Implications of immunotherapy with high-dose glatiramer acetate in acute phase of spinal cord injury in rats

2019 ◽  
Vol 41 (1) ◽  
pp. 150-162 ◽  
Author(s):  
Hadi Askarifirouzjaei ◽  
Leila Khajoueinejad ◽  
Amir Salek Farrokhi ◽  
Mohammad-Taher Tahoori ◽  
Mehdi Fazeli ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glatiramer Acetate ◽  
Acute Phase ◽  
High Dose ◽  
Cord Injury

Spermatogenesis and the Pituitary-Testicular Hormone Axis in Rats During the Acute Phase of Spinal Cord Injury

1994 ◽  
Vol 152 (4) ◽  
pp. 1302-1307 ◽  
Author(s):  
Todd A. Linsenmeyer ◽  
Leonard M. Pogach ◽  
John E. Ottenweller ◽  
Hosea F.S. Huang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Acute Phase ◽  
Cord Injury

scholarly journals Acute phase complications following traumatic spinal cord injury in Dutch level 1 trauma centres

2014 ◽  
Vol 46 (9) ◽  
pp. 882-885 ◽  
Author(s):  
K Weert ◽  
E Schouten ◽  
J Hofstede ◽  
H Meent ◽  
H Holtslag ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Acute Phase ◽  
Traumatic Spinal Cord Injury ◽  
Trauma Centres ◽  
Cord Injury ◽  
Level 1

scholarly journals Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Guodong Sun ◽  
Shenghui Zeng ◽  
Xu Liu ◽  
Haishan Shi ◽  
Renwen Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Central Component ◽  
High Dose ◽  
Interleukin 17 ◽  
Cord Injury

Abstract Acute inflammation is a central component in the progression of spinal cord injury (SCI). Anti-inflammatory drugs used in the clinic are often administered systemically at high doses, which can paradoxically increase inflammation and result in drug toxicity. A cluster-like mesoporous silica/arctigenin/CAQK composite (MSN-FC@ARC-G) drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord. In this nanosystem, mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites. The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier. Arctigenin, a Chinese herbal medicine, was loaded into the nanosystem to reduce inflammation. The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site. Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage, especially reducing the expression of interleukin-17 (IL-17) and IL-17-related inflammatory factors, inhibiting the activation of astrocytes, thus protecting neurons and accelerating the recovery of SCI. Our study demonstrated that this novel, silica-based drug delivery system has promising potential for clinical application in SCI therapy.

scholarly journals High dose compressive loads attenuate bone mineral loss in humans with spinal cord injury

2011 ◽  
Vol 23 (9) ◽  
pp. 2335-2346 ◽  
Author(s):  
S. Dudley-Javoroski ◽  
P. K. Saha ◽  
G. Liang ◽  
C. Li ◽  
Z. Gao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Mineral ◽  
High Dose ◽  
Bone Mineral Loss ◽  
Cord Injury ◽  
Compressive Loads ◽  
Mineral Loss
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