On strong deviation theorems concerning array of dependent random sequence

2021 ◽  
pp. 1-10
Author(s):  
Ping Hu ◽  
Mengru Chen ◽  
Shu Chen ◽  
Zhong-zhi Wang
Keyword(s):  
Random Sequence ◽  
Strong Deviation

The d-Enantiomer Form of Indobufen Totally Accounts for the Anti-Cyclooxygenase and Antiplatelet Activity Ex Vivo and for the Increase in Bleeding Time by Indobufen in Man

1992 ◽  
Vol 67 (02) ◽  
pp. 258-263 ◽  
Author(s):  
Raffaele De Caterina ◽  
Rosa Sicari ◽  
An Yan ◽  
Walter Bernini ◽  
Daniela Giannessi ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Platelet Aggregation ◽  
Plasma Levels ◽  
Bleeding Time ◽  
Ex Vivo ◽  
Random Sequence ◽  
Antiplatelet Agent ◽  
Antiplatelet Drug ◽  
Double Blind

SummaryIndobufen is an antiplatelet drug able to inhibit thromboxane production and cyclooxygenase-dependent platelet aggregation by a reversible inhibition of cyclooxygenase. Indobufen exists in two enantiomeric forms, of which only d-indobufen is active in vitro in inhibiting cyclooxygenase. In order to verify that also inhibition of platelet function is totally accounted for by d-indobufen, ten patients with proven coronary artery disease (8 male, 2 female, age, mean ± S.D., 58.7 ± 7.5 years) were given, in random sequence, both 100 mg d-indobufen and 200 mg dl-indobufen as single administrations in a double-blind crossover design study with a washout period between treatments of 72 h. In all patients thromboxane (TX) B2 generation after spontaneous clotting (at 0, 1, 2, 4, 6, 8, 12, 24 h), drug plasma levels (at the same times), platelet aggregation in response to ADP, adrenaline, arachidonic acid, collagen, PAF, and bleeding time (at 0, 2, 12 h) were evaluated after each treatment. Both treatments determined peak inhibition of TXB2 production at 2 h from administration, with no statistical difference between the two treatments (97 ±3% for both treatments). At 12 h inhibition was 87 ± 6% for d-indobufen and 88 ± 6% for dl-indobufen (p = NS). Inhibition of TXB2 production correlated significantly with plasma levels of the drugs. Maximum inhibitory effect on aggregation was seen in response to collagen 1.5 pg/ml (63 ± 44% for d-indobufen and 81 ± 22% for dl-indobufen) and arachidonic acid 0.5-2 mM (78 ± 34% for d-indobufen and 88 ± 24% for dl-indobufen) at 2 h after each administration. An effect of both treatments on platelet aggregation after 12 h was present only for adrenaline 2 μM (55 ± 41% for d-indobufen and 37 ± 54% for dl-indobufen), collagen 1.5 pg/ml (69 ± 30% for d-indobufen and 51 ± 61% for dl-indobufen), arachidonic acid 0.5-2 mM (56 ± 48% for d-indobufen and 35 ± 49% for dl-indobufen). The extent of inhibition of TX production and the extent of residual platelet aggregation were never significantly different between treatments. Bleeding time prolongation was similar in the two treatment groups without showing a pronounced and long lasting effect (from 7.0 ± 2.0 min to 10.0 ± 3.0 min at 2 h and 8.0 ± 2.0 min at 12 h for d-indobufen; from 6.0 ±1.0 min to 8.5 ± 2.0 min at 2 h and 8.0 ± 1.0 min at 12 h for dl-indobufen). These results demonstrate that the biological activity of dl-indobufen as an antiplatelet agent in vivo is totally accounted for by d-indobufen.

Validation of a monetary Taylor Aggression Paradigm: Associations with trait aggression and role of provocation sequence

2020 ◽  
Author(s):  
J Konzok ◽  
L Kreuzpointner ◽  
GI Henze ◽  
L Wagels ◽  
C Kärgel ◽  
...  
Keyword(s):  
Random Sequence ◽  
Reactive Aggression ◽  
Reaction Time Task ◽  
Competitive Reaction ◽  
Experimental Conditions ◽  
Fixed Sequence ◽  
Taylor Aggression Paradigm ◽  
Trait Aggression ◽  
Significant Difference ◽  
In Series

© 2020 Elsevier Inc. The Taylor Aggression Paradigm (TAP) is widely used to measure reactive aggression in laboratory settings. While modified versions (mTAPs) with various stimulus characteristics (shocks, noise, pressure, heat) have already been established, a modified version with monetary stimuli has only been introduced very recently. In this experiment, 209 young healthy participants (104 males, 105 females) completed a mock Competitive Reaction Time Task (CRTT) with a fictional opponent with preprogrammed 40 win and 60 lose trials. In lose trials, participants were provoked by subtracting a low (0–20 euro cents), medium (30–60 cents) or high (70–90 cents) amount of money from their fictitious account. Provocation stimuli were either presented randomly or in a fixed sequence (experimental conditions). In contrast to a random sequence, the fixed sequence was generated by repeating trials from the same provocation category in series of three. Linear mixed models (LMMs) considering aggression trajectories revealed significant effects of provocation (low, medium, high) and trait aggression (K-FAF) on reactive aggression. Men showed significantly higher reactive aggression levels than women. In regard to provocation sequence, we found no significant difference in reactive aggression between the random vs. fixed stimulus sequences. The findings provide new evidence supporting the view that the monetary mTAP is able to induce as well as capture reactive aggression in the laboratory. Additionally, we found no advantage of a fixed sequence as the level of reactive aggression in a given trial appeared to be mainly predicted by the preceding provocation trial.

Modeling a random sequence of extremes of loads for fatigue tests under irregular loading

2020 ◽  
pp. 13-19
Author(s):  
N.A. Mahutov ◽  
I.V. Gadolina ◽  
S.G. Lebedinskiy ◽  
E.S. Oganyan ◽  
A.A. Bautin
Keyword(s):  
Random Sequence ◽  
Fatigue Tests ◽  
Linear Hypothesis ◽  
Resource Estimation ◽  
Transition Matrices ◽  
Random Loading ◽  
Markov Transition ◽  
Random Nature ◽  
Irregular Loading ◽  
Markov Transition Matrices

Methods and approaches to tests under random loading are considered, their role is characterized. To ensure the random nature of loading, a modeling method based on Markov transition matrices and real processes recorded in operation is proposed. Keywords: random loading process, Markov repetition matrices, resource estimation, corrected linear hypothesis, parameter of completeness of the loading spectrum. [email protected]

scholarly journals Epistatic Control of Non-Mendelian Inheritance in Mouse Interspecific Crosses

Genetics ◽  
1996 ◽  
Vol 143 (4) ◽  
pp. 1739-1752 ◽  
Author(s):  
Xavier Montagutelli ◽  
Rowena Turner ◽  
Joseph H Nadeau
Keyword(s):  
X Chromosome ◽  
Genetic Basis ◽  
Mendelian Inheritance ◽  
The Other ◽  
Interspecific Crosses ◽  
Chromosome 2 ◽  
Mus Spretus ◽  
F1 Hybrid ◽  
Strong Deviation ◽  
Marker Loci

Abstract Strong deviation of allele frequencies from Mendelian inheritance favoring Mus spretus-derived alleles has been described previously for X-linked loci in four mouse interspecific crosses. We reanalyzed data for three of these crosses focusing on the location of the gene(s) controlling deviation on the X chromosome and the genetic basis for incomplete deviation. At least two loci control deviation on the X chromosome, one near Xist (the candidate gene controlling X inactivation) and the other more centromerically located. In all three crosses, strong epistasis was found between loci near Xist and marker loci on the central portion of chromosome 2. The mechanism for this deviation from Mendelian expectations is not yet known but it is probably based on lethality of embryos carrying particular combinations of alleles rather than true segregation distortion during oogenesis in F1 hybrid females.

scholarly journals Security Analysis and Improvement of an Image Encryption Cryptosystem Based on Bit Plane Extraction and Multi Chaos

Entropy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. 505
Author(s):  
Shuqin Zhu ◽  
Congxu Zhu
Keyword(s):  
Image Encryption ◽  
Random Sequence ◽  
Security Analysis ◽  
Encryption Algorithm ◽  
Original Algorithm ◽  
Plane Extraction ◽  
Bit Plane ◽  
Bit Planes ◽  
And Diffusion ◽  
Improved Algorithm

This paper analyzes the security of image encryption systems based on bit plane extraction and multi chaos. It includes a bit-level permutation for high, 4-bit planes and bit-wise XOR diffusion, and finds that the key streams in the permutation and diffusion phases are independent of the plaintext image. Therefore, the equivalent diffusion key and the equivalent permutation key can be recovered by the chosen-plaintext attack method, in which only two special plaintext images and their corresponding cipher images are used. The effectiveness and feasibility of the proposed attack algorithm is verified by a MATLAB 2015b simulation. In the experiment, all the key streams in the original algorithm are cracked through two special plaintext images and their corresponding ciphertext images. In addition, an improved algorithm is proposed. In the improved algorithm, the generation of a random sequence is related to ciphertext, which makes the encryption algorithm have the encryption effect of a “one time pad”. The encryption effect of the improved algorithm is better than that of the original encryption algorithm in the aspects of information entropy, ciphertext correlation analysis and ciphertext sensitivity analysis.

scholarly journals Coexisting Attractors and Multistability in a Simple Memristive Wien-Bridge Chaotic Circuit

Entropy ◽  
2019 ◽  
Vol 21 (7) ◽  
pp. 678 ◽  
Author(s):  
Yixuan Song ◽  
Fang Yuan ◽  
Yuxia Li
Keyword(s):  
Chaotic System ◽  
Analog Circuit ◽  
Random Sequence ◽  
Mathematical Expression ◽  
Digital Signal ◽  
Approximate Entropy ◽  
Chaotic Circuit ◽  
Coexisting Attractors ◽  
Key Space ◽  
Sequence Generator

In this paper, a new voltage-controlled memristor is presented. The mathematical expression of this memristor has an absolute value term, so it is called an absolute voltage-controlled memristor. The proposed memristor is locally active, which is proved by its DC V–I (Voltage–Current) plot. A simple three-order Wien-bridge chaotic circuit without inductor is constructed on the basis of the presented memristor. The dynamical behaviors of the simple chaotic system are analyzed in this paper. The main properties of this system are coexisting attractors and multistability. Furthermore, an analog circuit of this chaotic system is realized by the Multisim software. The multistability of the proposed system can enlarge the key space in encryption, which makes the encryption effect better. Therefore, the proposed chaotic system can be used as a pseudo-random sequence generator to provide key sequences for digital encryption systems. Thus, the chaotic system is discretized and implemented by Digital Signal Processing (DSP) technology. The National Institute of Standards and Technology (NIST) test and Approximate Entropy analysis of the proposed chaotic system are conducted in this paper.

Une nouvelle méthode de mesure de la fonction d'aire du conduit vocal : cas des voyelles

2005 ◽  
Vol 83 (7) ◽  
pp. 721-737
Author(s):  
H Teffahi ◽  
B Guerin ◽  
A Djeradi
Keyword(s):  
Measurement Method ◽  
Cross Correlation ◽  
Sound Production ◽  
Linear Prediction ◽  
Vocal Tract ◽  
Random Sequence ◽  
Speech Sound ◽  
Acoustic Properties ◽  
External Excitation ◽  
White Noise Excitation

Knowledge of vocal tract area functions is important for the understanding of phenomena occurring during speech production. We present here a new measurement method based on the external excitation of the vocal tract with a known pseudo-random sequence, where the area function is obtained by a linear prediction analysis applied to the cross-correlation between the sequence and the signal measured at the lips. The advantages of this method over methods based on sweep-tones or white noise excitation are (1) a much shorter measurement time (about 100 ms) and (2) the possibility of speech sound production during the measurement. This method has been checked against classical methods through systematic comparisons on a small corpus of vowels. Moreover, it has been verified that simultaneous speech sound production does not perturb significantly the measurements. This method should thus be a very helpful tool for the investigation of the acoustic properties of the vocal tract in various cases for vowels.

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