: AMH = anti-müllerian hormone; ELISA = enzyme-linked immunosorbent assay; GlyFn = glycosylated fibronectin; IGF = insulin-like growth factor; IGFBP5 = insulin-like growth factor binding protein 5; LOD = limit of detection; PAPP-A = pregnancy-associated plasma protein A; PAPP-A2 = pregnancy-associated plasma protein A2

Age and sex-specific differences in interleukin 4, interferon gamma, macrophage migration inhibitory factor, and vascular endothelial growth factor levels in the tears of healthy subjects

2021 ◽  
pp. 112067212110640
Author(s):  
Dominika Mravec Bencúrová ◽  
Šárka Mandíková ◽  
Pavlína Daňková
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Interleukin 4 ◽  
Macrophage Migration ◽  
Vascular Endothelial ◽  
Biological Factors ◽  
Endothelial Growth Factor

Objective To investigate the physiological profile of pro-inflammatory and anti-inflammatory cytokines in tears produced by epithelial cells under the effect of endogenous and exogenous biological factors. Knowing the physiological cytokine profile in tears with its biological characteristics including sex- and age-specific effects is fundamental when tears are analyzed for diagnostic or prognostic purposes in eye diseases. Methods Tear samples were collected from right eye of 45 healthy volunteers (24 males, 21 females) by 5 μl microcapillary tube. Cytokines interleukin 1β, interleukin 10, interleukin 4, interferon gamma, macrophage migration inhibitory factor, and vascular endothelial growth factor were quantified by multiplex Bio-Plex system. Results The production of macrophage migration inhibitory factor cytokine by epithelial cells on the ocular surface is higher in males compared to females ( p = 0.05); actually, most of female tear samples present with undetectable macrophage migration inhibitory factor levels. Our results show the negative correlations between the age and concentrations of interleukin 4 ( p < 0.01) and interferon gamma ( p < 0.01) in tears, respectively, and positive associations of vascular endothelial growth factor levels with the age above 45 years ( p < 0.05). Conclusions Data in this study indicate that age and sex may affect the physiological levels of cytokines in tears. Consequently, the impacts of biological factors need to be recognized and taken into consideration before the levels of cytokines in patients’ tears are analyzed for medical reasons. Concentrations of interleukin 1β and interleukin 10 cytokines, however, are very low in healthy tears and do not seem to be influenced by studied biological factors; therefore, they meet the requirements for analytes suitable for medical diagnostic and prognostic purposes.

Differential effects of low birthweight and intrauterine growth restriction on umbilical cord blood insulin-like growth factor concentrations

2015 ◽  
Vol 83 (5) ◽  
pp. 739-745 ◽  
Author(s):  
Anja Tzschoppe ◽  
Christina Riedel ◽  
Rüdiger von Kries ◽  
Ellen Struwe ◽  
Wolfgang Rascher ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Intrauterine Growth Restriction ◽  
Low Birthweight ◽  
Growth Restriction ◽  
Insulin Like Growth Factor ◽  
Blood Insulin ◽  
Intrauterine Growth

STUDIES OF INSULIN-LIKE GROWTH FACTOR -I AND -II BY SPECIFIC RADIOLIGAND ASSAYS IN UMBILICAL CORD BLOOD

1983 ◽  
Vol 19 (3) ◽  
pp. 405-413 ◽  
Author(s):  
P. D. GLUCKMAN ◽  
J. J. JOHNSON-BARRETT ◽  
J. H. BUTLER ◽  
B. W. EDGAR ◽  
T. R. GUNN
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Racial variation in umbilical cord blood sex steroid hormones and the insulin-like growth factor axis in African-American and white female neonates

2012 ◽  
Vol 23 (3) ◽  
pp. 445-454 ◽  
Author(s):  
Tanya Agurs-Collins ◽  
Sabine Rohrmann ◽  
Catherine Sutcliffe ◽  
Jessica L. Bienstock ◽  
Deborah Monsegue ◽  
...  
Keyword(s):  
African American ◽  
Growth Factor ◽  
Cord Blood ◽  
Steroid Hormones ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
White Female ◽  
Insulin Like Growth Factor
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