Sexual risk behaviour, viral load, and perceptions of HIV transmission among homosexually active Latino men: an exploratory study

AIDS Care ◽  
2005 ◽  
Vol 17 (1) ◽  
pp. 33-45 ◽  
Author(s):  
M. Muñoz-Laboy ◽  
D. Castellanos ◽  
R. Westacott
2017 ◽  
Vol 94 (3) ◽  
pp. 206-211 ◽  
Author(s):  
Michael J Stirratt ◽  
Gary Marks ◽  
Christine O’Daniels ◽  
Edward R Cachay ◽  
Meg Sullivan ◽  
...  

ObjectivesViral load and sexual risk behaviour contribute to HIV transmission risk. High HIV viral loads present greater transmission risk than transient viral ‘blips’ above an undetectable level. This paper therefore characterises sexual risk behaviour among patients with HIV in care with viral loads>1500 copies/mL and associated demographic characteristics.MethodsThis cross-sectional study was conducted at six HIV outpatient clinics in USA. The study sample comprises 1315 patients with HIV with a recent viral load >1500 copies/mL. This study sample was drawn from a larger sample of individuals with a recent viral load >1000 copies/mL who completed a computer-assisted self-interview (CASI) regarding sexual risk practices in the last 2 months. The study sample was 32% heterosexual men, 38% men who have sex with men (MSM) and 30% women.ResultsNinety per cent of the sample had their viral load assay within 60 days of the CASI. Thirty-seven per cent reported being sexually active (vaginal or anal intercourse) in the last 2 months. Most of the sexually active participants reported always using condoms (56.9%) or limiting condomless sex to seroconcordant partners (serosorting; 29.2% overall and 42.9% among MSM). Among sexually active participants who reported condomless anal or vaginal sex with an at-risk partner (14%), most had viral loads>10 000 copies/mL (62%).ConclusionsA relatively small number of patients with HIV in care with viral loads above 1500 copies/mL reported concurrent sexual transmission risk behaviours. Most of the individuals in this small group had markedly elevated viral loads, increasing the probability of transmission. Directing interventions to patients in care with high viral loads and concurrent risk behaviour could strengthen HIV prevention and reduce HIV infections.Trial registration numberNCT02044484, completed.


AIDS ◽  
2004 ◽  
Vol 18 (14) ◽  
pp. 1943-1949 ◽  
Author(s):  
Ineke G Stolte ◽  
John BF de Wit ◽  
Arne van Eeden ◽  
Roel A Coutinho ◽  
Nicole HTM Dukers

2019 ◽  
Author(s):  
Diana M Hendrickx ◽  
Wim Delva ◽  
Niel Hens

AbstractHIV set-point viral load (SPVL) is an important predictor of HIV progression and transmission. Although it has been reported that anti-retroviral therapy (ART) reduces viral load (VL), increased SPVL levels have been observed in MSM in the decade following the introduction of ART in the Netherlands. Several studies have been devoted to explain these counter-intuitive trends in SPVL. However, to our knowledge, none of these studies has investigated an explanation in which it arises as the result of a sexually transmitted infection (STI) co-factor in detail.In this study, we adapted an event-based, individual-based model to investigate how STI co-infection and sexual risk behaviour affect the evolution of HIV SPVL in MSM before and after the introduction of ART.The results suggest that both STI co-factors and sexual risk behaviour have an effect on SPVL. However, the observed trends in SPVL cannot be explained by sexual risk behaviour and STI co-factors only.We recommend to develop mathematical models including also factors related to viral evolution as reported earlier in the literature. However, this requires more complex models, and the collection of more data for parameter estimation than what is currently available.


2018 ◽  
Vol 16 (4) ◽  
pp. 455-462 ◽  
Author(s):  
K. Sherab ◽  
J. Howard ◽  
S. Tshomo ◽  
K. Tshering ◽  
P. Dorji

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