Diterpene Sonderianin isolated from Croton blanchetianus exhibits acetylcholinesterase inhibitory action and anxiolytic effect in adult zebrafish (Danio rerio) by 5-HT system

2021 ◽  
pp. 1-16
Author(s):  
Joyce dos Reis Lima ◽  
Maria Kueirislene Amancio Ferreira ◽  
Ketelly Vanessa Barros Sales ◽  
Antônio Wlisses da Silva ◽  
Emanuelle Machado Marinho ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Inhibitory Action ◽  
Anxiolytic Effect ◽  
Adult Zebrafish

scholarly journals Anxiolytic-like and Anticonvulsant Effect in Adult Zebrafish (Danio rerio) through GABAergic System and Molecular Docking Study of Chalcone Derived from Natural Products

2021 ◽  
Vol 11 (6) ◽  
pp. 14021-14031
Keyword(s):  
Danio Rerio ◽  
Motor Coordination ◽  
Anxiolytic Effect ◽  
Docking Study ◽  
Term Treatment ◽  
Gabaergic System ◽  
Anticonvulsant Effect ◽  
Adult Zebrafish ◽  
Molecular Docking Study ◽  
Long Term Treatment

Anxiety and seizure are mental disorders commonly treated in the clinic with benzodiazepines (BZDs). However, long-term treatment with these drugs causes side effects such as decreased motor coordination, drowsiness, sedation, and, when used for a long time, leads to dependence and withdrawal syndromes. This study's objective was to evaluate the anxiolytic-like and anticonvulsant effect in adult zebrafish (Danio rerio) through GABAergic system of synthetic chalcone derived from cinnamaldehyde and natural acetophenone isolated from Croton anisodontus and their mechanisms of action via the Gabaergic system, using adult zebrafish. The animals were treated with chalcone (0.1 or 0.5 or 1.0 mg / kg; 20 µL; i.p;) and subjected to the open field test. The chalcone caused locomotor alteration when evaluated in the light & dark anxiolytic test. The lowest effective dose was chosen to assess possible involvement in the GABAA receptor. The chalcone showed anxiolytic and anticonvulsant effects in all doses in both tests. The chalcone presented anticonvulsant activity, a possible inhibitor of Carbonic Anhydrase and an anxiolytic effect dependent on the GABAergic system, coupling it in a different region from the diazepam inhibitor.

Axonal projections originating from raphe serotonergic neurons in the developing and adult zebrafish,Danio rerio, using transgenics to visualize raphe-specificpet1expression

2009 ◽  
Vol 512 (2) ◽  
pp. 158-182 ◽  
Author(s):  
Christina Lillesaar ◽  
Christian Stigloher ◽  
Birgit Tannhäuser ◽  
Mario F. Wullimann ◽  
Laure Bally-Cuif
Keyword(s):  
Danio Rerio ◽  
Adult Zebrafish ◽  
Serotonergic Neurons ◽  
Axonal Projections

scholarly journals Different action mechanisms of low- and high-level quercetin in the brains of adult zebrafish (Danio rerio)

2021 ◽  
Vol 223 ◽  
pp. 112597
Author(s):  
Xia Wu ◽  
Li-Jun Wang ◽  
Yu Hou ◽  
Rui-Ying Guo ◽  
Min Liu ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Adult Zebrafish ◽  
Action Mechanisms ◽  
High Level

scholarly journals Distribution of carnosine-like peptides in the nervous system of developing and adult zebrafish (Danio rerio) and embryonic effects of chronic carnosine exposure

2009 ◽  
Vol 337 (1) ◽  
pp. 45-61 ◽  
Author(s):  
Marie-Claude Senut ◽  
Seema Azher ◽  
Frank L. Margolis ◽  
Kamakshi Patel ◽  
Ahmad Mousa ◽  
...  
Keyword(s):  
Nervous System ◽  
Danio Rerio ◽  
Adult Zebrafish

scholarly journals Evaluation of non‐clinical safety of Frutalin in adult Zebrafish ( Danio rerio )

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Ana Cristina Oliveira Monteiro‐Moreira ◽  
Antônio Eufrásio Vieira‐Neto ◽  
Maria Kueirislene Amâncio Ferreira ◽  
Francisco Rogênio Silva Mendes ◽  
Adriana Rolim Campos Barros ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Adult Zebrafish ◽  
Clinical Safety

Calocybe indicia extract modifies GABA and Serotonin levels to Alleviate anxiety in experimental adult Zebrafish models

2021 ◽  
pp. 4789-4794
Author(s):  
Sarah Andrea Wilson ◽  
Anushree Nagaraj ◽  
Lalitha Vaidyanathan
Keyword(s):  
Biochemical Parameters ◽  
Anxiolytic Effect ◽  
The Novel ◽  
Adult Zebrafish ◽  
Tissue Weight ◽  
Mao A ◽  
Before And After ◽  
Tank Test ◽  
Gaba Content ◽  
Calocybe Indica

Zebrafish (Danio rerio) was used as a model to study anxiety due to its physiological homology to humans. The pathophysiology of anxiety, even though still unclear, has been extensively studied in Zebrafish. Anxiety was induced by withdrawal after exposure to 0.5% ethanol, which proved to be anxiogenic, validated through the novel tank test. The light/dark test revealed that exposure to 0.5% ethanol had anxiolytic effects. The milky mushroom, Calocybe indica was used to treat anxiety since its anti-hypertensive effects have already been reported. Biochemical parameters such as GABA and MAO (A&B) were measured before and after treatment with different concentrations of C. indica and standard anxiolytic drug, Fluoxetine to compare and confirm the anxiolytic effect. The GABA content was found to be 119.9±1.99 mmoles/g tissue weight after treatment with 50 µg C. indica which was comparable to the normal group values (100±4.12). MAO (A&B) activity decreased which in turn increased serotonin levels with 25µg of C. indica. 25µg and 100µg concentration of the extract of C. indica was found to be optimum in reducing the level of anxiety.

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