Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway

2021 ◽  
pp. 1-11
Author(s):  
Nageh Ahmed El-Mahdy ◽  
Magda El-Sayed El-Sayad ◽  
Aya Hassan El-Kadem ◽  
Sally EL-Sayed Abu-Risha
Keyword(s):  
Ulcerative Colitis ◽  
Signaling Pathway ◽  
Sphingosine Kinase ◽  
Sphingosine Kinase 1 ◽  
Sphingosine 1 Phosphate

scholarly journals Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin

2016 ◽  
Vol 61 (2) ◽  
pp. 168-176 ◽  
Author(s):  
Irene Crespo ◽  
Beatriz San-Miguel ◽  
Diana I. Sánchez ◽  
Bárbara González-Fernández ◽  
Marcelino Álvarez ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Fulminant Hepatitis ◽  
Sphingosine Kinase ◽  
Sphingosine Kinase 1 ◽  
Viral Origin ◽  
Sphingosine 1 Phosphate

scholarly journals Role of sphingosine kinase 1 and sphingosine‐1‐phosphate in CD40 signaling and IgE class switching

2014 ◽  
Vol 28 (10) ◽  
pp. 4347-4358 ◽  
Author(s):  
Eugene Y. Kim ◽  
Jamie L. Sturgill ◽  
Nitai C. Hait ◽  
Dorit Avni ◽  
Evelyn C. Valencia ◽  
...  
Keyword(s):  
Sphingosine Kinase ◽  
Sphingosine Kinase 1 ◽  
Class Switching ◽  
Sphingosine 1 Phosphate

scholarly journals The Functional Role of Sphingosine Kinase 2

2021 ◽  
Vol 8 ◽  
Author(s):  
Rocio Diaz Escarcega ◽  
Louise D. McCullough ◽  
Andrey S. Tsvetkov
Keyword(s):  
Sphingosine Kinase ◽  
Telomere Maintenance ◽  
Sphingosine Kinase 1 ◽  
Lipid Molecule ◽  
Nuclear Signaling ◽  
Sphingosine Kinase 2 ◽  
Sphingosine 1 Phosphate ◽  
Associated Conditions ◽  
Health And Disease

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and sphingosine kinase 2 (SPHK2), synthesize S1P by phosphorylating sphingosine. While SPHK1 is a cytoplasmic kinase, SPHK2 is localized to the nucleus, endoplasmic reticulum, and mitochondria. The SPHK2/S1P pathway regulates transcription, telomere maintenance, mitochondrial respiration, among many other processes. SPHK2 is under investigation as a target for treating many age-associated conditions, such as cancer, stroke, and neurodegeneration. In this review, we will focus on the role of SPHK2 in health and disease.

scholarly journals The Role of Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in the Myogenic Tone of Posterior Cerebral Arteries

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35177 ◽  
Author(s):  
Mihwa Lim ◽  
Soo-Kyoung Choi ◽  
Young-Eun Cho ◽  
Soo-In Yeon ◽  
Eok-Cheon Kim ◽  
...  
Keyword(s):  
Cerebral Arteries ◽  
Sphingosine Kinase ◽  
Myogenic Tone ◽  
Sphingosine Kinase 1 ◽  
Sphingosine 1 Phosphate
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