Sustained release formulation of Ondansetron HCl using osmotic drug delivery approach

2020 ◽  
Vol 46 (3) ◽  
pp. 343-355
Author(s):  
Ramakant Gundu ◽  
Sanjay Pekamwar ◽  
Santosh Shelke ◽  
Santosh Shep ◽  
Deepak Kulkarni
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Delivery Approach

scholarly journals Formulation and evaluation of bilayer tablets: Glimepiride in floating drug delivery and Metformin in sustained release

2019 ◽  
Vol 10 (3) ◽  
pp. 1602-1607
Author(s):  
Harish Choodappa ◽  
Subramanian Somaskandan
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Guar Gum ◽  
Release Kinetics ◽  
Dose Frequency ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Bilayer Tablets ◽  
Weight Variation ◽  
Floating Drug Delivery

In this study, we aimed to prepare bilayer tablets of Glimepiride in floating drug delivery and Metformin in sustained release formulation. Glimepiride is chosen in floating drug delivery to overcome the gastric irritation and gastric emptying time. Glimepiride was prepared by different polymers such as guar gum, xanthan gum, carbopol and sodium bicarbonate act as effervescent agent, and other excipients were mixed and compressed by direct compression as the first layer.  Metformin was chosen in sustained release to reduce dose frequency using different polymer HPMC K100M, methylcellulose, PVP K30 in different ratio and other excipients were mixed and compressed as the second layer. The first layer and second layer are combined as a bilayer tablet. Tablets were evaluated for hardness, friability, thickness, weight variation; the In vitro studies were done for all formulation. Among all formulation, F2 was selected as best formulation and release kinetics studies were evaluated for formulation F2.

▾ Piretanide for hypertension

1985 ◽  
Vol 23 (11) ◽  
pp. 43-44
Keyword(s):  
Glucose Tolerance ◽  
Sustained Release ◽  
Loop Diuretic ◽  
Plasma Potassium ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Treatment Of Hypertension

Piretanide is a loop diuretic recently marketed in a sustained-release formulation (Arelix - Hoechst) solely for the treatment of hypertension (rather than as a general diuretic). The manufacturer claims that piretanide has several advantages over the thiazides, including little or no effect on plasma potassium and magnesium, and no impairment of glucose tolerance.

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