Characterization of a liposome-based artificial skin membrane for in vitro permeation studies using Franz diffusion cell device

2016 ◽  
Vol 27 (4) ◽  
pp. 302-311 ◽  
Author(s):  
Hui Zhang ◽  
Xuemin Zhu ◽  
Jingjing Shen ◽  
Haiheng Xu ◽  
Min Ma ◽  
...  
Keyword(s):  
Artificial Skin ◽  
Diffusion Cell ◽  
Franz Diffusion Cell ◽  
In Vitro Permeation ◽  
Permeation Studies

scholarly journals Validation of a Static Franz Diffusion Cell System for In Vitro Permeation Studies

2010 ◽  
Vol 11 (3) ◽  
pp. 1432-1441 ◽  
Author(s):  
Shiow-Fern Ng ◽  
Jennifer J. Rouse ◽  
Francis D. Sanderson ◽  
Victor Meidan ◽  
Gillian M. Eccleston
Keyword(s):  
Cell System ◽  
Diffusion Cell ◽  
Franz Diffusion Cell ◽  
In Vitro Permeation ◽  
Permeation Studies

scholarly journals COMPARISON OF EFFECT OF PENETRATION ENHANCER ON DIFFERENT POLYMERS FOR DRUG DELIVERY

2019 ◽  
Vol 11 (1) ◽  
pp. 89
Author(s):  
Bhawana Sethi ◽  
Rupa Mazumder
Keyword(s):  
Oleic Acid ◽  
Permeation Enhancers ◽  
In Vitro Drug Release ◽  
Franz Diffusion Cell ◽  
In Vitro Permeation ◽  
Treatment Of Hypertension ◽  
Permeation Studies ◽  
Evaporation Technique ◽  
Polymer Interaction

Objective: Aliskiren hemifumarate is used for the treatment of hypertension. The aim of this research to study the effect on the delivery of drug using natural and synthetic permeation enhancers like limonene, cineol, β-cyclodextrin, and oleic acid by using different polymers. As different penetration acts differently with polymers.Methods: Transdermal patches were prepared by the solvent evaporation technique. The controlled release polymers were used for the preparation of patches. The patches were prepared with different polymers and different plasticizer. The drug and polymer interaction study was performed by Fourier transform infrared spectra. In vitro permeation studies were conducted using pretreated cellophane membrane using franz diffusion cell. Results: The prepared patches were evaluated for in vitro drug release, and the release profile was varied from 52.32% PGH (oleic acid) to 87.63% B (cineol). The permeability coefficient was found in the range of 5.82 to 8.32 cm/h, and corresponding flux was found between 281.61 to 729.08 µg/cm2/h on the prepared patches and statistical analysis performed using t-test (p<0.005).Conclusion: On the basis of the obtained results, it was concluded that patch prepared using methocel k 15 m as a polymer, glycerin as plasticizer and cineol as a permeation enhancer shows the maximum release. The increase in the release due to increase in the flux.

scholarly journals Development, stability and in vitro permeation studies of gels containing mometasone furoate for the treatment of dermatitis of the scalp

2010 ◽  
Vol 46 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Ana Cristina Gomes Barros Salgado ◽  
Alexandra Maria Nunes Nogueira da Silva ◽  
Marta Cristina Jorge Cabral Machado ◽  
Maria Aida da Silva Costa Duarte ◽  
Helena Margarida de Oliveira Marques Ribeiro
Keyword(s):  
Inflammatory Diseases ◽  
Chemical Characterization ◽  
Mometasone Furoate ◽  
Suitable Alternative ◽  
In Vitro Permeation ◽  
Permeation Studies ◽  
Development Stability ◽  
Microbiological Properties

Dermatological inflammatory diseases such as atopic dermatitis, psoriasis and seborrhoeic dermatitis often affect the scalp and the eyebrows. Although there are many dosage forms available, these are particularly critical anatomic regions for application of topical formulations because of the presence of hair. Lotions are therefore the recommended type of drug delivery system for these areas. The presence of hair may limit the application and thus the acceptability of the formulation and its compliance. Because of its low apparent viscosity, lotion application is unpleasant. Gels, given their consistency and adhesiveness, are a suitable alternative to lotions in this situation. The aim of this study was to formulate a stable gel containing mometasone furoate, which is an anti-inflammatory and anti-pruritic corticosteroid, in order to improve topical treatment of scalp dermatitis. In this study, pharmaceutical development, physical-chemical characterization, stability and in vitro permeation studies were performed. In terms of the pH, viscosity, assay and macroscopic and microbiological properties, the gel was stable over the period of study. The in vitro permeation studies allowed the characterization of the mometasone furoate permeation profile for the gel through different membranes. Mometasone furoate presented a slow permeation through the skin. This gel appears safe for topical application.

scholarly journals Formulation and Evaluation of Ketoprofen Gel Preparations, Sesami Oil Soybean Oil and Oleic Acid as Enhancers

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Rugun Clara Samosir ◽  
Iyan Sopyan ◽  
Dolih Gozali
Keyword(s):  
Oleic Acid ◽  
Soybean Oil ◽  
Sesame Oil ◽  
Drug Formulation ◽  
Diffusion Cell ◽  
Drug Penetration ◽  
Franz Diffusion Cell ◽  
In Vitro Permeation ◽  
Permeation Test

Permeation is a measurable profile in drug penetration in skin. Adding increasing permeation substance (enhancer) in drug formulation is an important thing in pharmaceutical and toxicology in nowadays. The purpose of this research was to evaluate the effect of sesame oil, soybean oil, and oleic acid as enhancer in ketoprofen gel permeation. Six formula were prepared by varying concentration of sesame oil, soybean oil, and oleic acid respectively 5% and 10% and one blank, without enhancer. Permeation test was evaluated by in vitro permeation test using Franz diffusion cell method and shed snake skin of reticulated python as a membrane. Permeation test were carried out for 6 hours. The result showed that sesame oil, soybean oil, and oleic acid were able to increase ketoprofen permeation. B1 formula that contain 5% sesame oil had greatest percent permeation after 6 hours is 5.913%, while blank that contain no enhancer is 0.623%.Keywords: ketoprofen, permeation, enhancer, soybean oil, sesame oil, oleic acid.

Deformable Surfactant Vesicles Loading Ammonium Glycyrrhizinate: Characterization and In Vitro Permeation Studies

2012 ◽  
Vol 9 (5) ◽  
pp. 494-499 ◽  
Author(s):  
Luisa Di Marzio ◽  
Carlotta Marianecci ◽  
Federica Rinaldi ◽  
Sara Esposito ◽  
Maria Carafa
Keyword(s):  
Surfactant Vesicles ◽  
In Vitro Permeation ◽  
Permeation Studies

Development and evaluation of a heparin gel for transdermal delivery via laser-generated micropores

2021 ◽  
Vol 12 (2) ◽  
pp. 133-144
Author(s):  
Deepal Vora ◽  
Yujin Kim ◽  
Ajay K Banga
Keyword(s):  
Transdermal Delivery ◽  
Continuous Intravenous Infusion ◽  
In Vitro Permeation ◽  
Assisted Delivery ◽  
Permeation Studies ◽  
Franz Diffusion Cells ◽  
Transdermal Route ◽  
Poloxamer Gel ◽  
Ablative Laser

Aim: Our study investigated the feasibility of transdermal delivery of heparin, an anticoagulant used against venous thromboembolism, as an alternative to intravenous administration. Materials & methods: Skin was pretreated using ablative laser (Precise Laser Epidermal System [P.L.E.A.S.E.®] technology) for enhanced delivery of heparin. In vitro permeation studies using static Franz diffusion cells provided a comparison between delivery from 0.3% w/v heparin-loaded poloxamer gel and solution across untreated and laser-treated dermatomed porcine ear skin. Results: No passive delivery of heparin was observed. Laser-assisted delivery from solution (26.07 ± 1.82 μg/cm2) was higher (p < 0.05) than delivery from heparin gel (11.28 ± 5.32 μg/cm2). However, gel is likely to sustain the delivery over prolonged periods like a maintenance dose via continuous intravenous infusion. Conclusion: Thus, ablative laser pretreatment successfully delivered heparin, establishing the feasibility of delivering hydrophilic macromolecules using the transdermal route.

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