Dietary Magnesium Deficiency Induces Heart Rhythm Changes, Impairs Glucose Tolerance, and Decreases Serum Cholesterol in Post Menopausal Women

2007 ◽  
Vol 26 (2) ◽  
pp. 121-132 ◽  
Author(s):  
Forrest H. Nielsen ◽  
David B. Milne ◽  
Leslie M. Klevay ◽  
Sandra Gallagher ◽  
LuAnn Johnson
Keyword(s):  
Glucose Tolerance ◽  
Serum Cholesterol ◽  
Magnesium Deficiency ◽  
Heart Rhythm ◽  
Menopausal Women ◽  
Dietary Magnesium ◽  
Post Menopausal

FURTHER CYTOLOGICAL OBSERVATIONS CONCERNING OESTROGENIC ACTIVITY IN POST-MENOPAUSAL WOMEN

1961 ◽  
Vol 38 (4) ◽  
pp. 515-526 ◽  
Author(s):  
F. de Waard ◽  
E. A. Baanders-van Halewijn
Keyword(s):  
Glucose Tolerance ◽  
Endometrial Carcinoma ◽  
Postmenopausal Women ◽  
Urinary Sediment ◽  
Body Build ◽  
Menopausal Women ◽  
Obesity Hypertension ◽  
Post Menopausal

ABSTRACT The occurrence of oestrogenic activity in cytological preparations of postmenopausal women in apparent health has been studied using urinary sediment smears. Postmenopausal oestrus is found to be associated with obesity, hypertension and probably also with decreased glucose tolerance. It seems to have a hereditary tendency in which body build is involved. The oestrogens causing the cytological effects are of adrenal origin. Some criticism is advanced against the hypothesis of Galli Mainini et al. (1956) and Castellanos & Sturgis (1958) as regards a cytological index specific of adrenal oestrogens. Some findings relevant to the genesis of endometrial carcinoma are discussed.

METABOLIC AND HORMONAL EFFECTS OF POST-MENOPAUSAL OESTROGEN REPLACEMENT TREATMENT

1977 ◽  
Vol 86 (3) ◽  
pp. 583-596 ◽  
Author(s):  
Ulf Larsson-Cohn ◽  
Lars Wallentin
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Significant Deterioration ◽  
Insulin Levels ◽  
Replacement Treatment ◽  
Menopausal Women ◽  
Oral Glucose Tolerance Tests ◽  
Glucose Tolerance Tests ◽  
Post Menopausal

ABSTRACT Glucose, insulin and growth hormone (GH) levels were measured during 3 h oral glucose tolerance tests, performed in two groups of post-menopausal women. Nineteen subjects were given ethinyloestradiol (EOe) 0.05 mg daily and 20 received oestradiol valerianate (OeV) 2 mg daily. The tests were performed twice before treatment and after 1, 3 and 6 cycles of medication. EOe induced a slight but statistically significant deterioration of the glucose tolerance concomitant with a tendency to elevated insulin levels. The women taking OeV showed no significant alteration of the glucose or insulin levels. The GH concentrations were increased in both groups although the elevation was more pronounced in those taking EOe. The reduced carbohydrate tolerance was not believed to have been responsible for the raised GH levels.

scholarly journals INTERRELATIONSHIPS BETWEEN EXPERIMENTAL HYPERCHOLESTEREMIA, MAGNESIUM REQUIREMENT, AND EXPERIMENTAL ATHEROSCLEROSIS

1957 ◽  
Vol 106 (5) ◽  
pp. 757-766 ◽  
Author(s):  
J. J. Vitale ◽  
P. L. White ◽  
M. Nakamura ◽  
D. M. Hegsted ◽  
N. Zamcheck ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Heart Valves ◽  
Magnesium Deficiency ◽  
Serum Magnesium ◽  
Experimental Atherosclerosis ◽  
Atherogenic Diet ◽  
Calcium Deposition ◽  
Clear Cut ◽  
Dietary Magnesium ◽  
Kidney Lesions

The addition of cholesterol and cholic acid to a diet containing 24 mg. percent of magnesium, an amount normally required for young rats, resulted in magnesium deficiency in rats. This was characterized by hyperexcitability, hyperemia of the ears, calcium deposition in the kidney tubules, low serum magnesium levels, and decreased oxidative phosphorylation of heart mitochondria. All these lesions were prevented by raising the dietary magnesium level four to eight times. Feeding the atherogenic diet produced the deposition of lipide in the aorta and in the heart valves. The extent of this intimal sudanophilia was reduced by large amounts of dietary magnesium although serum cholesterol values did not fall and usually rose. This represents perhaps the first clear cut disassociation between serum cholesterol values and the extent of intimal sudanophilia. Raising the level of dietary protein from 10 to 20 per cent decreased the serum cholesterol levels and the extent of the kidney lesions. Thyroxine administration lowered the serum cholesterol values, abolished the kidney lesions and reduced the intimal sudanophilia. These effects occurred even though the serum magnesium levels remained low.

CORRELATION OF SERUM CHOLESTEROL AND BONE MINERAL DENSITY IN POST MENOPAUSAL WOMEN

2021 ◽  
Vol 5 (12) ◽  
Author(s):  
Sawai Singh ◽  
Lokesh Soni
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Cholesterol Level ◽  
Bone Mineral ◽  
Serum Cholesterol ◽  
Mineral Density ◽  
Menopausal Women ◽  
The Mean ◽  
Group Ii ◽  
Post Menopausal

Background: To find a correlation between serum cholesterol and Bone mineral density in post menopausal women Methods: The study was carried on matched cases and controls. The experimental group consisted of 100 females at postmenopausal age, in which by the DEXA method was diagnosed osteoporosis while the control group consisted of 50 females in a postmenopausal age but without diagnosed osteoporosis who served as controls. Results: Postmenopausal women in the BMI range 18.5 to 25 (normal)were only included in the study. Others were excluded from the study to avoid confounding factors. The mean BMI in women with osteoporosis was 22.13±1.76 and in Group-II was 21.26±2.06. The results were statistically insignificant. Analyzing the average values of serum cholesterol in our study,we found that the mean cholesterol level in group-I was 210.32 ±34.21 mg/dl and 183.21 ±56.32 mg/dl in group-II. The mean cholesterol level was significantly higher in women with osteoporosis. Conclusion: On the decrease in bone mineral density and osteoporosis in postmenopausal women influence many risk factors. Preventive strategies for development of osteoporosis should be initiated in women with elevated serum cholesterol levels. Keywords: Osteoporosis, Menopause, Lipid Profile, BMI.

scholarly journals Eicosanoid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholesterolaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components

2001 ◽  
Vol 85 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Pilar Oubiña ◽  
Francisco J. Sánchez-Muniz ◽  
Sofía Ródenas ◽  
Carmen Cuesta
Keyword(s):  
Oleic Acid ◽  
Cholesterol Level ◽  
Serum Cholesterol ◽  
Serum Cholesterol Level ◽  
Platelet Rich Plasma ◽  
Virgin Olive Oil ◽  
Eicosanoid Production ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Dietary Oil

The present paper compares the effects of two monounsaturated oils, extra virgin olive oil (EVOO) and high-oleic acid sunflower oil (HOSO), on serum and LDL peroxides, eicosanoid production and the thrombogenic ratio (thromboxane (TX) B2:6-keto-prostaglandin F1α) in fourteen non-obese post-menopausal women. The subjects, mean age 63 (SD 11) years, were assigned to two consecutive oleic acid-rich 28 d dietary periods. EVOO and HOSO represented 62 % of the total lipid intake and were used as the only culinary fat during the first and second dietary periods respectively. Serum peroxides, plasma α-tocopherol and TXB2 levels in stimulated platelet-rich plasma (PRP-TXB2) were significantly higher (P<0.01, P<0.001, and P<0.05 respectively) after the HOSO diet than after the EVOO diet. The relationship between the serum cholesterol level (<6.21 mmol/l or ≥6.21 mmol/l) and the type of dietary oil on eicosanoids, peroxides and α-tocopherol were evaluated by two-way ANOVA. Dietary oil significantly affected (P<0.05) the PRP-TXB2 level, whereas serum and LDL peroxides were significantly affected (P<0.001 and P<0.01 respectively) by the serum cholesterol level. The plasma α-tocopherol level was significantly affected by the serum cholesterol level and the type of dietary oil (both P<0.001). No significant relationships were found between serum cholesterol levels, serum peroxide or LDL peroxide levels, plasma α-tocopherol concentrations or α-tocopherol intakes with eicosanoid production or the thrombogenic ratio due to dietary changes. However, in spite of their higher α-tocopherol levels, hypercholesterolaemic subjects showed increased peroxidation in serum and LDL in comparison with normocholesterolaemic subjects on the HOSO diet in comparison with the EVOO diet. These findings suggest that differences in the type of minor compounds, as well as in the concentration of linoleic acid, in both these monounsaturated oils may play an important role in modulating eicosanoid production and lipoprotein peroxidation when they constitute a large proportion of the diet of post-menopausal women.

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