Near-infrared spectroscopy-derived total haemoglobin as an indicator of changes in muscle blood flow during exercise-induced hyperaemia

2020 ◽  
Vol 38 (7) ◽  
pp. 751-758 ◽  
Author(s):  
Thiago Silveira Alvares ◽  
Gustavo Vieira de Oliveira ◽  
Rogério Soares ◽  
Juan Manuel Murias
Keyword(s):  
Blood Flow ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Muscle Blood Flow ◽  
Total Haemoglobin ◽  
Exercise Induced

Near infrared spectroscopy-guided exercise training for claudication in peripheral arterial disease

2018 ◽  
Vol 26 (5) ◽  
pp. 471-480 ◽  
Author(s):  
Jonathan R Murrow ◽  
Jared T Brizendine ◽  
Bill Djire ◽  
Hui-Ju Young ◽  
Stephen Rathbun ◽  
...  
Keyword(s):  
Blood Flow ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Muscle Blood Flow ◽  
Arterial Disease ◽  
Walking Program ◽  
Peripheral Arterial ◽  
Walking Time ◽  
Mitochondrial Capacity

Rationale Supervised treadmill exercise for claudication in peripheral arterial disease is effective but poorly tolerated because of ischemic leg pain. Near infrared spectroscopy allows non-invasive detection of muscle ischemia during exercise, allowing for characterization of tissue perfusion and oxygen utilization during training. Objective We evaluated walking time, muscle blood flow, and muscle mitochondrial capacity in patients with peripheral artery disease after a traditional pain-based walking program and after a muscle oxygen-guided walking program. Method and results Patients with peripheral artery disease trained thrice weekly in 40-minute-long sessions for 12 weeks, randomized to oxygen-guided training ( n = 8, age 72 ± 9.7 years, 25% female) versus traditional pain-based training ( n = 10, age 71.6 ± 8.8 years, 20% female). Oxygen-guided training intensity was determined by maintaining a 15% reduction in skeletal muscle oxygenation by near infrared spectroscopy rather than relying on symptoms of pain to determine exercise effort. Pain free and maximal walking times were measured with a 12-minute Gardner treadmill test. Gastrocnemius mitochondrial capacity and blood flow were measured using near infrared spectroscopy. Baseline pain-free walking time was similar on a Gardner treadmill test (2.5 ± 0.9 vs. 3.6 ± 1.0 min, p = 0.5). After training, oxygen-guided cohorts improved similar to pain-guided cohorts (pain-free walking time 6.7 ± 0.9 vs. 6.9 ± 1.1 min, p < 0.01 for change from baseline and p = 0.97 between cohorts). Mitochondrial capacity improved in both groups but more so in the pain-guided cohort than in the oxygen-guided cohort (38.8 ± 8.3 vs. 14.0 ± 9.3, p = 0.018). Resting muscle blood flow did not improve significantly in either group with training. Conclusions Oxygen-guided exercise training improves claudication comparable to pain-based training regimens. Adaptations in mitochondrial function rather than increases in limb perfusion may account for functional improvement. Increases in mitochondrial oxidative capacity may be proportional to the degree of tissue hypoxia during exercise.

Measurement of Respiratory Muscle Blood Flow in Humans Using Near Infrared Spectroscopy and Indocyanine Green

2008 ◽  
Vol 40 (Supplement) ◽  
pp. S304
Author(s):  
Jordan A. Guenette ◽  
Ioannis Vogiatzis ◽  
Spyros Zakythinos ◽  
Dimitrios Athanasopoulos ◽  
Spyretta Golemati ◽  
...  
Keyword(s):  
Blood Flow ◽  
Infrared Spectroscopy ◽  
Indocyanine Green ◽  
Near Infrared Spectroscopy ◽  
Respiratory Muscle ◽  
Near Infrared ◽  
Muscle Blood Flow

scholarly journals Muscle Blood Flow and Oxygen Utilization Measured by Near-Infrared Spectroscopy during Handgrip Exercise in Chronic Respiratory Patients

2009 ◽  
Vol 21 (3) ◽  
pp. 231-238 ◽  
Author(s):  
Kiyokazu Sekikawa ◽  
Kazuyuki Tabira ◽  
Noriko Sekikawa ◽  
Kotarou Kawaguchi ◽  
Makoto Takahashi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Muscle Blood Flow ◽  
Handgrip Exercise ◽  
Oxygen Utilization

scholarly journals Reliability of muscle blood flow and oxygen consumption response from exercise using near-infrared spectroscopy

2017 ◽  
Vol 103 (1) ◽  
pp. 90-100 ◽  
Author(s):  
Adam A. Lucero ◽  
Gifty Addae ◽  
Wayne Lawrence ◽  
Beemnet Neway ◽  
Daniel P. Credeur ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Muscle Blood Flow

scholarly journals Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion

1999 ◽  
Author(s):  
Lelia A. Paunescu ◽  
Claudia Casavola ◽  
Maria-Angela Franceschini ◽  
Sergio Fantini ◽  
Lew Winter ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Muscle Blood Flow ◽  
Venous Occlusion ◽  
Calf Muscle

Tissue Oxygenation by Near-Infrared Spectroscopy and Muscle Blood Flow During Isometric Contractions of the Forearm

1999 ◽  
Vol 24 (3) ◽  
pp. 216-230 ◽  
Author(s):  
Andrew Hicks ◽  
Stuart Mcgill ◽  
Richard L. Hughson
Keyword(s):  
Blood Flow ◽  
Infrared Spectroscopy ◽  
Doppler Ultrasound ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Tissue Oxygenation ◽  
Muscle Blood Flow ◽  
Venous Blood ◽  
Muscle Oxygenation ◽  
Isometric Contractions

The relationship between tissue oxygenation measured by near-infrared spectroscopy (NIRS) and forearm muscle blood flow (FBF) measured by Doppler ultrasound was tested during isometric contractions at 10 and 30% maximal voluntary contraction (MVC) under conditions of normoxia and hypoxia (14% inspired O2). Six subjects maintained contractions at 10% MVCfor 5 min and at 30% for 2 min in both gas conditions. FBF was elevated during exercise at 10% MVC in hypoxia compared to normoxia, but there was no further increase in flow at 30% MVC. Median power frequency calculations from electromyographic recordings suggested progressive development of fatigue throughout both 10 and 30% MVC contractions. NIRS indicated no change in muscle oxygenation at 10% MVC, but deep venous blood O2 saturation was reduced in normoxia and more so in hypoxia. At 30% MVC, both NIRS and venous O2 saturation were reduced, with no effect of hypoxia on the NIRS signal. While NIRS might provide an indication of muscle oxygenation during isometric exercise, the conflicting findings for NIRS and direct venous blood sampling at 10 vs. 30% MVC suggest caution in the application of this noninvasive technique. Key words: exercise, Doppler ultrasound, venous blood. O2 saturation, hemoglobin

scholarly journals Measurement of muscle blood flow and O2 uptake via near-infrared spectroscopy using a novel occlusion protocol

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Joshua J. Dennis ◽  
Chad C. Wiggins ◽  
Joshua R. Smith ◽  
Jennifer M. J. Isautier ◽  
Bruce D. Johnson ◽  
...  
Keyword(s):  
Blood Flow ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Muscle Blood Flow ◽  
Arterial Occlusion ◽  
Vascular Occlusion ◽  
Voluntary Contraction ◽  
Handgrip Exercise ◽  
Perfect Agreement

AbstractWe describe here a novel protocol that sequentially combines venous followed by arterial occlusions to determine muscle blood flow and O2 uptake from a single measurement point using near-infrared spectroscopy (NIRS) during handgrip exercise. NIRS data were obtained from the flexor digitorum superficialis (FDS) muscle on the dominant arm of 15 young, healthy adults (3 women; 26 ± 7 years; 78.6 ± 9.1 kg). Participants completed a series of 15-s static handgrip contractions at 20, 40 and 60% of maximal voluntary contraction (MVC) immediately followed by either a: (i) venous occlusion (VO); (ii); arterial occlusion (AO); or venous then arterial occlusion (COMBO). Each condition was repeated 3 times for each exercise-intensity. The concordance correlation coefficient (CCC) and robust linear mixed effects modeling were used to determine measurement agreement between vascular occlusion conditions. FDS muscle blood flow ($${\dot{\text{Q}}}_{{{\text{FDS}}}}$$ Q ˙ FDS ) and conductance ($${\text{C}}_{{{\text{FDS}}}}$$ C FDS ) demonstrated strong absolute agreement between VO and COMBO trials from rest up to 60%MVC, as evidenced by high values for CCC (> 0.82) and a linear relationship between conditions that closely approximated the line-of-identity (perfect agreement). Conversely, although FDS muscle O2 uptake ($${{\dot {\text{V}}}}{{\text{O}}_{2{\text{FDS}}}}$$ V ˙ O 2 FDS ) displayed “substantial” to “near perfect” agreement between methods across exercise intensities (i.e., CCC > 0.80), there was a tendency for COMBO trials to underestimate $${{\dot {\text{V}}}}{{\text{O}}_{2{\text{FDS}}}}$$ V ˙ O 2 FDS by up to 7%. These findings indicate that the COMBO method provides valid estimates of $${\dot {\text{Q}}}_{{\text{FDS}}}$$ Q ˙ FDS and, to a slightly lesser extent, $${{\dot {\text{V}}}}{{\text{O}}_{2{\text{FDS}}}}$$ V ˙ O 2 FDS at rest and during static handgrip exercise up to 60%MVC. Practical implications and suggested improvements of the method are discussed.

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