Prevalence of Hypovitaminosis D and Factors Associated With Vitamin D Deficiency and Morbidity Among HIV-Infected Patients Enrolled in a Large Italian Cohort

Background: Vitamin D deficiency is one of the most common micronutrient deficiency in children worldwide, even in Bangladesh. However, to date, the prevalence of vitamin D deficiency among children of different region of Bangladesh is less reported. Objective: This study was conducted to assess vitamin D status of urban and rural Bangladeshi children including the risk factors associated with vitamin D deficiency are also evaluated. Methods: A multi-centre (urban and rural based), cross sectional study was done from July 2016 to June 2017, using serum 25(OH) vitamin D3 as a marker of nutritional vitamin D status. Urban and rural children were taken from Paediatric Outpatient Department, United Hospital Limited. Dhaka and Medical Outpatient Department, Upazila Health Complex, Ghatail, Tangail respectively. Children of 1-10 years age attending OPD with mild undernutrition (<–1 SD z score) and/or clinical features suggestive of vitamin D deficiency were included in the study. Results: A total 150 children were studied with 102 (68.0%) urban and 48 (32.0%) rural children. Hypovitaminosis D (25-OHD <30ng/ml) was found in 75.0% of children. Hypovitaminosis D was found significantly more in urban children (81.0%) compared to rural (62.0%) children (OR=0.382, 95% CI: 0.177-0.822, p value <0.05). Inadequate exposure to sunlight was significantly associated with hypovitaminosis D compared to adequate sun exposure and it was about 2.5 times higher (OR=2.475, 95% CI: 1.139-5.380, p value <0.05). No significant associations of vitamin D deficiency were detected with skin color of children, covering clothes of mother, exclusive breast feeding, limb pain and anthropometric status. Children of higher educated mother (above Secondary School Certificate) (OR=0.412, 95% CI: 0.189-0.900) were more associated with vitamin D deficiency. Conclusion: Vitamin D deficiency (VDD) is prevalent among Bangladeshi children, urban children being more vulnerable to VDD. Adoption of a screening programme for children of all age group and implementation of preventive strategies for VDD through public health policies are strongly recommended. Bangladesh Med Res Counc Bull 2020; 46(2): 134-141

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Vitamin D3 and women's health

GYNECOLOGY ◽

10.26442/20795696.2019.1.190235 ◽

2019 ◽

Vol 21 (1) ◽

pp. 44-51

Author(s):

Iuliia E Dobrokhotova ◽

Ekaterina I Borovkova ◽

Sofya A Zalesskaya ◽

Victoria S Skalnaya ◽

Ivan M Borovkov ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D3 ◽

Negative Impact ◽

Perinatal Outcomes ◽

Hypovitaminosis D ◽

Malignant Neoplasms ◽

Cellular Functions ◽

Prophylactic Drug ◽

Drug Doses

Background. Vitamin D is an essential component that regulates calcium homeostasis and many other cellular functions. Hypovitaminosis D is associated with a risk of osteopenia, obesity, type 1 and type 2 diabetes, malignant neoplasms and immune disorders. Inadequate vitamin D intake during pregnancy increases a risk of pre-eclampsia, preterm birth, low birth weight as well as it has a negative impact on both children’s and adolescents’ health. It is important for the clinician to be known administrating of vitamin D prophylactic and therapeutic regimens according to serum 25(OH)D levels. Aim. To determine causes and effects of vitamin D deficiency and to elaborate ways of their correction. Materials and methods. To write this review a search for domestic and foreign publications in Russian and international search systems (PubMed, eLibrary, etc.) for the last 2-15 years was conducted. The review includes articles from peer-reviewed literature. Results. The article shows that vitamin D has a significant impact on both the cardiovascular, endocrine, digestive, respiratory and other systems functioning and perinatal outcomes that necessitates vitamin D deficiency correction. It provides schemes for effective therapeutic and prophylactic drug doses calculating depending on vitamin D3 blood serum concentration. Conclusion. Preference should be given to cholecalciferol (vitamin D3) due to its better absorption properties and more efficient conversion to active vitamin metabolites (class IIC).

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The effect of supplementation of vitamin D in neurocritical care patients: RandomizEd Clinical TrIal oF hYpovitaminosis D (RECTIFY)

Journal of Neurosurgery ◽

10.3171/2018.11.jns182713 ◽

2020 ◽

Vol 133 (4) ◽

pp. 1103-1112 ◽

Cited By ~ 1

Author(s):

Michael Karsy ◽

Jian Guan ◽

Ilyas Eli ◽

Andrea A. Brock ◽

Sarah T. Menacho ◽

...

Keyword(s):

Patient Outcome ◽

Clinical Trial ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D3 ◽

Neurocritical Care ◽

Hypovitaminosis D ◽

Mean Difference ◽

Saps Ii ◽

Gcs Score

OBJECTIVEHypovitaminosis D is prevalent in neurocritical care patients, but the potential to improve patient outcome by replenishing vitamin D has not been investigated. This single-center, double-blinded, placebo-controlled, randomized (1:1) clinical trial was designed to assess the effect on patient outcome of vitamin D supplementation in neurocritical care patients with hypovitaminosis D.METHODSFrom October 2016 until April 2018, emergently admitted neurocritical care patients with vitamin D deficiency (≤ 20 ng/ml) were randomized to receive vitamin D3 (cholecalciferol, 540,000 IU) (n = 134) or placebo (n = 133). Hospital length of stay (LOS) was the primary outcome; secondary outcomes included intensive care unit (ICU) LOS, repeat vitamin D levels, patient complications, and patient disposition. Exploratory analysis evaluated specific subgroups of patients by LOS, Glasgow Coma Scale (GCS) score, and Simplified Acute Physiology Score (SAPS II).RESULTSTwo-hundred seventy-four patients were randomized (intent-to-treat) and 267 were administered treatment within 48 hours of admission (as-treated; 61.2% of planned recruitment) and monitored. The mean age of as-treated patients was 54.0 ± 17.2 years (56.9% male, 77.2% white). After interim analysis suggested a low conditional power for outcome difference (predictive power 0.12), the trial was halted. For as-treated patients, no significant difference in hospital LOS (10.4 ± 14.5 days vs 9.1 ± 7.9 days, p = 0.4; mean difference 1.3, 95% CI −1.5 to 4.1) or ICU LOS (5.8 ± 7.5 days vs 5.4 ± 6.4 days, p = 0.4; mean difference 0.4, 95% CI −1.3 to 2.1) was seen between vitamin D3 and placebo groups, respectively. Vitamin D3 supplementation significantly improved repeat serum levels compared with placebo (20.8 ± 9.3 ng/ml vs 12.8 ± 4.8 ng/ml, p < 0.001) without adverse side effects. No subgroups were identified by exclusion of LOS outliers or segregation by GCS score, SAPS II, or severe vitamin D deficiency (≤ 10 ng/ml).CONCLUSIONSDespite studies showing that vitamin D can predict prognosis, supplementation in vitamin D–deficient neurocritical care patients did not result in appreciable improvement in outcomes and likely does not play a role in acute clinical recovery.Clinical trial registration no.: NCT02881957 (clinicaltrials.gov)

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Faculty Opinions recommendation of Factors associated with vitamin D deficiency in a population of 2044 HIV-infected patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718330413.793494205 ◽

2014 ◽

Author(s):

John Eisman

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Factors Associated

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Prevalence of Vitamin-D Deficiency in Patients with Acute Coronary Syndrome in Syria

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2016.9.6.5 ◽

2016 ◽

Vol 9 (6) ◽

pp. 3544-3548

Author(s):

Aya Hallak ◽

Malhis Mahmoud ◽

Yaser Abajy Mohammad

Keyword(s):

Vitamin D ◽

Acute Coronary Syndrome ◽

Vitamin D Deficiency ◽

Hypovitaminosis D ◽

Control Group ◽

Coronary Syndrome ◽

Normal Individuals ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D ◽

Coronary Syndromes

The objectives of this study were to estimate the prevalence of vitamin D deficiency in patients with acute coronary syndrome in comparison with normal individuals and study the correlation between these two conditions. We measured the plasma 25-hydroxy vitamin D (25-OH-D) levels in 60 patients with acute coronary syndromes (ACS) of both gender and in 30 age matched control individuals of both gender without any known cardiovascular or systemic diseases. The levels of 25-OH-D were measured by ELISA method and the results were statically analyzed to find out any possible correlation. We classified the cases according to their plasma 25(OH)D levels. 25(OH)D levels of ≥ 30 ng/ml were considered normal, levels < 30 and > 20 ng/ml were classified as insufficient, while levels of ≤ 20 ng/ml were classified as deficient. In the current study the prevalence of hypovitaminosis D in the patients group was much higher than it was in the control group. Vitamin D deficiency was observed in 80% and insufficiency in 13% of total patients of ACS, there by bringing the total count to 93%. Whereas only 7% of the patients had adequate vitamin D levels. Thus, these results indicate the existence of a significant correlation between the vitamin D deficiency and ACS in comparison to healthy controls

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Vitamin D Deficiency in Testicular Cancer Survivors: A Systematic Review

International Journal of Molecular Sciences ◽

10.3390/ijms22105145 ◽

2021 ◽

Vol 22 (10) ◽

pp. 5145

Author(s):

Giuseppe Schepisi ◽

Caterina Gianni ◽

Sara Bleve ◽

Silvia De Padova ◽

Cecilia Menna ◽

...

Keyword(s):

Vitamin D ◽

Testicular Cancer ◽

Vitamin D Deficiency ◽

Molecular Mechanisms ◽

Hypovitaminosis D ◽

Young Males ◽

Report Data ◽

Testicular Cancer Survivors ◽

Patients Experience

Testicular cancer (TC) is the most frequent tumor in young males. In the vast majority of cases, it is a curable disease; therefore, very often patients experience a long survival, also due to their young age at diagnosis. In the last decades, the role of the vitamin D deficiency related to orchiectomy has become an increasingly debated topic. Indeed, vitamin D is essential in bone metabolism and many other metabolic pathways, so its deficiency could lead to various metabolic disorders especially in long-term TC survivors. In our article, we report data from studies that evaluated the incidence of hypovitaminosis D in TC survivors compared with cohorts of healthy peers and we discuss molecular mechanisms and clinical implications.

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Factors associated with vitamin D deficiency in a multicultural inflammatory bowel disease cohort

Frontline Gastroenterology ◽

10.1136/flgastro-2012-100231 ◽

2012 ◽

Vol 4 (1) ◽

pp. 51-56 ◽

Cited By ~ 17

Author(s):

Sukhdev Chatu ◽

Vivek Chhaya ◽

Rosamund Holmes ◽

Penny Neild ◽

Jin-Yong Kang ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Bowel Disease ◽

Factors Associated ◽

Inflammatory Bowel

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The Incidence of and Factors Associated with Vitamin D Deficiency in Newly Diagnosed Children with Cancer

Nutrition and Cancer ◽

10.1080/01635581.2016.1180408 ◽

2016 ◽

Vol 68 (5) ◽

pp. 756-761 ◽

Cited By ~ 6

Author(s):

Dildar Bahar Genc ◽

Sema Vural ◽

Gulperi Yagar

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Newly Diagnosed ◽

Children With Cancer ◽

Factors Associated

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Association of Vitamin D Deficiency in Newly Diagnosed Pulmonary Tuberculosis

10.53350/pjmhs2115102572 ◽

2021 ◽

Vol 15 (10) ◽

pp. 2572-2573

Author(s):

Khalil Ullah ◽

Sajid Ur Rehman ◽

Ramsha Nadeem ◽

Muhammad Abubakar ◽

Qasim Raza

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Sampling Technique ◽

Hypovitaminosis D ◽

Control Group ◽

Sputum Smear ◽

Study Group ◽

Serum Vitamin D

Aim: Relationship between Vitamin D deficiency and pulmonary tuberculosis. Methodology: Study duration: November 2020 to April 2021 Sampling technique: A case-control study Setting: Hayatabad Medical Complex, Peshawar It included 30 adult newly identified sputum-quality pulmonary tuberculosis patients and 30 age and sex matched healthy cases as controls. All cases had undergone a thorough medical examination and repeated laboratory tests, including vitamin D, calcium, and sputum for AFB and X-ray chest. Results: Majority were males (88%). In the Study group, BMI decreased significantly i.e. 19.0 vs 23.5. Serum vitamin D concentrations were significantly lower in the tuberculosis group i.e. 17.9ng/dl than in the control group 24.8ng/dl. Mean of serum albumin in the control group was 3.9 ng/dl whereas 2.9 ng/dl in the study group. Conclusion: Hypovitaminosis D was associated with more severe medical symptoms, increased sputum smear positivity and large lesions on chest radiographs in patients with pulmonary tuberculosis. Keywords: Vitamin D, Pulmonary Tuberculosis, Sputum

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