A DOE Approach to Investigate the Influence of Process-Parameters and Composition on the Stability of Emulsions Stabilized by Marine Polysaccharides Prepared by High-Pressure Homogenization

2014 ◽  
Vol 35 (6) ◽  
pp. 789-798 ◽  
Author(s):  
Kirsten Petersen ◽  
Hartwig Steckel
Keyword(s):  
High Pressure ◽  
Process Parameters ◽  
High Pressure Homogenization ◽  
Influence Of Process Parameters ◽  
The Stability

scholarly journals INVESTIGATION OF THE ROBUST STABILITY OF SYSTEM WITH DELAY / SISTEMŲ, KURIŲ SAVYBĖ VĖLINTI, TYRIMAS PATIKIMAM STABILUMUI NUSTATYTI

2015 ◽  
Vol 7 (3) ◽  
pp. 314-316
Author(s):  
Andrei Shumski ◽  
Dzmitry Karpovich
Keyword(s):  
Robust Stability ◽  
Process Parameters ◽  
Smith Predictor ◽  
Influence Of Process Parameters ◽  
System Parameters ◽  
System With Delay ◽  
The Stability ◽  
Robust Systems

The paper is devoted to investigation of the robust stability of system with delay. The influence of process parameters on the stability of the whole system is tested and impact to the system parameters using the Smith predictor for robust systems is defined. Pristatomas sistemų, kurioms būdingas vėlinimas, tyrimas patikimam stabilumui nustatyti. Ištirta proceso parametrų įtaka visos sistemos stabilumui ir įvertinta Smito prognozės taikymo nauda numatant patikimas sistemas.

Systematic Development and Optimization of an in-situ Gelling System for Moxifloxacin Ocular Nanosuspension using High-pressure Homogenization with an Improved Encapsulation Efficiency

2018 ◽  
Vol 24 (13) ◽  
pp. 1434-1445 ◽  
Author(s):  
Lalit Kumar Khurana ◽  
Romi Singh ◽  
Harinder Singh ◽  
Manju Sharma
Keyword(s):  
High Pressure ◽  
Process Parameters ◽  
Encapsulation Efficiency ◽  
Quality By Design ◽  
Polynomial Equation ◽  
Single Type ◽  
Application Site ◽  
High Pressure Homogenization ◽  
In Situ Gelling

Background: The objective of this study was to apply Quality by Design (QbD) principles on process parameter optimization for the development of hybrid delivery system (combination of (SLNs) and In-situ gelling system) for hydrophilic drug Moxifloxacin Hydrochloride (MOX) to achieve its controlled delivery, which otherwise may not be possible through single type of technology. Methods: Risk assessment studies were carried out to identify probable risks influencing CQAs on the product. In design of experiments (DoE), the process parameters (independent variables) i.e., chiller temperature X1, High Pressure Homogenization (HPH) pressure X2, and HPH cycles X3 were optimized using a three-factor two level face-centered central composite design to streamline the influence on three responses, namely encapsulation efficiency Y1, particle size Y2 and outlet temperature Y3. Independent and dependent variables were analyzed to establish a full-model second-order polynomial equation. F value is used to confirm the omission of insignificant parameters/interactions to derive a reduced-model polynomial equation to predict the Y1, Y2 and Y3 for optimized moxifloxacin in situ gelled nanosuspension. Results: Desirability plots showed the effects of X1, X2, and X3 on Y1, Y2 and Y3, respectively. The design space is generated to obtain optimized process parameters viz. chiller temperature (-5°C), HPH pressure 800 – 900 bar and 8 cycles that resulted in nanosuspension with ≈ 500 nm size, encapsulation efficiency >65% and final formulation temperature <23°C that were necessary to maintain the formulation in a liquid state. Conclusion: Quality by Design (QbD) approach is recently been encouraged by regulatory bodies to improve the quality of the finished product. This approach proved to be a useful tool in the development of robust nanosuspension of highly hydrophilic drugs with improved efficiency. Results indicate that such hybrid gel systems can be used to control the release of SLNs from application site and prolong their action in a sustained manner.

scholarly journals Stability Aspects of Non-Dairy Milk Alternatives

2021 ◽  
Author(s):  
Jyotika Dhankhar ◽  
Preeti Kundu
Keyword(s):  
High Pressure ◽  
Physical Stability ◽  
Bovine Milk ◽  
Processing Parameters ◽  
High Pressure Homogenization ◽  
Antibiotic Residues ◽  
Plant Materials ◽  
Milk Products ◽  
The Stability ◽  
Dairy Milk

In recent years, plant-based milk products, commonly called as non-dairy milk alternatives have gained high popularity due to concerns associated with bovine milk like lactose intolerance, allergies, hypercholesterolemia, and pesticide and antibiotic residues. Important strategies for manufacture of non-dairy milk alternatives involve disintegration of plant materials in aqueous medium; its homogenization and addition of some additives to attain a consistency and appearance similar to that of bovine milk. Different range of ingredients are added to non-dairy milk alternatives such as oils, emulsifiers, thickeners, antioxidants, minerals etc. The main problem associated with non-dairy milk alternatives is generally linked with its stability. Stability is a crucial factor that governs the sensory properties and overall acceptance of non-dairy milk alternatives. Differences in processing parameters and molecular interaction mechanisms affect the stability of emulsions as well as the stability of non-dairy milk manufactured thereof. Various treatments like thermal treatment, non-thermal processing (ultra high pressure homogenization, pulsed electric field, ultrasonication), addition of emulsifiers are effective in achieving the stability of non-dairy milks. The present chapter aims to summarize the various factors contributing to the physical stability of non-dairy milk alternatives like appearance, consistency, emulsion stability, and the approaches required to maintain it.

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