The chapter starts with a theoretical sociological, psychological, and physiological framework for the relationships between psychosocial factors and coronary heart disease (CHD). This is followed by a review of the scientific evidence supporting such an association. Individual behaviours and coping mechanisms as well as environmental conditions of relevance for CHD are described. In particular, type A and D behaviour, depressive states, covert coping, social support and social network, socioeconomic conditions, as well as theoretical work environment models of relevance for CHD (job strain, effort-reward imbalance, organizational justice and leadership) are discussed. The remaining part of the chapter surveys the results from controlled studies of the effects of psychosocial interventions. There is accumulating evidence from such controlled studies that risk factors for CHD can be favourably influenced.