Modelling the effect of a GHz electric field on the dynamics of K+ions in KcsA potassium channel

2013 ◽  
Vol 40 (5) ◽  
pp. 399-407 ◽  
Author(s):  
M. Sajadi ◽  
A. Lohrasebi ◽  
H. Rafii-Tabar
Keyword(s):  
Electric Field ◽  
Potassium Channel ◽  
Kcsa Potassium Channel

Surface-enhanced IR absorption spectroscopy of the KcsA potassium channel upon application of an electric field

2015 ◽  
Vol 17 (33) ◽  
pp. 21104-21111 ◽  
Author(s):  
Akira Yamakata ◽  
Hirofumi Shimizu ◽  
Shigetoshi Oiki
Keyword(s):  
Structural Change ◽  
Electric Field ◽  
Potassium Channel ◽  
Absorption Spectroscopy ◽  
Ir Absorption ◽  
Electrochemical System ◽  
Surface Enhanced ◽  
Kcsa Potassium Channel

Surface-enhanced IR absorption spectroscopy coupled with an electrochemical system enables the potassium-induced specific structural change of the potassium channel.

Water molecules response to an external GHz electric field in KcsA potassium channel: A molecular modeling approach

2015 ◽  
Vol 14 (02) ◽  
pp. 1550012 ◽  
Author(s):  
M. Sajadi ◽  
A. Lohrasebi ◽  
S. S. Setayandeh ◽  
H. Rafii-Tabar
Keyword(s):  
Electric Field ◽  
Potassium Channel ◽  
Md Simulation ◽  
Simulation Method ◽  
Cellular Membrane ◽  
Water Molecules ◽  
Potassium Ions ◽  
Dipole Orientation ◽  
Oscillating Electric Field ◽  
Kcsa Potassium Channel

KcsA potassium channel is a membrane protein that allows the passage of potassium ions and water molecules across the cellular membrane. Using molecular dynamics (MD) simulation method, the effect of an applied GHz oscillating electric field of strength 0.004 V/nm on the dynamics of K + and water molecules in a KcsA channel was modeled. It was found that the application of GHz range electric field caused a change in the potential energy profile of the water molecules in the filter sites, causing an increase in the delay time of the water molecules in these sites. Therefore, exposing the channel to the GHz fields can perturb the dynamics of the water molecules in the filter, and consequently, the channel operation may be disturbed. Furthermore, the results show that the applied field has no major effects on the dipole orientation of water molecules in the channel.

Gating-Associated Clustering–Dispersion Dynamics of the KcsA Potassium Channel in a Lipid Membrane

2014 ◽  
Vol 5 (3) ◽  
pp. 578-584 ◽  
Author(s):  
Ayumi Sumino ◽  
Daisuke Yamamoto ◽  
Masayuki Iwamoto ◽  
Takehisa Dewa ◽  
Shigetoshi Oiki
Keyword(s):  
Potassium Channel ◽  
Lipid Membrane ◽  
Kcsa Potassium Channel
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