Identification of potential soluble epoxide hydrolase (sEH) inhibitors by ligand-based pharmacophore model and biological evaluation

2019 ◽  
Vol 38 (16) ◽  
pp. 4956-4966 ◽  
Author(s):  
Sudha Bhagwati ◽  
Mohammad Imran Siddiqi
Keyword(s):  
Epoxide Hydrolase ◽  
Pharmacophore Model ◽  
Soluble Epoxide Hydrolase ◽  
Biological Evaluation

scholarly journals Synthesis and biological evaluation of soluble epoxide hydrolase (sEH) inhibitors: t‐AUCB and its derivatives

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
SUNG HEE HWANG ◽  
Hsing‐Ju Tsai ◽  
Christophe Morisseau ◽  
Jun‐Yan Liu ◽  
Bruce D. Hammock
Keyword(s):  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Novel soluble epoxide hydrolase inhibitors with a dihydropyrimidinone scaffold: design, synthesis and biological evaluation

MedChemComm ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 2128-2135 ◽  
Author(s):  
Elham Rezaee ◽  
Mahdi Hedayati ◽  
Laleh Hoghooghi Rad ◽  
Soraya Shahhosseini ◽  
Mehrdad Faizi ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Biological Evaluation ◽  
Scaffold Design ◽  
Urea Derivatives ◽  
Design Synthesis ◽  
Soluble Epoxide Hydrolase Inhibitors ◽  
Synthesis And Biological Evaluation

Amide non-urea derivatives with a dihydropyrimidinone ring as a novel secondary pharmacophore against the sEH enzyme were designed, synthesized and biologically evaluated.

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