Evaluation of the Reliability and Validity of the Alzheimer’s Disease-Related Quality of Life Instrument among Older Adults with Cognitive Impairment in Mainland China

Author(s):  
Kaipeng Wang ◽  
Xiang Gao ◽  
Fei Sun ◽  
Carson M. De Fries ◽  
Sue E. Levkoff
CNS Spectrums ◽  
2004 ◽  
Vol 9 (S5) ◽  
pp. 20-23 ◽  
Author(s):  
Gary W. Small

AbstractThe prevalence of Alzheimer's disease (AD) and dementia continues to rise. However, a significant number of patients are undiagnosed or untreated. Given the complexities of detecting cognitive impairment and the early signs of AD, this review discusses how advances in brain imaging can help assist in improving overall management. Imaging techniques and surrogate markers may provide unique opportunities to diagnose accurately AD in presymptomatic stages with practical consequences for patients, caregivers, and physicians. The possible outcomes for using imaging and surrogate markers as adjuncts to clinical examination and as screening tools for AD, as well as tangible and intangible advantages to early diagnosis and treatment, will be discussed. The specific value of using advanced serial imaging in patients with a genetic disposition to AD will be evaluated. If neurons can be protected from neurodegenerative damage in early stages, this may preserve patient cognition, function, and quality of life, and may confer considerable societal healthcare benefits.


2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Maria I. Andreakou ◽  
Angelos A. Papadopoulos ◽  
Demosthenes B. Panagiotakos ◽  
Dimitris Niakas

Background.Alzheimer’s disease (AD) dementia is a chronic neurodegenerative disorder that results in total cognitive impairment and functional decline. Family members are the most usual caregivers worldwide, resulting in a subsequent degradation of their quality of life.Methods.During November 2013–March 2014 in Athens, Greece, 155 AD patients’ family caregivers’ Health-Related Quality of Life and existence of depressive symptomatology were assessed.Results.A strong negative correlation between the dimensions of HRQoL and the scores of the depression scale was revealed. AD patients’ caregivers have a lower HRQoL almost in all dimensions compared to the Greek urban general population. The caregivers’ social role, the existence of emotional problems, and their mental health status led to this result. Furthermore significantly important differences in caregivers’ total HRQoL and depressive symptomatology were indicated in relation to their gender, hypertension existence, patient care frequency, cohabitation with the patient, disease aggravation, and economic status.Conclusions.Caring for relatives with AD strongly correlates with negative caregivers’ HRQoL scores and adversely affects their depressive symptomatology. This negative correlation is enhanced in the later stages of the disease, in greater frequency of care, through living with a patient, in poor financial status, and with the existence of a chronic illness.


2016 ◽  
Vol 51 (2) ◽  
pp. 545-561 ◽  
Author(s):  
Philipp Heßmann ◽  
Greta Seeberg ◽  
Jens Peter Reese ◽  
Judith Dams ◽  
Erika Baum ◽  
...  

2009 ◽  
Vol 5 (4S_Part_8) ◽  
pp. P236-P237 ◽  
Author(s):  
Daniel L. Murman ◽  
Mary Charlton ◽  
Robin High ◽  
Christopher Leibman ◽  
Trent McLaughlin

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