Cutaneous pleomorphic adenoma of the periocular region – a case series

Objectives: Surgery for recurrent pleomorphic adenoma (PA) can be challenging and may increase the risk of operative complications, particularly facial nerve weakness. As observation may be a viable alternative to surgery for slow-growing tumors, our objective was to assess the growth rate of recurrent PAs. Study Design: This study is a case series of patients at our tertiary academic medical center with recurrent PA. Two magnetic resonance images (MRI) were compared; total volume (TV) of recurrent tumor on both studies was calculated to obtain our main outcomes of percent change in TV and tumor growth rate. Results: Fourteen patients with recurrent PA had a median interval time between MRI of 12.8 months. Though growth rates were variable, the median continuous compound growth per year was 10.2%. Notably, 3 patients (21%) had no growth, and 2 patients (14%) had a reduction in TV. Conclusions: The median growth rate for enlarging tumors is estimated at 10.2% per year. Due to variability, tumor growth rate should be estimated on an individual patient basis. For slow-growing tumors, physicians may weigh the risk of this slow growth with the morbidity of reoperation.

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Pleomorphic adenoma of the submandibular gland: an evolving change in practice following review of a personal case series

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-007-0378-x ◽

2007 ◽

Vol 264 (12) ◽

pp. 1447-1452 ◽

Cited By ~ 7

Author(s):

Nazia Munir ◽

Patrick J. Bradley

Keyword(s):

Submandibular Gland ◽

Pleomorphic Adenoma ◽

Case Series ◽

Change In Practice ◽

Personal Case

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Uncommon occurrence of pleomorphic adenoma in submandibular salivary gland in old age males: case series

International Surgery Journal ◽

10.18203/2349-2902.isj20200842 ◽

2020 ◽

Vol 7 (3) ◽

pp. 900

Author(s):

M. S. Kalyan Kumar ◽

R. Shyamsundar ◽

M. Sabari Girieasen ◽

R. Kannan ◽

S. Nedunchezhiyan

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Pleomorphic Adenoma ◽

Benign Lesion ◽

Case Series ◽

Surgical Excision ◽

Needle Aspiration ◽

Submandibular Salivary Gland ◽

Biopsy Report ◽

Needle Aspiration Cytology

Pleomorphic adenoma is the most common tumor of the benign salivary gland neoplasms, the submandibular gland is the second most common site of PA after the parotid gland. Authors present 3 series case of pleomorphic adenoma in submandibular salivary gland in institution which were admitted in institution within a month interval. Fine needle aspiration cytology (FNAC) of all 3 cases proved to be benign lesion arising from submandibular salivary gland. All 3 cases underwent excision in to and the postoperative period was uneventful. DT removed on 3rd POD and discharged in POD 10. Biopsy report proved to be pleomorphic adenoma in all cases. past studies showed pleomorphic adenoma most commonly occurs in the parotid gland and its occurrence in the submandibular salivary gland is uncommon. Also, age occurrence involves 30s-50s and is more common in females. But all this case was male and occurred in older age group. Early intervention with surgical excision in toto after definite confirmation with FNAC is the treatment of choice in preventing its malignant transformation.

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Frequency of surgical complications and recurrence rate after extracapsular dissection of benign tumors of the parotid.

The Professional Medical Journal ◽

10.29309/tpmj/2021.28.07.5918 ◽

2021 ◽

Vol 28 (7) ◽

pp. 983-986

Author(s):

Muhammad Arham ◽

◽

Jahangir Sarwar Khan ◽

Muhammad Arish ◽

Naveed Akhtar Malik ◽

...

Keyword(s):

Facial Nerve ◽

Pleomorphic Adenoma ◽

Recurrence Rate ◽

Surgical Complications ◽

Case Series ◽

Lesion Size ◽

Benign Tumors ◽

Warthin Tumor ◽

Extracapsular Dissection ◽

Medical University

Objective: To determine surgical complications and recurrence rate in patients with benign lesions of the parotid undergoing extracapsular dissection. Study Design: Case Series. Setting: Department of Surgery, Rawalpindi Medical University, Rawalpindi. Period: January 2010 and December 2018. Material & Methods: The hospital records of all 50 patients who underwent extracapsular dissection with a diagnosis of either Pleomorphic adenoma or War thin tumor between reviewed retrospectively. Data regarding demographics, tumor, complications and recurrence was collected. Results: Out of 50 patients, 40 were males and 10 were females with age ranging from 26 to 52 years and mean age of 42 years. 44 of 50 parotid lumps were diagnosed as Pleomorphic adenoma and 6 were cases of Warthin tumor. The range of lesion size was 1.5 to 3 cm. 15 (30%) patients suffered from transient facial nerve weakness, whereas only 1 (2%) sustained a facial nerve injury which required repair. There was no case of Frey syndrome, sialocele and hematoma, however, salivary fistula was seen in 1 (2%) patient. Capsule rupture during surgery occurred in 15 (30%) patients and recurrence was seen in only 1 patient (2%). Conclusion: Extracapsular dissection has low recurrence rate, very few complications and is a safe and effective treatment for Pleomorphic adenoma and Warthin tumor.

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Aspiration cytology of pleomorphic adenoma with squamous metaplasia: A case series and literature review illustrating diagnostic challenges

Diagnostic Cytopathology ◽

10.1002/dc.24915 ◽

2021 ◽

Author(s):

Joshua J. X. Li ◽

Joanna K. M. Ng ◽

Eric H. L. Lau ◽

Amy B. W. Chan

Keyword(s):

Literature Review ◽

Pleomorphic Adenoma ◽

Squamous Metaplasia ◽

Case Series ◽

Aspiration Cytology

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Pleomorphic Adenoma of Hard Palate: A Case Series

Otorhinolaryngology Clinics - An International Journal ◽

10.5005/jp-journals-10003-1345 ◽

2020 ◽

Vol 12 (1) ◽

pp. 11-13

Author(s):

Seema R Gupta ◽

Vandana P Thorawade ◽

Mohammad Hanif MS Khan

Keyword(s):

Pleomorphic Adenoma ◽

Hard Palate ◽

Case Series

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A rare case series of chondroid syringoma in three young patients

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20213427 ◽

2021 ◽

Vol 9 (9) ◽

pp. 2821

Author(s):

Nechal Kaur ◽

Neelam Gupta ◽

Vikas Dubey ◽

Neetu Bala

Keyword(s):

Salivary Glands ◽

Pleomorphic Adenoma ◽

Rare Case ◽

Young Patients ◽

Case Series ◽

Mixed Tumour ◽

Aged Patients ◽

Younger Patients ◽

Chondroid Syringoma

Chondroid syringoma is also known as mixed tumour of the skin. It is a rare, biphasic cutaneous neoplasm similar to pleomorphic adenoma of salivary glands. Because of its rarity, many cases are misdiagnosed in the initial stages as cysts or other cutaneous adnexal neoplasms and are often identified only after being sent for histopathological examination.Although it usually presents in middle and older aged patients, we are presenting three younger patients with Chondroid syringoma, located over the back, nose and cheek, respectively.

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Clinical analysis of 109 cases of lacrimal gland pleomorphic adenoma

International Journal of Ophthalmology ◽

10.18240/ijo.2021.12.07 ◽

2021 ◽

Vol 14 (12) ◽

pp. 1852-1857

Author(s):

Rui Liu ◽

◽

Hong Zhang ◽

Xin Ge ◽

Jian-Min Ma ◽

...

Keyword(s):

Pleomorphic Adenoma ◽

Malignant Transformation ◽

Lacrimal Gland ◽

Histopathological Examination ◽

Case Series ◽

Bone Destruction ◽

Clinical Analysis ◽

Ki 67 ◽

Initial Surgery ◽

Clinical Records

AIM: To monitor the prognosis of patients with lacrimal gland pleomorphic adenoma (LGPA) following surgical resection within the past 10y. The factors affecting patient prognosis are analyzed and the experience of surgical treatment is summarized. METHODS: In this retrospective, comparative case series, clinical records from 109 cases of LGPA treated chiefly at the same institution between November 2009 and May 2019 were reviewed. All 109 patients underwent surgery, histopathological examination, and imaging examination. For patients who underwent surgery for the first time, LGPA could be resected completely, including tumor and capsule tissues, using a surgical approach via the eyebrow arch or double eyelid crease. RESULTS: The ratio of males to females was 1:1.60, the ages ranged from 19 to 74 years old with a mean age of 43.64±13.07 years old, and the ratio of left to right eyes was 1:1.37. A total of 109 patients underwent surgical excision and five of these received radiotherapy after malignant transformation. Of these patients, 15 were lost to follow up within the April 1, 2020 deadline and 1 was diagnosed as a recurring pathology. The 5-year recurrence rate for 86 patients who underwent initial surgery was 7.27%. Single factor analysis revealed that the course of disease, bone destruction, invasion of surrounding tissues, tumor size, capsule integrity, and expression of Ki-67 were statistically significant (P<0.05). Binomial Logistic regression analysis showed that capsule integrity was a risk factor influencing recurrence (P=0.008). CONCLUSION: LGPA has a risk of recurrence and potential for malignant transformation. Complete removal of the tumor and capsule in the initial surgery is a key factor in preventing recurrence.

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