The role of FGF-4 and FGFR-2 on preimplantation embryo development in experimental maternal diabetes

2021 ◽  
pp. 1-5
Author(s):  
Filiz Yilmaz ◽  
Serap Cilaker Micili ◽  
Guven Erbil
Keyword(s):  
Embryo Development ◽  
Preimplantation Embryo ◽  
Maternal Diabetes ◽  
Preimplantation Embryo Development

Novel Insights on the Role of the Human Sperm Proteome

2020 ◽  
Vol 27 (12) ◽  
pp. 1181-1185
Author(s):  
Rossella Cannarella ◽  
Rosita A. Condorelli ◽  
Aldo E. Calogero ◽  
Sandro La Vignera
Keyword(s):  
Embryo Development ◽  
Preimplantation Embryo ◽  
Male Gamete ◽  
Epigenetic Inheritance ◽  
Human Sperm ◽  
Preimplantation Embryo Development ◽  
Targeted Analysis ◽  
Crucial Information ◽  
Infertile Patients

: The spermatozoon has classically been seen only as a paternal DNA transporter into the oocyte, thus underestimating the entire contribution of the male gamete to the embryo development. The advancement of the research supports that not only the sperm genome, but the entire sperm transcriptome and proteome carry crucial information for fertilization and embryo development. : Altogether, 6871 proteins have been reported in spermatozoa so far. Their functional analysis has recently addressed to the sperm proteome a role in fertilization, preimplantation embryo development and paternal epigenetic inheritance. Targeted analysis of human spermatozoa is warranted to compile an evidence-based list of sperm-carried molecular targets in infertile patients.

scholarly journals Islet transplantation reverses the effects of maternal diabetes on mouse oocytes

Reproduction ◽  
2011 ◽  
Vol 141 (4) ◽  
pp. 417-424 ◽  
Author(s):  
Pan-Pan Cheng ◽  
Jun-Jie Xia ◽  
Hai-Long Wang ◽  
Ji-Bing Chen ◽  
Fei-Yu Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Islet Transplantation ◽  
Embryo Development ◽  
Oocyte Maturation ◽  
Preimplantation Embryo ◽  
Maternal Diabetes ◽  
Meiotic Spindle ◽  
Preimplantation Embryos ◽  
Preimplantation Embryo Development ◽  
Parthenogenetic Activation

Maternal diabetes adversely affects preimplantation embryo development and oocyte maturation. Thus, it is important to identify ways to eliminate the effects of maternal diabetes on preimplantation embryos and oocytes. The objectives of this study were to investigate whether islet transplantation could reverse the effects of diabetes on oocytes. Our results revealed that maternal diabetes induced decreased ovulation; increased the frequency of meiotic spindle defects, chromosome misalignment, and aneuploidy; increased the relative expression levels of Mad2 and Bub1; and enhanced the sensitivity of oocytes to parthenogenetic activation. Islet transplantation prevented these detrimental effects. Therefore, we concluded that islet transplantation could reverse the effects of diabetes on oocytes, and that this technique may be useful to treat the fundamental reproductive problems of women with diabetes mellitus.

scholarly journals Role of Epidermal Growth Factor in Bovine Oocyte Maturation and Preimplantation Embryo Development in Vitro1

1996 ◽  
Vol 54 (6) ◽  
pp. 1420-1429 ◽  
Author(s):  
Pat Lonergan ◽  
Catherine Carolan ◽  
Anne Van Langendonckt ◽  
Isabelle Donnay ◽  
Hadj Khatir ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Embryo Development ◽  
Oocyte Maturation ◽  
Preimplantation Embryo ◽  
Bovine Oocyte ◽  
Preimplantation Embryo Development ◽  
Epidermal Growth
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