Re: Thyroid hypofunction in aging testicular cancer survivors by Nome et al.

2022 ◽  
pp. 1-1
Author(s):  
Ragnhild Veline Nome ◽  
Milada Cvancarova Småstuen ◽  
Sophie Dorothea Fosså ◽  
Cecilie E. Kiserud ◽  
Bjørn Olav Åsvold ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cancer Survivors ◽  
Testicular Cancer Survivors

scholarly journals Psychological Needs Satisfaction, Self-Rated Health and the Mediating Role of Exercise Among Testicular Cancer Survivors

2021 ◽  
Vol 15 (2) ◽  
pp. 155798832110126
Author(s):  
Anika R. Petrella ◽  
Catherine M. Sabiston ◽  
Madison F. Vani ◽  
Andrew Matthew ◽  
Daniel Santa Mina
Keyword(s):  
Mental Health ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Psychological Needs ◽  
Basic Psychological Needs ◽  
Exercise Behavior ◽  
Physical And Mental Health ◽  
Self Rated Health ◽  
Needs Satisfaction ◽  
Testicular Cancer Survivors

Exploring tenets of basic psychological needs theory, the objective of this study was to examine the association between psychological needs satisfaction, exercise behavior, and physical and mental health among testicular cancer survivors. The present study investigated whether psychological needs satisfaction was directly associated with increased self-rated health, and if this relationship was mediated by engagement in exercise. Testicular cancer survivors ( N = 135; Mage = 32.45; SD = 7.63) self-reported current psychological needs satisfaction, exercise behavior, and perceived global physical and mental health during routine oncology visits. Associations were examined using path analysis. Psychological needs satisfaction was a positive correlate of both self-rated physical and mental health in this sample, and exercise mediated the association between needs satisfaction and self-rated physical health. This study supports the assumptions underpinning basic psychological needs theory in this unique clinical population. Based on the findings, exercise engagement represents one mechanism associated with perceived health after cancer. Supportive care interventions should aim to enhance satisfaction of psychological needs and investigate exercise as a mechanism underpinning the relationship between needs satisfaction and perceived health in testicular cancer survivors.

A study of coping in long-term testicular cancer survivors

2010 ◽  
Vol 15 (2) ◽  
pp. 146-158 ◽  
Author(s):  
Robert Rutskij ◽  
Torfinn Gaarden ◽  
Roy Bremnes ◽  
Olav Dahl ◽  
Arnstein Finset ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Cancer Survivors ◽  
Testicular Cancer Survivors

scholarly journals Quality of life of testicular cancer survivors and the relationship with sociodemographics, cancer-related variables, and life events

2005 ◽  
Vol 14 (3) ◽  
pp. 251-259 ◽  
Author(s):  
J. Fleer ◽  
H. J. Hoekstra ◽  
D. T. Sleijfer ◽  
M. A. Tuinman ◽  
E. C. Klip ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Life Events ◽  
Testicular Cancer Survivors ◽  
The Relationship

scholarly journals Immunosenescence profile and expression of the aging biomarker (p16INK4a) in testicular cancer survivors treated with chemotherapy.

2019 ◽  
Author(s):  
Maria Teresa Bourlon ◽  
Hugo E Velazquez ◽  
Juan Hinojosa ◽  
Luis Orozco ◽  
Ricardo Rios-Corzo ◽  
...  
Keyword(s):  
T Cells ◽  
T Lymphocytes ◽  
Testicular Cancer ◽  
Cancer Survivors ◽  
Germ Cell Tumors ◽  
Lymphocyte Subpopulations ◽  
Lower Percentage ◽  
Rank Test ◽  
P16 Ink4a ◽  
Testicular Cancer Survivors

Abstract Background Cytotoxic chemotherapy can cure advanced germ cell tumors. Nevertheless, cancer treatment may induce cellular senescence and accelerate molecular aging. The aging process implies an increase of cells expressing p16 INK4a and changes in lymphocyte subpopulations. Our aim was to study the potential induction of premature immunosenescence in testicular cancer survivors (TCS) exposed to chemotherapy. Patients and methods Case-control study of TCS treated with chemotherapy (≥3 BEP cycles, disease-free ≥3 months) compared with healthy controls. Peripheral blood mononuclear cells were isolated, and lymphocyte subpopulations were analyzed by flow cytometry. p16 INK4a expression in T cells was measured using qPCR. Percentage of lymphocyte subpopulations associated with immunosenescence and p16 INK4a expression in TCS compared to controls using the Wilcoxon signed-rank test. Results We included 16 cases and 16 controls. The median of age was 27 years (24-54) and median time on surveillance was 26.5 months (3-192). TCS had a lower percentage of total T cells and CD4+ T cells in total lymphocytes. Among the CD4+ T lymphocytes, TCS had a lower naïve CD4+ and an increased memory CD4+ cells. Within the CD8+ T lymphocytes, TCS exhibited a decrease in the percentage of naïve cells and an increase in CD8+CD45RA+CD57+ cells. TCS also exhibited a decreased memory CD19+ B cells compared to the controls. The relative expression of p16 INK4a in T cells was higher in TCS compared to the controls [1.33 (IQR 0.93-2.23): p=0.048). Conclusion TCS showed an increase in the expression of the aging biomarker p16 INK4a and a lymphocyte phenotype associated with immunosenescence; characterized by a decrease in naïve cells, and concomitant increment of memory cells. This phenomenon might contribute to the development of an immune risk profile, which is associated with an increased rate of infections and a diminished effect of vaccination in the elderly population. Further studies are warranted to define the clinical implications of this alteration in TCS.

scholarly journals Longitudinal kidney function outcome in aging testicular cancer survivors

2020 ◽  
Vol 59 (4) ◽  
pp. 467-474
Author(s):  
Ragnhild V. Nome ◽  
Milada Cvancarova Småstuen ◽  
Trine Bjøro ◽  
Cecilie E. Kiserud ◽  
Sophie D. Fosså
Keyword(s):  
Testicular Cancer ◽  
Cancer Survivors ◽  
Kidney Function ◽  
Testicular Cancer Survivors

Cisplatin-Induced Long-Term Hearing Impairment Is Associated With Specific Glutathione S-Transferase Genotypes in Testicular Cancer Survivors

2007 ◽  
Vol 25 (6) ◽  
pp. 708-714 ◽  
Author(s):  
Jan Oldenburg ◽  
Sigrid M. Kraggerud ◽  
Milada Cvancarova ◽  
Ragnhild A. Lothe ◽  
Sophie D. Fossa
Keyword(s):  
Testicular Cancer ◽  
Cancer Survivors ◽  
Hearing Impairment ◽  
Glutathione S Transferase ◽  
Functional Polymorphisms ◽  
Hearing Ability ◽  
Interindividual Variations ◽  
Glutathione S Transferases ◽  
Testicular Cancer Survivors

Purpose Cisplatin, a cornerstone of combination chemotherapy in the treatment of testicular cancer, induces hearing impairment with considerable interindividual variations. These differences might be a result of functional polymorphisms in cisplatin-detoxifying enzymes like glutathione S-transferases (GSTs). Patients and Methods We identified 173 cisplatin-treated testicular cancer survivors (TCSs) who had participated in a long-term survey that included audiometric testing and lymphocyte sampling. The hearing decibel thresholds at 4,000 Hz were categorized into leveled scales by normative decibel percentiles. Known functional polymorphisms (positive or negative) in GSTT1 and GSTM1 and codon 105 A/G (Ile/Val) in GSTP1 were analyzed by multiplex polymerase chain reaction, followed by restriction enzyme cutting, and separated by gel electrophoresis. Results The risk of having an inferior audiometric result was more than four times higher in TCSs with 105Ile/105Ile-GSTP1 or 105Val/105Ile-GSTP1 compared with 105Val/105Val-GSTP1 (odds ratio [OR] = 4.21; 95% CI, 1.99 to 8.88; P < .001 when modeled by ordinal logistic regression [OLR]). GSTM1 positivity was detrimental for hearing ability. Two combined genotypes were associated with hearing ability. The presence of pattern 1 (GSTT1 positive, GSTM1 positive, and 105Ile/105Ile-GSTP1) was associated with hearing impairment (OR = 2.76; 95% CI, 1.35 to 5.64; P = .005, OLR). TCSs with pattern 2 (GSTT1 positive, GSTM1 positive, and 105Val/105Val-GSTP1) had better hearing ability than TCSs without this pattern (OR = 5.35; 95% CI, 2.25 to 12.76; P < .001, OLR). Conclusion The presence of both alleles of 105Val-GSTP1 offered protection against cisplatin-induced hearing impairment. Two genotype patterns with good and poor protection against cisplatin-induced ototoxicity were identified.

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