scholarly journals Salivary levels of tumor necrosis factor-α in oral lichen planus

2004 ◽  
Vol 13 (2) ◽  
pp. 131-133 ◽  
Author(s):  
Sonja Pezelj-Ribaric ◽  
Ivana Brekalo Prso ◽  
Maja Abram ◽  
Irena Glazar ◽  
Gordana Brumini ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Lichen Planus ◽  
Tumor Necrosis ◽  
Oral Lichen Planus ◽  
Necrosis Factor Alpha ◽  
Clinical Forms ◽  
Tnf Α ◽  
Whole Saliva ◽  
Oral Lichen ◽  
Necrosis Factor

OBJECTIVE: Oral lichen planus (OLP) is chronic inflammatory disease of the oral mucosa, presenting in various clinical forms. The etiology of OLP is still unknown but mounting evidence points to the immunologic basis of this disorder.Aim: Our study was undertaken to quantify the salivary levels of pro-inflammatory tumor necrosis factor-alpha (TNF-α) in the reticular and the erosive/atrophic forms of OLP, compared with age-matched healthy control volunteers.Subjects and methods: Whole saliva from 40 patients with active lesions of OLP, as well as from 20 healthy persons, was investigated for the presence of TNF-α by enzyme immunoassay.Results: Salivary TNF-α levels were significantlly increased in patients with OLP in comparison with healthy subjects. The presence of TNF-α showed positive correlation to clinical forms of OLP, being significantly higher in the erosive/atrophic type than in the reticular type of disease.Conclusion: Saliva provides an ideal medium for the detection of pro-inflammatory markers of the oral cavity. In patients with OLP, TNF-α levels in saliva are elevated, correlating with the severity of illness. Salivary TNF-α analysis may be a useful diagnostic tool and a potential prognostic marker in OLP.

scholarly journals Association of Oral Lichen Planus and its Treatment on Tumor Necrosis Factor-alpha: A Review Literature and Meta-analysis

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Farzaneh Agha-Hosseini ◽  
Mahdieh Sadat Moosavi ◽  
Nafiseh Sheykhbahaei
Keyword(s):  
Tumor Necrosis Factor ◽  
Lichen Planus ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Oral Lichen Planus ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Oral Lichen ◽  
Necrosis Factor

: Oral lichen planus (OLP) is a relatively common chronic inflammatory disease. The tumor necrosis factor-alpha (TNF-α) is considered as a major mediator in inflammation reactions. No review articles have been done on evaluating TNF-α levels before and after performing standard treatments of OLP so far. This study aimed to provide a complete review on the association between this cytokine and OLP as well as determining the role of therapeutic agents in improving the OLP lesions by measuring the level of this cytokine. Some databases including PubMed, Google Scholar, Scopus, and Embase (Ovid) with keywords of oral lichen planus, Nuclear Factor Kappa B (NF-κB), OLP, TNF-α, and Tumor Necrosis Factor-alpha without time limit (2017 - 1900) were searched to collect the needed data from the related articles. For this purpose, 14 completely related articles were included in this study. Of them, 3 studies that assessed the effect of the standard treatment of oral lichen planus, were included in this meta-analysis. As a result, a significant effect of standard treatment on TNF-α levels in OLP patients has been shown (P-value = 0.02). TNF-α level in OLP patients was higher than in normal subjects, so it can be suggested that the TNF-α levels may be useful in determining prognosis and effectiveness of the treatment performed.

scholarly journals Tumor Necrosis Factor-α and Interferon-γ Polymorphisms Contribute to Susceptibility to Oral Lichen Planus

2004 ◽  
Vol 122 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Marco Carrozzo ◽  
Mariafederica Uboldi de capei ◽  
Ennia Dametto ◽  
Maria Edvige Fasano ◽  
Paolo Arduino ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Lichen Planus ◽  
Tumor Necrosis ◽  
Oral Lichen Planus ◽  
Tumor Necrosis Factor Α ◽  
Interferon Γ ◽  
Factor Α ◽  
Oral Lichen ◽  
Necrosis Factor

Investigation of functional gene polymorphisms interleukin-1β, interleukin-6, interleukin-10 and tumor necrosis factor in individuals with oral lichen planus

2007 ◽  
Vol 36 (8) ◽  
pp. 476-481 ◽  
Author(s):  
Guilherme Machado Xavier ◽  
Alessandra Rosa de Sá ◽  
André Luiz Sena Guimarães ◽  
Tarcília Aparecida da Silva ◽  
Ricardo Santiago Gomez
Keyword(s):  
Tumor Necrosis Factor ◽  
Lichen Planus ◽  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Tumor Necrosis ◽  
Oral Lichen Planus ◽  
Interleukin 10 ◽  
Interleukin 1Β ◽  
Oral Lichen ◽  
Necrosis Factor

scholarly journals Association of tumor necrosis factor-alpha -308 G/A and -238 G/A polymorphism with diabetic retinopathy: a systematic review and updated meta-analysis.

2020 ◽  
Author(s):  
Wenna Gao ◽  
Ruilin Zhu ◽  
liu yang
Keyword(s):  
Diabetic Retinopathy ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Entire Group ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Background: Mounting evidence has suggested tumor necrosis factor-alpha (TNF-α) can promote the development of diabetic retinopathy (DR), and TNF-α gene variants may influence DR risk. However, the results are quite different. Objectives: To comprehensively address this issue, we performed the meta-analysis to evaluate the association of TNF-α-308 G/A and -238 G/A polymorphism with DR. Method: Data were retrieved in a systematic manner and analyzed using STATA Statistical Software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Allelic and genotypic comparisons between cases and controls were evaluated. Results: For the TNF-α-308 G/A polymorphism, overall analysis suggested a marginal association with DR [the OR(95%CI) of (GA versus GG), (GA + AA) versus GG, and (A versus G) are 1.21(1.04, 1.41), 1.20(1.03, 1.39), and 1.14(1.01, 1.30), respectively]. And the subgroup analysis indicated an enhanced association among the European population. For the TNF-α-238 G/A polymorphism, there was mild correlation in the entire group [the OR(95%CI) of (GA versus GG) is 1.55(1.14,2.11) ], which was strengthened among the Asian population. Conclusion: The meta-analysis suggested that -308 A and -238 A allele in TNF-α gene potentially increased DR risk and showed a discrepancy in different ethnicities.

Tumor Necrosis Factor-α Production-Enhancing Properties of Novel Adamantylalkylthio Derivatives of Some Heterocyclic Compounds

2005 ◽  
Vol 60 (4) ◽  
pp. 471-475 ◽  
Author(s):  
Barbara Orzeszko ◽  
Tomasz Świtaj ◽  
Anna B. Jakubowska-Mućka ◽  
Witold Lasek ◽  
Andrzej Orzeszko ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Heterocyclic Compounds ◽  
Tumor Necrosis ◽  
The Novel ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Factor Α ◽  
Derivatives Of ◽  
Necrosis Factor

Certain adamantylated heterocycles were previously shown to enhance the secretion of tumor necrosis factor alpha (TNF-α) by murine melanoma cells that have been transduced with the gene for human TNF-α and constitutively expressed this cytokine. The stimulatory potency of those compounds depended, among other factors, on the structure of the linker between the adamantyl residue and the heterocyclic core. In the present study, a series of (1-adamantyl)alkylsulfanyl derivatives of heterocyclic compounds was prepared by alkylation of the corresponding thioheterocyles. Of the novel adamantylalkylthio compounds tested in the aforementioned cell line, 2-(2-adamantan-1-ylethylsulfanyl)- 4-methyl-pyrimidine was found to be the most active

scholarly journals Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 Protein Inhibits Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Interacting with p65/RelA and p50/NF-κB1

2013 ◽  
Vol 87 (23) ◽  
pp. 12935-12948 ◽  
Author(s):  
Jie Zhang ◽  
Kezhen Wang ◽  
Shuai Wang ◽  
Chunfu Zheng
Keyword(s):  
Tumor Necrosis Factor ◽  
Ubiquitin Ligase ◽  
Tumor Necrosis ◽  
Nuclear Translocation ◽  
E3 Ubiquitin Ligase ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Hsv 1

NF-κB plays central roles in regulation of diverse biological processes, including innate and adaptive immunity and inflammation. HSV-1 is the archetypal member of the alphaherpesviruses, with a large genome encoding over 80 viral proteins, many of which are involved in virus-host interactions and show immune modulatory capabilities. In this study, we demonstrated that the HSV-1 ICP0 protein, a viral E3 ubiquitin ligase, was shown to significantly suppress tumor necrosis factor alpha (TNF-α)-mediated NF-κB activation. ICP0 was demonstrated to bind to the NF-κB subunits p65 and p50 by coimmunoprecipitation analysis. ICP0 bound to the Rel homology domain (RHD) of p65. Fluorescence microscopy demonstrated that ICP0 abolished nuclear translocation of p65 upon TNF-α stimulation. Also, ICP0 degraded p50 via its E3 ubiquitin ligase activity. The RING finger (RF) domain mutant ICP0 (ICP0-RF) lost its ability to inhibit TNF-α-mediated NF-κB activation and p65 nuclear translocation and degrade p50. Notably, the RF domain of ICP0 was sufficient to interact with p50 and abolish NF-κB reporter gene activity. Here, it is for the first time shown that HSV-1 ICP0 interacts with p65 and p50, degrades p50 through the ubiquitin-proteasome pathway, and prevents NF-κB-dependent gene expression, which may contribute to immune evasion and pathogenesis of HSV-1.

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