The Incidence of and Factors Associated with Vitamin D Deficiency in Newly Diagnosed Children with Cancer

Background To investigate the relationship 25-hydroxy vitamin D (25OHD) level among children and in children with type 1 diabetes mellitus (T1DM). Methods A case–control study was conducted to compare the serum 25OHD levels between cases and controls. This study recruited 296 T1DM children (106 newly diagnosed T1DM patients and 190 established T1DM patients), and 295 age- and gender-matched healthy subjects as controls. Results The mean serum 25OHD in T1DM children was 48.69 ± 15.26 nmol/L and in the controls was 57.93 ± 19.03 nmol/L. The mean serum 25OHD in T1DM children was lower than that of controls (P < 0.01). The mean serum 25OHD level (50.42 ± 14.74 nmol/L) in the newly diagnosed T1DM children was higher than that (47.70 ± 15.50 nmol/L) in the established T1DM children but the difference was not statistically significant (P = 0.16). HbA1c values were associated with 25OHD levels in established T1DM children (r = 0.264, P < 0.01), and there was no association between 25OHD and HbA1c in newly diagnosed T1DM children (r = 0.164; P > 0.05). Conclusion Vitamin D deficiency is common in T1DM children, and it should be worthy of attention on the lack of vitamin D in established T1DM children.

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Gender-Specific Factors Associated with Vitamin D Deficiency among Korean Adolescents: Data from the Korean National Health and Nutrition Examination Survey V (2010~2011)

Child Health Nursing Research ◽

10.4094/chnr.2018.24.2.157 ◽

2018 ◽

Vol 24 (2) ◽

pp. 157-165 ◽

Cited By ~ 1

Author(s):

Haeyoung Min ◽

Ari Min

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

National Health ◽

Nutrition Examination Survey ◽

Korean Adolescents ◽

Factors Associated ◽

Health And Nutrition ◽

Specific Factors ◽

Gender Specific

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Sociodemographic and perinatal factors associated with vitamin D deficiency in exclusively breastfeeding infants in North Central Nigeria

Alexandria Journal of Pediatrics ◽

10.4103/ajop.ajop_18_21 ◽

2021 ◽

Vol 34 (2) ◽

pp. 101

Author(s):

BankoleP Kuti ◽

LateefatO Adebiyi ◽

AdebanjoJ Adegbola ◽

Chuma Onuchukwu ◽

OyekuA Oyelami

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Perinatal Factors ◽

North Central ◽

Factors Associated

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Alteration of the Intestinal Microbial Flora and the Serum IL-17 Level in Patients with Graves’ Disease Complicated with Vitamin D Deficiency

International Archives of Allergy and Immunology ◽

10.1159/000518949 ◽

2021 ◽

pp. 1-10

Author(s):

Mengxue Yang ◽

Fei Li ◽

Rui Zhang ◽

Yueyue Wu ◽

Qian Yang ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Intestinal Flora ◽

Graves Disease ◽

Newly Diagnosed ◽

Tsh Receptor Antibody ◽

Differential Species ◽

Intestinal Microbial Flora ◽

Deficiency Group ◽

Case Number

Background: Intestinal flora is associated with Graves’ disease (GD). This study explored the association of serum 25(OH)D with the diversity of the intestinal flora and serum IL-17 in GD patients. Methods: Patients newly diagnosed with GD at 2 centers between 2018 and 2021 were consecutively included. According to their 25(OH)D levels, they were divided into the deficiency group, the insufficiency group, and the sufficiency group. Some patients with vitamin D deficiency or insufficiency were randomly selected and were matched with healthy volunteers (normal control [NC]) in terms of sex, age, and case number. The diversity and differential species of the intestinal flora and serum IL-17 levels were compared. Results: Serum 25(OH)D negatively correlated with serum IL-17, the platelet/lymphocyte ratio, and TSH receptor antibody. The diversity of the intestinal flora decreased in the GD group, with noticeable differences in the composition of the intestinal flora when compared with the NC group. At the phylum level, the GD group exhibited a significantly lower abundance of Firmicutes but a higher abundance of Actinobacteria. At the genus level, the GD group exhibited higher relative abundances of Bifidobacterium, Collinsella, and Pediococcus but lower abundances of Roseburia and Dialister. Conclusions: The changes in the vitamin D level and the composition of the intestinal flora may partially contribute to the development of GD.

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