The Immunomodulatory Activity of C3 Binding Glycoprotein (C3bgp) is Mediated by the Complement Receptor Type III and Mitogen-Activated Protein Kinase Signal Transduction Pathways

2007 ◽  
Vol 29 (3-4) ◽  
pp. 549-562 ◽  
Author(s):  
Zlatka Georgieva Dobreva ◽  
Spaska Angelova Stanilova
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Receptor Type ◽  
Signal Transduction Pathways ◽  
Immunomodulatory Activity ◽  
Complement Receptor ◽  
Complement Receptor Type ◽  
Mitogen Activated Protein ◽  
Binding Glycoprotein

scholarly journals Protein Kinase A and Mitogen-Activated Protein Kinase Pathways Antagonistically Regulate Fission Yeast fbp1Transcription by Employing Different Modes of Action at Two Upstream Activation Sites

2000 ◽  
Vol 20 (17) ◽  
pp. 6426-6434 ◽  
Author(s):  
Lori A. Neely ◽  
Charles S. Hoffman
Keyword(s):  
Signal Transduction ◽  
Transcriptional Regulation ◽  
Protein Kinase ◽  
Mapk Pathway ◽  
Transcriptional Start Site ◽  
Mitogen Activated Protein Kinase ◽  
Signal Transduction Pathways ◽  
Start Site ◽  
Mitogen Activated Protein ◽  
Kinase A

ABSTRACT A significant challenge to our understanding of eukaryotic transcriptional regulation is to determine how multiple signal transduction pathways converge on a single promoter to regulate transcription in divergent fashions. To study this, we have investigated the transcriptional regulation of theSchizosaccharomyces pombe fbp1 gene that is repressed by a cyclic AMP (cAMP)-dependent protein kinase A (PKA) pathway and is activated by a stress-activated mitogen-activated protein kinase (MAPK) pathway. In this study, we identified and characterized twocis-acting elements in the fbp1 promoter required for activation of fbp1 transcription. Upstream activation site 1 (UAS1), located approximately 900 bp from the transcriptional start site, resembles a cAMP response element (CRE) that is the binding site for the atf1-pcr1 heterodimeric transcriptional activator. Binding of this activator to UAS1 is positively regulated by the MAPK pathway and negatively regulated by PKA. UAS2, located approximately 250 bp from the transcriptional start site, resembles a Saccharomyces cerevisiae stress response element. UAS2 is bound by transcriptional activators and repressors regulated by both the PKA and MAPK pathways, although atf1 itself is not present in these complexes. Transcriptional regulation offbp1 promoter constructs containing only UAS1 or UAS2 confirms that the PKA and MAPK regulation is targeted to both sites. We conclude that the PKA and MAPK signal transduction pathways regulatefbp1 transcription at UAS1 and UAS2, but that the antagonistic interactions between these pathways involve different mechanisms at each site.

EXTRAOCULAR CELLULAR PHOTOTRANSDUCTION

2009 ◽  
Vol 02 (01) ◽  
pp. 93-100 ◽  
Author(s):  
LING ZHU ◽  
TIMON CHENG-YI LIU ◽  
MIN WU ◽  
JIAN-QIN YUAN ◽  
TONG-SHENG CHEN
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Monochromatic Light ◽  
Mitogen Activated Protein Kinase ◽  
Signal Transduction Pathways ◽  
Mitogen Activated Protein ◽  
Cellular Signal ◽  
Gs Protein ◽  
Almost All ◽  
Relationship Of

Photobiomodulation (PBM) is a modulation of monochromatic light or laser irradiation (LI) on biosystems. It is reviewed from the viewpoint of extraocular phototransduction in this paper. It was found that LI can induce extraocular phototransduction, and there may be an exact correspondence relationship of LI at different wavelengths and in different dose zones, and cellular signal transduction pathways. The signal transduction pathways can be classified into two types so that the Gs protein-mediated pathways belong to pathway 1, and the other pathways such as protein kinase Cs -mediated pathways and mitogen-activated protein kinase-mediated pathways belong to pathway 2. Almost all the present pathways found to mediate PBM belong to pathway 2, but there should be a pathway 1-mediated PBM. The previous studies were rather preliminary, and therefore further work should be done.

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

2001 ◽  
Vol 81 (2) ◽  
pp. 807-869 ◽  
Author(s):  
John M. Kyriakis ◽  
Joseph Avruch
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Treatment Strategies ◽  
Nuclear Factor Κb ◽  
Mitogen Activated Protein Kinase ◽  
Signal Transduction Pathways ◽  
Mitogen Activated Protein ◽  
Novel Treatment Strategies ◽  
Care Problems ◽  
The Impact

The molecular details of mammalian stress-activated signal transduction pathways have only begun to be dissected. This, despite the fact that the impact of these pathways on the pathology of chronic inflammation, heart disease, stroke, the debilitating effects of diabetes mellitus, and the side effects of cancer therapy, not to mention embryonic development, innate and acquired immunity, is profound. Cardiovascular disease and diabetes alone represent the most significant health care problems in the developed world. Thus it is not surprising that understanding these pathways has attracted wide interest, and in the past 10 years, dramatic progress has been made. Accordingly, it is now becoming possible to envisage the transition of these findings to the development of novel treatment strategies. This review focuses on the biochemical components and regulation of mammalian stress-regulated mitogen-activated protein kinase (MAPK) pathways. The nuclear factor-κB pathway, a second stress signaling paradigm, has been the subject of several excellent recent reviews (258, 260).

scholarly journals The Mitogen-Activated Protein Kinase Signal Transduction Pathways in Alternaria Species

2012 ◽  
Vol 28 (3) ◽  
pp. 227-238
Author(s):  
Houjuan Xu ◽  
Xiaoxue Xu ◽  
Yu-Jun Wang ◽  
Vivek K. Bajpai ◽  
Lisha Huang ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Signal Transduction Pathways ◽  
Mitogen Activated Protein ◽  
Alternaria Species
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