Digital disruption brought by the Fourth Industrial Revolution (4IR) technologies has a major impact on cultures, strategies, structures, and processes of organizations. This change also requires a shift in leadership mindset to respond to opportunities, challenges, and dilemmas in the implementation of Industry 4.0 (I4.0). Moreover, effective leadership in the digital age requires developing a wide variety of core components of leadership. Therefore, improving the essential characteristics, capabilities, and skills of leaders plays a pivotal role in accelerating the path to success in the I4.0. In this regard, this chapter provides an in-depth discussion on leadership aspects of I4.0. The purpose of this chapter is to first present emerging leadership styles in I4.0. The chapter also explores what leadership roles have become more relevant in the age of I4.0 and what kind of fundamental leadership skills they need to possess in order to succeed.